iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000168556.6	ENST00000302327.3	ENSP00000307183.3
ENSG00000168556.6	ENST00000412117.1	ENSP00000410291.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.00e-08	36.8	213	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 213  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 259
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Homo sapiens

Functional Description
(View)

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Protein Sequence
(Fasta)

MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 60
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCCTGGG CTGGTGCTGC GGGGGCGGGG AGTGAGGGCT GCTCTGGGGG GAGTGGAGAT 60
CGGGGAGCGC GGCCGTGCCC TCTCGAGCGG CTGCGGGGTC CCCGCGGCGC CGGGCTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0035091--F:phosphatidylinositol binding
GO:0032403--F:protein complex binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:0008285--P:negative regulation of cell proliferation
GO:1902166--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0040008--P:regulation of growth
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0072520--P:seminiferous tubule development
GO:0007165--P:signal transduction
GO:0007286--P:spermatid development
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:3622

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	97.86	5.00e-120	423.00
IUUC-Apl-003705	Anas platyrhynchos	88.79	6.00e-91	326.00
IUUC-Aca-004990	Anolis carolinensis	81.47	7.00e-98	350.00
IUUC-Ame-011426	Astyanax mexicanus	71.17	3.00e-84	304.00
IUUC-Bta-012721	Bos taurus	98.16	4.00e-119	420.00
IUUC-Cja-018960	Callithrix jacchus	99.24	9.00e-108	382.00
IUUC-Cfa-020869	Canis familiaris	97.50	2.00e-119	422.00
IUUC-Cpo-021414	Cavia porcellus	96.07	6.00e-118	416.00
IUUC-Csa-023304	Chlorocebus sabaeus	100.00	4.00e-115	407.00
IUUC-Dre-028562	Danio rerio	69.96	3.00e-88	318.00
IUUC-Dno-029945	Dasypus novemcinctus	97.73	2.00e-114	405.00
IUUC-Dor-030141	Dipodomys ordii	96.43	5.00e-117	413.00
IUUC-Ete-032709	Echinops telfairi	95.76	6.00e-128	449.00
IUUC-Eca-033432	Equus caballus	98.53	6.00e-119	420.00
IUUC-Eeu-035285	Erinaceus europaeus	98.04	2.00e-89	322.00
IUUC-Fca-036467	Felis catus	98.11	4.00e-114	404.00
IUUC-Fal-036700	Ficedula albicollis	87.56	4.00e-90	323.00
IUUC-Gmo-038748	Gadus morhua	63.41	3.00e-85	308.00
IUUC-Gga-040175	Gallus gallus	88.34	1.00e-90	326.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	2.00e-89	322.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.86	6.00e-120	423.00
IUUC-Lch-049965	Latimeria chalumnae	80.92	2.00e-99	355.00
IUUC-Laf-053353	Loxodonta africana	96.89	2.00e-100	357.00
IUUC-Mcc-055155	Macaca mulatta	100.00	2.00e-74	271.00
IUUC-Meu-056470	Macropus eugenii	94.09	1.00e-111	395.00
IUUC-Mga-059570	Meleagris gallopavo	88.34	5.00e-90	323.00
IUUC-Mmr-061385	Microcebus murinus	99.64	1.00e-114	405.00
IUUC-Mdo-062144	Monodelphis domestica	94.14	5.00e-113	400.00
IUUC-Mmu-063215	Mus musculus	96.44	4.00e-118	417.00
IUUC-Mpu-065749	Mustela putorius furo	97.07	7.00e-98	349.00
IUUC-Mlu-067245	Myotis lucifugus	75.49	3.00e-81	294.00
IUUC-Nle-069968	Nomascus leucogenys	99.47	4.00e-83	300.00
IUUC-Ont-071524	Oreochromis niloticus	66.30	1.00e-86	313.00
IUUC-Ocu-074870	Oryctolagus cuniculus	97.53	2.00e-119	421.00
IUUC-Ola-087400	Oryzias latipes	89.02	2.00e-44	172.00
IUUC-Oga-088336	Otolemur garnettii	98.23	2.00e-112	398.00
IUUC-Oar-090136	Ovis aries	97.78	1.00e-117	415.00
IUUC-Ptr-091348	Pan troglodytes	100.00	9.00e-84	303.00
IUUC-Pan-092819	Papio anubis	100.00	4.00e-115	407.00
IUUC-Psi-093854	Pelodiscus sinensis	86.21	6.00e-63	233.00
IUUC-Pfo-096633	Poecilia formosa	63.79	1.00e-80	293.00
IUUC-Pab-098346	Pongo abelii	99.64	1.00e-114	405.00
IUUC-Pca-100278	Procavia capensis	95.67	1.00e-116	412.00
IUUC-Pva-103190	Pteropus vampyrus	98.86	2.00e-115	407.00
IUUC-Rno-104940	Rattus norvegicus	96.59	9.00e-113	399.00
IUUC-Sha-107533	Sarcophilus harrisii	92.28	6.00e-114	403.00
IUUC-Sar-113630	Sorex araneus	96.08	1.00e-88	319.00
IUUC-Ssc-115734	Sus scrofa	98.86	3.00e-115	407.00
IUUC-Tgu-117034	Taeniopygia guttata	88.00	1.00e-90	325.00
IUUC-Tru-118168	Takifugu rubripes	60.34	1.00e-81	296.00
IUUC-Tsy-119494	Tarsius syrichta	99.51	3.00e-83	301.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.25	4.00e-77	281.00
IUUC-Ttr-128442	Tursiops truncatus	98.53	6.00e-90	323.00
IUUC-Vpa-130063	Vicugna pacos	97.50	1.00e-119	422.00
IUUC-Xtr-132348	Xenopus tropicalis	70.36	1.00e-68	253.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence