iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007248

Ensembl Protein ID

AT1G64280.1

UniProt Accession

P93002; O04742; NPR1_ARATH

Genbank Protein ID

AAC49611.1; AAB58262.1; AAG51705.1; AEE34220.1; AAK91469.1; AAM16253.1

Protein Name

Regulatory protein NPR1; BTB/POZ domain-containing protein NPR1; Non-inducible immunity protein 1; Nonexpresser of PR genes 1; Salicylic acid insensitive 1

Genbank Nucleotide ID

U76707; U87794; AC066689; CP002684; AY050455; AY093992

Gene Name

NPR1; NIM1; SAI1; At1g64280; F15H21.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G64280	AT1G64280.1	AT1G64280.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.40e-06	28.2	65	141

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveik....d......vqpevfrallkFlYtgkld 66
           +D  lv+  g+e++ h++vL+a+Ss+F++ +    +e++s+++  +k    +      v  +++ ++l ++Y+++++
   Q: 65   SDAKLVLSdGREVSFHRCVLSARSSFFKSALAAAKKEKDSNNTAAVKlelkEiakdyeVGFDSVVTVLAYVYSSRVR 141
           588999999**********************7777766555555554425425555888899999999999999886 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.

Protein Sequence
(Fasta)

MDTTIDGFAD SYEISSTSFV ATDNTDSSIV YLAAEQVLTG PDVSALQLLS NSFESVFDSP 60
DDFYSDAKLV LSDGREVSFH RCVLSARSSF FKSALAAAKK EKDSNNTAAV KLELKEIAKD 120

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Nucleotide Sequence
(Fasta)

CTTCCTGTTA TATCTTTTTA AAAAAGATCT CTGACAAAGA TTCCTTTCCT GGAAATTTAC 60
CGGTTTTGGT GAAATGTAAA CCGTGGGACG AGGATGCTTC TTCATATCTC ACCACCACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0381--Hypersensitive response
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0611--Plant defense
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0702--S-nitrosylation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR021094--NPR1/NIM1-like_C
IPR024228--NPR_central_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF12796--Ank_2
PF00651--BTB
PF11900--DUF3420
PF12313--NPR1_like_C

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0050832--P:defense response to fungus
GO:0009682--P:induced systemic resistance
GO:0031348--P:negative regulation of defense response
GO:0009626--P:plant-type hypersensitive response
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0016567--P:protein ubiquitination
GO:2000022--P:regulation of jasmonic acid mediated signaling pathway
GO:2000031--P:regulation of salicylic acid mediated signaling pathway
GO:0010112--P:regulation of systemic acquired resistance
GO:0009617--P:response to bacterium
GO:0009408--P:response to heat
GO:0001666--P:response to hypoxia
GO:0009625--P:response to insect
GO:0009611--P:response to wounding
GO:0009627--P:systemic acquired resistance
GO:0009862--P:systemic acquired resistance, salicylic acid mediated signaling pathway

KEGG

ath:AT1G64280

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002638	Amborella trichopoda	50.00	2.00e-146	512.00
IUUC-Aly-006379	Arabidopsis lyrata	89.68	0.00e+00	992.00
IUUC-Afl-008572	Aspergillus flavus	26.74	2.90e-01	25.80
IUUC-Ani-009163	Aspergillus nidulans	33.78	4.00e-04	38.90
IUUC-Bdi-014610	Brachypodium distachyon	49.62	2.00e-135	475.00
IUUC-Bol-016261	Brassica oleracea	73.86	0.00e+00	765.00
IUUC-Bra-017644	Brassica rapa	73.92	0.00e+00	778.00
IUUC-Dse-031400	Dothistroma septosporum	27.20	3.00e-04	37.40
IUUC-Gma-042806	Glycine max	49.81	3.00e-143	501.00
IUUC-Mtr-057702	Medicago truncatula	52.55	3.00e-155	541.00
IUUC-Mac-065648	Musa acuminata	50.19	2.00e-147	515.00
IUUC-Opu-083512	Oryza punctata	47.66	5.00e-132	464.00
IUUC-Pop-098879	Populus trichocarpa	54.31	8.00e-172	596.00
IUUC-Ppe-102019	Prunus persica	53.48	1.00e-161	562.00
IUUC-Sit-110617	Setaria italica	46.80	2.00e-120	426.00
IUUC-Sly-111592	Solanum lycopersicum	53.21	3.00e-155	541.00
IUUC-Sbi-113938	Sorghum bicolor	48.40	5.00e-132	464.00
IUUC-Tca-121782	Theobroma cacao	56.16	0.00e+00	632.00
IUUC-Vvi-131096	Vitis vinifera	55.66	3.00e-168	584.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence