iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032507.15	ENSMUST00000117537.7	ENSMUSP00000114075.1
ENSMUSG00000032507.15	ENSMUST00000143180.7	ENSMUSP00000117058.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.98	0.00e+00	828.00	IUUC-Hsa-046452

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (PubMed:21343341).

Protein Sequence
(Fasta)

MVFSNSDDGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRVDLFNF 60
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATGCCGGA AGGAGCTCCA CTACACAGCC ATAGAAGAGC CATCTGCTGA GTGCAACCCT 60
CCATTGCGGC CCTGTTAAGG CCACCTATGC TCCCGCCTGT GACCCTCACC CCTAGCTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0016020--C:membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0036312--F:phosphatidylinositol 3-kinase regulatory subunit binding
GO:0019903--F:protein phosphatase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination
GO:0010506--P:regulation of autophagy
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:72179

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000558	Aegilops tauschii	28.66	3.00e-24	106.00
IUUC-Aml-001591	Ailuropoda melanoleuca	95.02	0.00e+00	818.00
IUUC-Atr-002443	Amborella trichopoda	30.33	8.00e-37	147.00
IUUC-Apl-004140	Anas platyrhynchos	88.68	0.00e+00	753.00
IUUC-Aly-006082	Arabidopsis lyrata	30.03	3.00e-32	132.00
IUUC-Ath-007544	Arabidopsis thaliana	28.45	5.00e-37	149.00
IUUC-Ago-007921	Ashbya gossypii	27.93	2.00e-23	105.00
IUUC-Acl-008241	Aspergillus clavatus	30.14	3.00e-41	163.00
IUUC-Afl-008737	Aspergillus flavus	29.48	4.00e-40	159.00
IUUC-Ani-009150	Aspergillus nidulans	26.93	9.00e-34	138.00
IUUC-Ang-009576	Aspergillus niger	31.03	3.00e-42	166.00
IUUC-Aor-010026	Aspergillus oryzae	29.48	4.00e-40	159.00
IUUC-Ate-010557	Aspergillus terreus	29.36	4.00e-42	166.00
IUUC-Ame-011331	Astyanax mexicanus	80.09	0.00e+00	720.00
IUUC-Bgr-012170	Blumeria graminis	30.53	5.00e-37	149.00
IUUC-Bta-013330	Bos taurus	92.20	0.00e+00	711.00
IUUC-Bol-016123	Brassica oleracea	31.38	4.00e-39	155.00
IUUC-Bra-017999	Brassica rapa	30.46	1.00e-38	153.00
IUUC-Cja-019372	Callithrix jacchus	91.85	0.00e+00	755.00
IUUC-Cfa-020668	Canis familiaris	95.02	0.00e+00	819.00
IUUC-Cpo-022092	Cavia porcellus	92.18	0.00e+00	790.00
IUUC-Cre-022929	Chlamydomonas reinhardtii	26.85	3.00e-07	49.70
IUUC-Csa-023598	Chlorocebus sabaeus	96.22	0.00e+00	829.00
IUUC-Cho-024787	Choloepus hoffmanni	89.57	0.00e+00	754.00
IUUC-Cgl-026536	Colletotrichum gloeosporioides	30.40	4.00e-40	159.00
IUUC-Dre-028795	Danio rerio	79.62	0.00e+00	718.00
IUUC-Dno-030049	Dasypus novemcinctus	90.05	0.00e+00	779.00
IUUC-Dor-030749	Dipodomys ordii	71.19	7.00e-113	400.00
IUUC-Dse-031311	Dothistroma septosporum	28.16	1.00e-35	144.00
IUUC-Ete-033027	Echinops telfairi	84.29	0.00e+00	667.00
IUUC-Eca-033723	Equus caballus	95.26	0.00e+00	820.00
IUUC-Eeu-034930	Erinaceus europaeus	80.57	0.00e+00	677.00
IUUC-Fca-035670	Felis catus	94.79	0.00e+00	817.00
IUUC-Fal-037377	Ficedula albicollis	89.57	0.00e+00	760.00
IUUC-Fox-037979	Fusarium oxysporum	28.75	4.00e-40	159.00
