iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046872

UUCD1 version

UUC-HoS-00451

Ensembl Protein ID

ENSP00000219548.4

UniProt Accession

Q9UNE7; A2IDB9; O60526; Q969U2; Q9HBT1; CHIP_HUMAN

Genbank Protein ID

AAC18038.1; AAD33400.1; AAL99927.1; AAG17211.1; AAK61242.1; CAM26348.1; EAW85758.1; AAH07545.1; AAH17178.1; AAH22788.1; AAH63617.1

Protein Name

E3 ubiquitin-protein ligase CHIP; Antigen NY-CO-7; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1

Genbank Nucleotide ID

AF039689; AF129085; AF432221; AF217968; AE006464; Z92544; CH471112; BC007545; BC017178; BC022788; BC063617

Gene Name

STUB1; CHIP; PP1131

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103266.10	ENST00000219548.8	ENSP00000219548.4
ENSG00000103266.10	ENST00000567173.5	ENSP00000456591.1
ENSG00000103266.10	ENST00000566408.5	ENSP00000457583.1
ENSG00000103266.10	ENST00000564316.1	ENSP00000457090.1
ENSG00000103266.10	ENST00000565813.1	ENSP00000476751.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	17525155; 17873020; 18381433; 18655187; 18313385; 19103148; 19741096; 18922468; 18955503; 19706771; 15466472; 19642705; 19536328; 19020010; 19483080; 19153604; 19465479; 19406989; 15538384; 17178836; 16740632; 16280320; 14612456; 15761032; 21358815; 19940151; 21124777; 20924358; 19940115; 19913553; 20588253; 17963781; 20724525; 20075607; 17324930; 16940184; 16207813; 11557750; 12297498; 15781469; 25225294; 24106274; 20943656

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.80e-26	93.0	226	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p+++++ Is+elMr+P+++psGitydr+ Ie++l++ g+ +Pvtr+plt+e+l+Pnl+++++i+a+++en++
   Q: 226  DIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGW 299
           69********************************************************************9986 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385).

Protein Sequence
(Fasta)

MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA 60
VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCCAGGG CCTACGCGAA CGCCCACCCT TAAGAGCGCG GGGACAGGGA ACTGGAGCGT 60
TCCTCCCAGC CCCCGACGTC GCGGGCCCAG TGTCCCCGTC CAGGCTGGTT GGGCGCACGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0031371--C:ubiquitin conjugating enzyme complex
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0019899--F:enzyme binding
GO:0001664--F:G-protein coupled receptor binding
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0019900--F:kinase binding
GO:0051787--F:misfolded protein binding
GO:0030674--F:protein binding, bridging
GO:0042803--F:protein homodimerization activity
GO:0046332--F:SMAD binding
GO:0030911--F:TPR domain binding
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071218--P:cellular response to misfolded protein
GO:0006281--P:DNA repair
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0038128--P:ERBB2 signaling pathway
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0032091--P:negative regulation of protein binding
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0051604--P:protein maturation
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

hsa:10273

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	35.50	2.00e-38	152.00
IUUC-Aml-001350	Ailuropoda melanoleuca	97.20	8.00e-141	492.00
IUUC-Atr-003168	Amborella trichopoda	34.91	1.00e-29	123.00
IUUC-Apl-003736	Anas platyrhynchos	87.65	2.00e-127	447.00
IUUC-Aca-004751	Anolis carolinensis	85.21	1.00e-137	482.00
IUUC-Aly-006292	Arabidopsis lyrata	34.41	2.00e-44	172.00
IUUC-Ath-007012	Arabidopsis thaliana	33.69	3.00e-41	161.00
IUUC-Acl-008025	Aspergillus clavatus	32.52	2.00e-33	135.00
IUUC-Afl-008721	Aspergillus flavus	31.47	1.00e-30	127.00
IUUC-Afu-008853	Aspergillus fumigatus	32.52	6.00e-33	134.00
IUUC-Ani-009349	Aspergillus nidulans	31.27	3.00e-32	132.00
IUUC-Ang-009674	Aspergillus niger	33.33	8.00e-30	124.00
IUUC-Aor-010014	Aspergillus oryzae	29.81	3.00e-25	108.00
IUUC-Ate-010467	Aspergillus terreus	30.64	7.00e-27	114.00
IUUC-Ame-011215	Astyanax mexicanus	59.79	4.00e-87	314.00
IUUC-Bgr-011971	Blumeria graminis	29.39	9.00e-25	107.00
IUUC-Bta-013025	Bos taurus	97.34	4.00e-164	570.00
IUUC-Bci-013945	Botrytis cinerea	39.51	6.00e-15	74.70
IUUC-Bdi-014483	Brachypodium distachyon	38.04	1.00e-44	173.00
IUUC-Bol-015676	Brassica oleracea	35.34	2.00e-45	176.00
IUUC-Bra-017897	Brassica rapa	32.54	1.00e-28	119.00
IUUC-Cel-018323	Caenorhabditis elegans	40.79	2.00e-54	206.00
IUUC-Cja-019657	Callithrix jacchus	98.95	9.00e-170	588.00
IUUC-Cfa-020470	Canis familiaris	97.40	1.00e-128	452.00
IUUC-Cpo-022033	Cavia porcellus	97.36	8.00e-166	575.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	27.59	9.00e-28	117.00
IUUC-Csa-023038	Chlorocebus sabaeus	100.00	2.00e-162	564.00
IUUC-Cin-025381	Ciona intestinalis	52.67	3.00e-85	308.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.26	5.00e-38	151.00
IUUC-Dre-027610	Danio rerio	77.24	2.00e-132	464.00
IUUC-Dno-030087	Dasypus novemcinctus	95.71	2.00e-163	568.00
IUUC-Dor-031029	Dipodomys ordii	92.63	1.00e-151	529.00
IUUC-Dse-031275	Dothistroma septosporum	31.85	1.00e-25	110.00
IUUC-Dme-031856	Drosophila melanogaster	57.71	3.00e-93	334.00
IUUC-Ete-033087	Echinops telfairi	92.65	9.00e-134	469.00
IUUC-Eca-033512	Equus caballus	97.60	4.00e-141	493.00
IUUC-Eeu-034763	Erinaceus europaeus	90.76	5.00e-92	329.00
IUUC-Fca-036460	Felis catus	97.79	3.00e-155	540.00
IUUC-Fal-037441	Ficedula albicollis	87.76	3.00e-145	507.00
IUUC-Fox-038028	Fusarium oxysporum	30.72	3.00e-36	145.00
IUUC-Fso-038323	Fusarium solani	31.91	8.00e-28	117.00
IUUC-Gmo-038511	Gadus morhua	77.19	7.00e-127	446.00
IUUC-Ggr-039964	Gaeumannomyces graminis	33.68	5.00e-25	108.00
IUUC-Gga-040854	Gallus gallus	88.11	8.00e-145	506.00
IUUC-Gac-042175	Gasterosteus aculeatus	73.79	8.00e-123	432.00
IUUC-Gma-044046	Glycine max	35.14	3.00e-42	165.00
IUUC-Ggo-044512	Gorilla gorilla	100.00	2.00e-162	564.00
IUUC-Hvu-047661	Hordeum vulgare	34.40	5.00e-39	154.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	98.60	2.00e-168	584.00
IUUC-Lch-049988	Latimeria chalumnae	79.37	1.00e-132	465.00
IUUC-Lpe-050693	Leersia perrieri	34.42	2.00e-42	166.00
IUUC-Loc-052195	Lepisosteus oculatus	78.04	4.00e-113	400.00
IUUC-Lma-053207	Leptosphaeria maculans	30.62	7.00e-28	119.00
IUUC-Laf-054584	Loxodonta africana	95.38	2.00e-163	568.00
IUUC-Mcc-054689	Macaca mulatta	100.00	2.00e-162	564.00
IUUC-Meu-055998	Macropus eugenii	88.95	1.00e-81	296.00
IUUC-Mor-057116	Magnaporthe oryzae	34.39	5.00e-40	158.00
IUUC-Mtr-057684	Medicago truncatula	32.14	5.00e-38	151.00
IUUC-Mga-059332	Meleagris gallopavo	88.05	4.00e-127	447.00
IUUC-Mmr-061377	Microcebus murinus	98.60	3.00e-160	557.00
IUUC-Mdo-061963	Monodelphis domestica	91.26	1.00e-146	512.00
