PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HAL5 DMA2 16319894 biogrid,i2d exp SSA2 DMA2 19536198 intact exp ERR1 DMA2 18467557 i2d,mint,intact exp THI4 DMA2 11283351 i2d,mint,intact,dip exp SSE1 DMA2 19536198 intact exp DMA2 DMA2 18202552,23442799 biogrid exp TAM41 DMA2 14690591 intact exp SSB2 DMA2 23332755 biogrid exp SSB1 DMA2 19536198 intact exp PHO84 DMA2 11805837 biogrid,intact,dip exp NOP9 DMA2 14690591 intact exp TEF1, TEF2 DMA2 11805837 dip exp CYR1 DMA2 i2d exp UBC5 DMA2 23442799 biogrid exp DMA2 Putative uncharacterized protein YDR433W 11283351 i2d,mint,intact,dip exp SAE2 DMA2 25762720 biogrid exp HEK2 DMA2 18805955 biogrid exp CRM1 DMA2 26673895 biogrid exp DMA2 GDE1 11805837 biogrid,intact,dip exp ERR2 DMA2 18467557 biogrid,i2d exp NAB2 DMA2 19840948 biogrid exp LAT1 DMA2 11805837 dip exp POG1 DMA2 25073408 biogrid exp IME2 DMA2 16319894 biogrid,i2d exp SSA1 DMA2 19536198 intact exp DMA2 SHS1 23442799 biogrid exp SKP2 DMA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred DMA2 CDC123 11283351,15319434,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred DMA2 MPS1 16319894, 23023127 biogrid,i2d exp, pred DMA2 SML1 11283351, 23023127 i2d,mint,intact,dip exp, pred SKP1 DMA2 19882662, 23023127 intact exp, pred UBC4 DMA2 18202552, 23023127 biogrid exp, pred UBC13 DMA2 18202552,23442799, 23023127 biogrid exp, pred CDC25 DMA2 19841731, 23023127 biogrid,mint,intact exp, pred STH1 DMA2 11805837, 23023127 biogrid,intact,dip exp, pred YCK2 DMA2 16319894, 23023127 biogrid,i2d exp, pred DMA2 CDC14 21127052, 23023127 biogrid exp, pred YCK1 DMA2 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred SLA1 DMA2 19841731, 23023127 biogrid,mint,intact exp, pred DMA1 DMA2 18202552,11805837, 23023127 biogrid,mint,intact,dip exp, pred RAD1 DMA2 11805837, 23023127 biogrid,intact,dip exp, pred NIP100 DMA2 23023127 pred DMA2 SGT1 23023127 pred CDC34 DMA2 23023127 pred PEX4 DMA2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53924 - 11805837 - C 10 P53924 - 11805837 - C 4 P53924 - 11805837 - C 17 Q04964 P53924 - 11283351 - X 2 P53924 P42843 - 11805837 - X 2 P53924 P38823 - 11805837 - X 2 P53924 P23291 - 10688190 - X 2 P53924 - 11283351 - X 2 P53924 P32318 - 11283351 - X 2 Q05791 P53924 - 11283351 - X 2 Q00684 P53924 affinity chromatography technology 21127052 physical association X 2 P23292 P53924 enzymatic study 16319894 direct interaction X 2 P15731 P53924 pull down 18202552 direct interaction X 2 P40473 P53924 two hybrid 25073408 direct interaction X 2 P06777 P53924 affinity chromatography technology 11805837 physical association X 2 Q07657 P53924 enzymatic study 23442799 direct interaction X 2 P53924 P32790 two hybrid 19841731 direct interaction X 2 P54199 P53924 enzymatic study 16319894 direct interaction X 2 P52490 P53924 two hybrid 23442799 direct interaction X 2 P52490 P53924 pull down 18202552 direct interaction X 2 P0CX10 P53924 protein complementation assay 18467557 direct interaction X 2 P40150 P53924 biochemical 23332755 association X 2 Q02979 P53924 affinity chromatography technology 11805837 physical association X 2 P0CG63 P53924 affinity chromatography technology 23749301 physical association X 2 P25297 P53924 affinity chromatography technology 11805837 physical association X 2 P53924 P15732 two hybrid 23442799 direct interaction X 2 P53924 P53924 enzymatic study 23442799 direct interaction X 2 P53924 P53924 enzymatic study 18202552 direct interaction X 2 P53924 P38823 enzymatic study 18202552 direct interaction