IUUC-Fso-038098	Fusarium solani	29.12	5.00e-41	162.00
IUUC-Gmo-038722	Gadus morhua	79.38	0.00e+00	714.00
IUUC-Gga-040836	Gallus gallus	88.15	0.00e+00	746.00
IUUC-Gac-041367	Gasterosteus aculeatus	79.15	0.00e+00	713.00
IUUC-Ggo-044534	Gorilla gorilla	95.98	0.00e+00	828.00
IUUC-Hsa-046452	Homo sapiens	95.98	0.00e+00	828.00
IUUC-Hvu-047491	Hordeum vulgare	31.19	8.00e-32	131.00
IUUC-Kpa-049356	Komagataella pastoris	29.88	3.00e-32	133.00
IUUC-Laf-053965	Loxodonta africana	93.32	0.00e+00	772.00
IUUC-Mcc-055012	Macaca mulatta	96.22	0.00e+00	829.00
IUUC-Mor-057009	Magnaporthe oryzae	29.10	6.00e-33	135.00
IUUC-Mtr-057762	Medicago truncatula	30.65	1.00e-37	150.00
IUUC-Mga-059494	Meleagris gallopavo	87.74	0.00e+00	739.00
IUUC-Mmr-061409	Microcebus murinus	95.74	0.00e+00	827.00
IUUC-Mac-064776	Musa acuminata	31.15	2.00e-35	143.00
IUUC-Mpu-065900	Mustela putorius furo	95.04	0.00e+00	823.00
IUUC-Mlu-067809	Myotis lucifugus	94.08	0.00e+00	809.00
IUUC-Nfi-068415	Neosartorya fischeri	28.26	3.00e-39	157.00
IUUC-Ncr-068681	Neurospora crassa	29.97	2.00e-30	127.00
IUUC-Nle-069953	Nomascus leucogenys	95.98	0.00e+00	828.00
IUUC-Opr-070495	Ochotona princeps	82.70	0.00e+00	698.00
IUUC-Oan-072994	Ornithorhynchus anatinus	88.86	0.00e+00	752.00
IUUC-Oba-075119	Oryza barthii	29.95	5.00e-37	149.00
IUUC-Ogl-077393	Oryza glaberrima	29.95	4.00e-37	149.00
IUUC-Osa-085630	Oryza sativa	29.06	6.00e-32	132.00
IUUC-Oga-088914	Otolemur garnettii	95.76	0.00e+00	783.00
IUUC-Oar-089424	Ovis aries	88.42	0.00e+00	679.00
IUUC-Ptr-090892	Pan troglodytes	95.98	0.00e+00	828.00
IUUC-Pan-092497	Papio anubis	96.22	0.00e+00	829.00
IUUC-Pno-095080	Phaeosphaeria nodorum	28.88	8.00e-39	155.00
IUUC-Ppa-095706	Physcomitrella patens	31.77	4.00e-36	146.00
IUUC-Pab-097772	Pongo abelii	95.98	0.00e+00	828.00
IUUC-Pop-100090	Populus trichocarpa	30.03	2.00e-31	130.00
IUUC-Pca-100518	Procavia capensis	78.44	0.00e+00	632.00
IUUC-Pva-102623	Pteropus vampyrus	94.33	0.00e+00	816.00
IUUC-Pte-104289	Pyrenophora teres	28.16	2.00e-40	160.00
IUUC-Pyt-104761	Pyrenophora triticirepentis	28.16	7.00e-40	159.00
IUUC-Rno-105398	Rattus norvegicus	98.82	0.00e+00	842.00
IUUC-Smo-109364	Selaginella moellendorffii	30.74	2.00e-36	147.00
IUUC-Sit-110068	Setaria italica	31.04	9.00e-33	135.00
IUUC-Sly-110948	Solanum lycopersicum	28.01	6.00e-33	135.00
IUUC-Tgu-117483	Taeniopygia guttata	88.86	0.00e+00	756.00
IUUC-Tsy-119215	Tarsius syrichta	86.49	0.00e+00	729.00
IUUC-Tre-122101	Trichoderma reesei	29.67	5.00e-38	152.00
IUUC-Tvi-122616	Trichoderma virens	30.22	7.00e-41	162.00
IUUC-Tur-126305	Triticum urartu	31.50	4.00e-33	135.00
IUUC-Tme-127127	Tuber melanosporum	29.85	5.00e-41	162.00
IUUC-Tbe-128062	Tupaia belangeri	91.21	0.00e+00	777.00
IUUC-Ttr-129221	Tursiops truncatus	86.26	0.00e+00	696.00
IUUC-Vda-129798	Verticillium dahliae	29.65	2.00e-37	150.00
IUUC-Vpa-130791	Vicugna pacos	86.26	0.00e+00	723.00
IUUC-Yli-134644	Yarrowia lipolytica	27.37	1.00e-29	125.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence