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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046208
Ensembl Protein ID ENSP00000360916.3
UniProt Accession P52735; A2RUM4; A8MQ12; B6ZDF5; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317; VAV2_HUMAN
Genbank Protein ID AAB34377.1; CAI12279.1; CAI12279.1; CAI12279.1; CAI13722.1; CAI13722.1; CAI13722.1; CAI15783.1; CAI15783.1; CAI15783.1; CAI12278.1; CAI12278.1; CAI12278.1; CAI13723.1; CAI13723.1; CAI13723.1; CAI15781.1; CAI15781.1; CAI15781.1; CAI12280.1; CAI12280.1; CAI12280.1; CAI13724.1; CAI13724.1; CAI13724.1; CAI15782.1; CAI15782.1; CAI15782.1; EAW88108.1; AAH33187.1; AAI32966.1; AAI32968.1; CAE45861.1; AAS75591.1
Protein Name Guanine nucleotide exchange factor VAV2
Genbank Nucleotide ID S76992; AL590710; AL357934; AL445931; AL445931; AL357934; AL590710; AL357934; AL445931; AL590710; AL590710; AL357934; AL445931; AL445931; AL357934; AL590710; AL357934; AL445931; AL590710; AL590710; AL357934; AL445931; AL445931; AL357934; AL590710; AL357934; AL445931; AL590710; CH471090; BC033187; BC132965; BC132967; BX640754; AY563001
Gene Name VAV2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160293.16 ENST00000406606.7 ENSP00000385362.3
ENSG00000160293.16 ENST00000371850.7 ENSP00000360916.3
ENSG00000160293.16 ENST00000371851.1 ENSP00000360917.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.00e-17 63.6 823 874
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 823  ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 874
           67**********************************..9*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
 Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Protein Sequence
(Fasta)
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046208|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGGATTGG GGAGCGCTGC GGCGACTGGC TGCGTGGAGC CCGGCCCGGG GCCCGCAGGC 60
ACTTGCGTGT GTGAAGCGGG GAGATCCGGC GCGCTGCCCG TTGCCCGCCC CGCGGCCGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046208|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0001525--P:angiogenesis
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0030032--P:lamellipodium assembly
GO:0030168--P:platelet activation
GO:0043065--P:positive regulation of apoptotic process
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
KEGG hsa:7410
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001437 Ailuropoda melanoleuca 93.29 0.00e+00 1485.00
IUUC-Apl-003262 Anas platyrhynchos 89.75 0.00e+00 1536.00
IUUC-Aca-004628 Anolis carolinensis 65.65 0.00e+00 910.00
IUUC-Ath-007352 Arabidopsis thaliana 38.60 7.00e-04 39.30
IUUC-Ame-011608 Astyanax mexicanus 79.59 0.00e+00 1430.00
IUUC-Bta-013147 Bos taurus 92.46 0.00e+00 1309.00
IUUC-Cel-018578 Caenorhabditis elegans 27.65 5.00e-96 346.00
IUUC-Cja-018877 Callithrix jacchus 93.72 0.00e+00 1432.00
IUUC-Cfa-020315 Canis familiaris 91.15 0.00e+00 1246.00
IUUC-Cpo-021543 Cavia porcellus 91.26 0.00e+00 1326.00
IUUC-Csa-024204 Chlorocebus sabaeus 97.66 0.00e+00 1683.00
IUUC-Cin-025115 Ciona intestinalis 36.30 3.00e-146 512.00
IUUC-Csv-025995 Ciona savignyi 35.80 3.00e-147 516.00
IUUC-Dre-028308 Danio rerio 81.88 0.00e+00 1472.00
IUUC-Dno-029584 Dasypus novemcinctus 87.11 0.00e+00 1144.00
IUUC-Dor-031014 Dipodomys ordii 81.64 0.00e+00 1223.00
IUUC-Eca-033448 Equus caballus 93.28 0.00e+00 1620.00
IUUC-Eeu-035182 Erinaceus europaeus 84.04 0.00e+00 677.00
IUUC-Fca-035460 Felis catus 91.62 0.00e+00 1324.00
IUUC-Fal-036684 Ficedula albicollis 90.70 0.00e+00 1590.00
IUUC-Gmo-038816 Gadus morhua 73.88 0.00e+00 1074.00
IUUC-Gga-040999 Gallus gallus 87.47 0.00e+00 1519.00
IUUC-Gac-041353 Gasterosteus aculeatus 75.06 0.00e+00 1124.00
IUUC-Ggo-044558 Gorilla gorilla 99.66 0.00e+00 1697.00
IUUC-Itr-047931 Ictidomys tridecemlineatus 89.11 0.00e+00 1197.00
IUUC-Loc-052827 Lepisosteus oculatus 81.63 0.00e+00 1470.00
IUUC-Laf-054009 Loxodonta africana 90.67 0.00e+00 1549.00
IUUC-Mcc-055054 Macaca mulatta 99.66 0.00e+00 1698.00
IUUC-Mla-059044 Melampsora laricipopulina 21.49 2.00e-19 91.70
IUUC-Mga-060106 Meleagris gallopavo 90.43 0.00e+00 1547.00
IUUC-Mmr-061118 Microcebus murinus 93.51 0.00e+00 1598.00
IUUC-Mdo-062380 Monodelphis domestica 87.97 0.00e+00 1296.00
IUUC-Mmu-063135 Mus musculus 94.76 0.00e+00 1643.00
IUUC-Mpu-066135 Mustela putorius furo 88.77 0.00e+00 1424.00
IUUC-Nle-069465 Nomascus leucogenys 90.90 0.00e+00 1512.00
IUUC-Ont-071945 Oreochromis niloticus 81.52 0.00e+00 1410.00
IUUC-Oan-073384 Ornithorhynchus anatinus 86.77 0.00e+00 1209.00
IUUC-Ola-087499 Oryzias latipes 74.76 0.00e+00 1056.00
IUUC-Oga-088444 Otolemur garnettii 91.36 0.00e+00 1301.00
IUUC-Oar-089576 Ovis aries 87.38 0.00e+00 1209.00
IUUC-Ptr-090507 Pan troglodytes 98.63 0.00e+00 1658.00
IUUC-Pan-092325 Papio anubis 94.99 0.00e+00 1595.00
IUUC-Psi-094021 Pelodiscus sinensis 87.46 0.00e+00 1507.00
IUUC-Pma-094372 Petromyzon marinus 52.74 0.00e+00 696.00
IUUC-Pfo-096732 Poecilia formosa 82.33 0.00e+00 1445.00
IUUC-Pab-098426 Pongo abelii 80.76 0.00e+00 1180.00
IUUC-Pca-100295 Procavia capensis 92.67 0.00e+00 1497.00
IUUC-Rno-105332 Rattus norvegicus 93.96 0.00e+00 1560.00
IUUC-Sha-106529 Sarcophilus harrisii 93.28 0.00e+00 1299.00
IUUC-Ssc-116176 Sus scrofa 92.66 0.00e+00 1449.00
IUUC-Tgu-116917 Taeniopygia guttata 89.89 0.00e+00 1409.00
IUUC-Tru-118398 Takifugu rubripes 78.64 0.00e+00 979.00
IUUC-Tni-120819 Tetraodon nigroviridis 78.87 0.00e+00 1190.00
IUUC-Xtr-132747 Xenopus tropicalis 78.27 0.00e+00 1348.00
Created Date 25-Jun-2017

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