IUUC-Mmu-063146	Mus musculus	97.37	6.00e-161	559.00
IUUC-Mac-064932	Musa acuminata	34.63	1.00e-27	116.00
IUUC-Mpu-066418	Mustela putorius furo	97.54	2.00e-162	564.00
IUUC-Mlu-067066	Myotis lucifugus	97.36	1.00e-165	575.00
IUUC-Nfi-068601	Neosartorya fischeri	32.52	1.00e-32	133.00
IUUC-Ncr-068761	Neurospora crassa	41.67	3.00e-17	82.00
IUUC-Nle-069374	Nomascus leucogenys	100.00	2.00e-162	564.00
IUUC-Opr-070765	Ochotona princeps	93.44	1.00e-97	348.00
IUUC-Ont-071996	Oreochromis niloticus	79.65	2.00e-130	458.00
IUUC-Oba-075967	Oryza barthii	35.74	1.00e-43	169.00
IUUC-Obr-076440	Oryza brachyantha	33.91	1.00e-29	126.00
IUUC-Ogl-077495	Oryza glaberrima	35.74	1.00e-43	169.00
IUUC-Ogu-078247	Oryza glumaepatula	35.57	3.00e-39	155.00
IUUC-Oin-079376	Oryza indica	35.74	1.00e-43	169.00
IUUC-Olo-081083	Oryza longistaminata	31.52	3.00e-30	125.00
IUUC-Ome-081935	Oryza meridionalis	28.30	5.00e-20	94.40
IUUC-Oni-082535	Oryza nivara	35.57	3.00e-39	155.00
IUUC-Opu-083794	Oryza punctata	35.74	5.00e-43	167.00
IUUC-Oru-085153	Oryza rufipogon	35.74	3.00e-43	168.00
IUUC-Osa-085936	Oryza sativa	35.82	1.00e-16	79.30
IUUC-Ola-087081	Oryzias latipes	77.89	1.00e-129	455.00
IUUC-Olu-087790	Ostreococcus lucimarinus	31.90	2.00e-31	129.00
IUUC-Oga-088331	Otolemur garnettii	98.35	1.00e-164	572.00
IUUC-Oar-089987	Ovis aries	92.97	8.00e-137	479.00
IUUC-Ptr-090855	Pan troglodytes	100.00	2.00e-162	564.00
IUUC-Pan-092801	Papio anubis	94.39	5.00e-157	546.00
IUUC-Psi-093393	Pelodiscus sinensis	86.85	5.00e-126	443.00
IUUC-Pma-094680	Petromyzon marinus	68.93	5.00e-110	390.00
IUUC-Pno-094913	Phaeosphaeria nodorum	31.88	1.00e-32	133.00
IUUC-Ppa-095508	Physcomitrella patens	32.50	1.00e-41	163.00
IUUC-Pfo-096850	Poecilia formosa	77.54	5.00e-127	447.00
IUUC-Pab-097963	Pongo abelii	100.00	2.00e-162	564.00
IUUC-Pop-098805	Populus trichocarpa	42.86	1.00e-24	106.00
IUUC-Pca-100788	Procavia capensis	96.37	3.00e-165	573.00
IUUC-Ppe-101221	Prunus persica	33.45	3.00e-43	168.00
IUUC-Pva-103076	Pteropus vampyrus	96.04	8.00e-165	572.00
IUUC-Pte-104237	Pyrenophora teres	31.82	9.00e-33	134.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	31.82	7.00e-33	134.00
IUUC-Rno-105204	Rattus norvegicus	97.37	3.00e-161	560.00
IUUC-Sha-106579	Sarcophilus harrisii	86.33	2.00e-126	444.00
IUUC-Smo-109525	Selaginella moellendorffii	35.77	3.00e-41	162.00
IUUC-Sit-110665	Setaria italica	35.36	2.00e-42	166.00
IUUC-Sly-111473	Solanum lycopersicum	35.59	9.00e-44	170.00
IUUC-Stu-112353	Solanum tuberosum	34.98	3.00e-42	165.00
IUUC-Sbi-114250	Sorghum bicolor	36.59	2.00e-44	172.00
IUUC-Ssc-115416	Sus scrofa	96.70	9.00e-165	572.00
IUUC-Tgu-117272	Taeniopygia guttata	93.52	6.00e-57	211.00
IUUC-Tru-117777	Takifugu rubripes	78.60	8.00e-129	452.00
IUUC-Tni-120572	Tetraodon nigroviridis	80.00	6.00e-130	456.00
IUUC-Tca-121149	Theobroma cacao	37.55	1.00e-47	182.00
IUUC-Tre-122230	Trichoderma reesei	33.21	2.00e-32	132.00
IUUC-Tvi-122678	Trichoderma virens	35.61	7.00e-41	160.00
IUUC-Tae-122986	Triticum aestivum	34.40	6.00e-42	164.00
IUUC-Tur-126009	Triticum urartu	34.23	1.00e-37	149.00
IUUC-Tme-126948	Tuber melanosporum	35.48	4.00e-41	161.00
IUUC-Ttr-129031	Tursiops truncatus	94.39	9.00e-163	565.00
IUUC-Vda-130023	Verticillium dahliae	32.97	2.00e-37	149.00
IUUC-Vvi-131091	Vitis vinifera	49.44	1.00e-25	108.00
IUUC-Xtr-132871	Xenopus tropicalis	82.86	5.00e-129	453.00
IUUC-Xma-134220	Xiphophorus maculatus	77.89	2.00e-127	448.00
IUUC-Yli-134462	Yarrowia lipolytica	27.92	2.00e-28	119.00
IUUC-Zma-135773	Zea mays	35.61	6.00e-44	171.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence