PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus C05C8.6 dre-1 14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 C27B7.4 14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 Y7A5A.2 14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 C05C8.6 12445390,14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 F52B11.1a 14704431 biogrid,mint,intact,dip exp G C05C8.6 gly-4 14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 F37B1.1 14704431 biogrid,i2d,mint,intact,dip exp G C05C8.6 Y116F11B.1 i2d exp G C05C8.6 tag-320 ortho G C05C8.6 ned-8 ortho G C05C8.6 csn-6 ortho G C05C8.6 csn-5 ortho G C05C8.6 F23C8.4 ortho G C05C8.6 R07E5.3 ortho G C05C8.6 cul-3 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O16313 - 14704431 - X 2 O16313 Q94251 - 14704431 - X 2 O16313 - 14704431 - X 2 Q18241 O16313 - 14704431 - X 2 Q9XVZ1 O16313 - 14704431 - X 2 O16313 Q93694 - 14704431 - X 2 O16313 O16313 - 14704431 - X 2 O16313 O16313 - 12445390 - X 2 Q8I136 O16313 - 14704431 - X 2 O16313 Q94251 two hybrid 14704431 direct interaction X 2 O16313 Q8I136-2 two hybrid 14704431 direct interaction X 2 Q18241 O16313 two hybrid 14704431 direct interaction X 2 Q9XVZ1 O16313 two hybrid 14704431 direct interaction X 2 O16313 O16313 two hybrid 12445390 direct interaction X 2 O16313 O16313 two hybrid 14704431 direct interaction X 2 O16313 Q93694 two hybrid 14704431 direct interaction X 2 O16313 D3YT77 two hybrid 14704431 direct interaction X 2 O16313 O16313 two hybrid 14704431 physical association Y 1 O16313 Q94251 two hybrid 14704431 physical association X 2 O16313 two hybrid 14704431 physical association X 2 O16313 Q8I136-2 two hybrid 14704431 physical association X 2 Q18241 O16313 two hybrid 14704431 physical association X 2 Q9XVZ1 O16313 two hybrid 14704431 physical association X 2 Q9XUE7 O16313 two hybrid 14704431 physical association X 2 O16313 Q93694 two hybrid 14704431 physical association X 2 O16313 Q94251 two hybrid pooling approach 14704431 physical association X 2 Q18241 O16313 two hybrid pooling approach 14704431 physical association X 2 Q9XVZ1 O16313 two hybrid pooling approach 14704431 physical association X 2 Q9XUE7 O16313 two hybrid pooling approach 14704431 physical association X 2 O16313 O16313 two hybrid 12445390 physical association X 2 O16313 O16313 two hybrid pooling approach 14704431 physical association X 2 O16313 Q93694 two hybrid pooling approach 14704431 physical association X 2 Q8I136 O16313 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B hpo-9 dre-1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip)|MI:0471(mint) BIOGRID_21442|UniProt_29608|DIP_1222|MINT_6758 bait|bait|-|bait prey|prey|-|prey hpo-9 gly-4 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0465(dip) BIOGRID_21443|MINT_6760|UniProt_29609|DIP_1224 bait|bait|bait|- prey|prey|prey|- hpo-9 CELE_Y7A5A.2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_1225|BIOGRID_21444|MINT_6761|UniProt_29610 -|bait|bait|bait -|prey|prey|prey hpo-9 F52B11.1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0465(dip)|MI:0471(mint) UniProt_29606|DIP_1221|MINT_6757 bait|-|bait prey|-|prey hpo-9 Q9NEJ8 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_29607|MINT_6759 bait|bait prey|prey hpo-9 cfp-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21441 bait prey hpo-9 gst-24 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_6756|UniProt_29605|BIOGRID_21440|DIP_1220 bait|bait|bait|- prey|prey|prey|- hpo-9 rad-26 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_6755|UniProt_29604|DIP_1219|BIOGRID_21439 bait|bait|-|bait prey|prey|-|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8I136 O16313 GLY-4 HPO-9 0.126 14704431 Q9NEJ8 O16313 Q9NEJ8 HPO-9 0.033 14704431 O61390 O16313 GLY-4 HPO-9 0.033 14704431 Q9XUE7 O16313 CFP-1 HPO-9 0.155 14704431 Q9XVZ1 O16313 Q9XVZ1 HPO-9 0.155 14704431 Q93694 O16313 GST-24 HPO-9 0.155 14704431 Q18241 O16313 RAD-26 HPO-9 0.155 14704431 O16313 O16313 HPO-9 HPO-9 0.376 12445390,14704431 Q94251 O16313 DRE-1 HPO-9 0.155 14704431