X 2 P53924 P38823 enzymatic study 18202552 direct interaction X 2 P53924 P62837 pull down 23442799 direct interaction X 2 P53924 P32581 enzymatic study 16319894 direct interaction X 2 P53924 P04821 two hybrid 19841731 direct interaction X 2 P53924 P32597 affinity chromatography technology 11805837 physical association X 2 P53924 P42843 affinity chromatography technology 11805837 physical association X 2 P53924 P42843 affinity chromatography technology 11805837 physical association X 2 P53924 P38823 affinity chromatography technology 11805837 physical association X 2 P53924 P23291 two hybrid 10688190 direct interaction X 2 P38970 P53924 enzymatic study 16319894 direct interaction X 2 Q05791 P53924 affinity chromatography technology 15319434 physical association X 2 Q05791 P53924 two hybrid 18719252 direct interaction X 2 P53924 anti tag coimmunoprecipitation 11805837 - C 28 P53924 anti tag coimmunoprecipitation 11805837 - C 5 P53924 anti tag coimmunoprecipitation 11805837 - C 26 P06777 P53924 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02979 P53924 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 anti tag coimmunoprecipitation 11805837 - C 3 P53924 anti tag coimmunoprecipitation 11805837 - C 7 P53924 anti tag coimmunoprecipitation 11805837 - C 19 P53924 anti tag coimmunoprecipitation 11805837 - C 10 P12695 P53924 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04964 P53924 two hybrid pooling approach 11283351 physical association X 2 P25297 P53924 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P32318 two hybrid pooling approach 11283351 physical association X 2 P53924 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P87269 two hybrid pooling approach 11283351 physical association X 2 P53924 P38823 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P32597 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P23291 two hybrid 10688190 physical association X 2 Q05791 P53924 two hybrid pooling approach 11283351 physical association X 2 P53924 anti tag coimmunoprecipitation 11805837 association C 17 P53924 P53230 two hybrid array 14690591 physical association X 2 P53924 P32790 two hybrid pooling approach 19841731 physical association X 2 P0CX10 P53924 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53924 pull down 14690591 association C 36 P53924 pull down 19882662 association C 51 P53924 anti tag coimmunoprecipitation 11805837 association C 4 P53924 anti tag coimmunoprecipitation 11805837 association C 10 P10592 P53924 tandem affinity purification 19536198 association X 2 P32589 P53924 tandem affinity purification 19536198 association X 2 P11484 P53924 tandem affinity purification 19536198 association X 2 Q04964 P53924 two hybrid fragment pooling approach 11283351 physical association X 2 P53924 P23291 two hybrid 10688190 physical association X 2 P53924 P87269 two hybrid fragment pooling approach 11283351 physical association X 2 P53924 P32318 two hybrid fragment pooling approach 11283351 physical association X 2 P53924 P38823 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P04821 two hybrid pooling approach 19841731 physical association X 2 P10591 P53924 tandem affinity purification 19536198 association X 2 Q05791 P53924 two hybrid fragment pooling approach 11283351 physical association X 2 Q05791 P53924 two hybrid 18719252 physical association X 2 P53924 mass spectrometry studies of complexes 11805837 - C 4 P53924 mass spectrometry studies of complexes 11805837 - C 6 P53924 mass spectrometry studies of complexes 11805837 - C 6 P53924 mass spectrometry studies of complexes 11805837 - C 11 P53924 mass spectrometry studies of complexes 11805837 - C 20 Q04964 P53924 two hybrid 11283351 - X 2 P53924 P23291 two hybrid 10688190 - X 2 P53924 P32318 two hybrid 11283351 - X 2 P53924 P87269 two hybrid 11283351 - X 2 Q05791 P53924 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC25 DMA2 19841731,19841731 0398,0018 HT ERR1 DMA2 18467557,18467557 0111,0090 HT ERR2 DMA2 18467557 0090 HT UBC4 DMA2 18202552,18202552 0096,0415 LC UBC5 DMA2 23442799 0018 LC YCK1 DMA2 10688190,10688190 0397,0018 HT YCK2 DMA2 16319894 0415 LC THI4 DMA2 11283351,11283351,11283351 0018,0399,0398 HT IME2 DMA2 16319894 0415 LC SLA1 DMA2 19841731,19841731 0398,0018 HT DMA1 DMA2 18202552 0415 LC HAL5 DMA2 16319894 0415 LC SSB2 DMA2 23332755 0401 LC POG1 DMA2 25073408 0018 LC UBC13 DMA2 18202552,18202552,23442799 0096,0415,0018 LC TAM41 DMA2 14690591 0397 LC DMA2 DMA2 23442799,18202552 0415,0415 LC DMA2 MPS1 16319894 0415 LC DMA2 P87269 11283351,11283351,11283351 0018,0399,0398 HT DMA2 SML1 11283351,11283351,11283351 0018,0399,0398 HT DMA2 CDC123 11283351,18719252,11283351,11283351 0018,0018,0399,0398 HT DMA2 SHS1 23442799 0415 LC TEF1|TEF2 DMA2 11805837 0007 HT RAD1 DMA2 11805837,11805837 0004,0007 HT SSA1 DMA2 19536198 0676 HT SSA2 DMA2 19536198 0676 HT SSB1 DMA2 19536198 0676 HT LAT1 DMA2 11805837 0007 HT UBC4 DMA2 18202552,18202552 0096,0415 LC PHO84 DMA2 11805837,11805837 0004,0007 HT CRM1 DMA2 26673895,26673895 0096,0004 LC NAB2 DMA2 19840948 0004 LC SSE1 DMA2 19536198 0676 HT STH1 DMA2 11805837,11805837 0004,0007 HT DMA1 DMA2 11805837,11805837 0004,0007 HT SSB2 DMA2 23332755 0401 LC SKP2 DMA2 11805837,11805837 0004,0007 HT SAE2 DMA2 25762720 0004 LC SKP1 DMA2 19882662 0096 LC UBC13 DMA2 18202552,18202552 0096,0415 LC DMA2 CDC14 21127052 0004 LC DMA2 GDE1 11805837,11805837 0004,0007 HT DMA2 CDC123 15319434 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53924 P23292 DMA2 YCK2 0.183 16319894 Q04964 P53924 SML1 DMA2 0.21 11283351 P53924 P0CX10 DMA2 ERR1 0.126 18467557 P53924 P10591 DMA2 SSA1 0.126 19536198 P53924 P30822 DMA2 CRM1 0.126 26673895 P53924 P38199 DMA2 HEK2 0.126 18805955 P53924 P32318 DMA2 THI4 0.21 11283351 P53924 P32505 DMA2 NAB2 0.126 19840948 P53924 P38823 DMA2 DMA1 0.236 11805837 P53924 P32581 DMA2 IME2 0.183 16319894 P53924 P32589 DMA2 SSE1 0.126 19536198 P53924 P38970 DMA2 HAL5 0.183 16319894 P53924 P40150 DMA2 SSB2 0.126 23332755 P53924 P40473 DMA2 POG1 0.309 25073408 P53924 P46946 DMA2 SAE2 0.454 25762720 P53924 P47077 DMA2 NOP9 0.126 14690591 Q00684 P53924 CDC14 DMA2 0.126 21127052 P53924 P52286 DMA2 SKP1 0.236 19882662 Q02979 P53924 GDE1 DMA2 0.236 11805837 P53924 P02994 DMA2 TEF2 0.126 11805837 P53924 P04821 DMA2 CDC25 0.354 19841731 P53924 P06777 DMA2 RAD1 0.236 11805837 P53924 P10592 DMA2 SSA2 0.126 19536198 P53924 P11484 DMA2 SSB1 0.126 19536198 P53924 P12695 DMA2 LAT1 0.126 11805837 P53924 P15732 DMA2 UBC5 0.309 23442799 P53924 P23291 DMA2 YCK1 0.332 10688190 P53924 P25297 DMA2 PHO84 0.236 11805837 P53924 P32597 DMA2 STH1 0.21 11805837 P53924 P32790 DMA2 SLA1 0.376 19841731 P53924 P42843 DMA2 SKP2 0.332 11805837 P53924 P52490 DMA2 UBC13 0.309 23442799 P53924 P53230 DMA2 TAM41 0.126 14690591 P53924 P53924 DMA2 DMA2 0.332 23442799 P62837 P53924 UBE2D2 DMA2 0.309 23442799 P87269 P53924 P87269 DMA2 0.21 11283351 Q05791 P53924 CDC123 DMA2 0.583 11283351,15319434,18719252 Q07657 P53924 SHS1 DMA2 0.309 23442799 P54199 P53924 MPS1 DMA2 0.183 16319894