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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018578
Ensembl Protein ID C35B8.2b
UniProt Accession Q45FX5; Q18479; VAV_CAEEL
Genbank Protein ID AAZ66767.1; CCD66769.1; CCD66770.1
Protein Name Protein vav-1
Genbank Nucleotide ID DQ136172; FO080787; FO080787
Gene Name vav-1; C35B8.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006887 C35B8.2b C35B8.2b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBasemicroRNATRANSFACmiRecords
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-11 44.7 929 988
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqndde....LtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++++ +dy+a + ++    L++k Gd+v +++   +d gW+kg  + ++k+G+fP  +v+ 
   Q: 929  KVFKAVHDYDAPSPNNegkfLSFKTGDIVVLLDTVGEDRGWWKG--QVNNKSGFFPLSYVKP 988
           6789*****98654433668************************..7************986 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium.
 Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium.
Protein Sequence
(Fasta)
MSRRSTTTST NFGLSWSLVD VISSSTAVFK VPMNGGCDLW IGCARWLRDM KVLTTDKNGT 60
MLEFASVLRD GILLCRLANT LVPNGIDQKK IMRTNQPSPF LCCNNINYFA MFCKTYFNLE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018578|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACAATGTCG CGCCGCAGCA CAACAACATC CACTAATTTT GGGCTCTCGT GGAGCCTCGT 60
CGATGTTATT TCAAGTAGTA CCGCAGTTTT TAAGGTTAGT TGGCATTTAT TTTGAAAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018578|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0040017--P:positive regulation of locomotion
GO:0035023--P:regulation of Rho protein signal transduction
GO:0040028--P:regulation of vulval development
KEGG cel:CELE_C35B8.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001437 Ailuropoda melanoleuca 29.39 8.00e-60 224.00
IUUC-Apl-003734 Anas platyrhynchos 27.74 9.00e-72 263.00
IUUC-Aca-004477 Anolis carolinensis 30.20 2.00e-68 253.00
IUUC-Ath-007326 Arabidopsis thaliana 31.58 2.00e-03 35.80
IUUC-Ago-008003 Ashbya gossypii 21.96 2.00e-09 56.60
IUUC-Acl-008142 Aspergillus clavatus 24.05 2.00e-11 63.20
IUUC-Afl-008481 Aspergillus flavus 22.86 4.00e-12 65.90
IUUC-Afu-009099 Aspergillus fumigatus 23.91 5.00e-11 62.00
IUUC-Ani-009276 Aspergillus nidulans 22.85 2.00e-11 63.20
IUUC-Ang-009549 Aspergillus niger 24.64 2.00e-11 63.50
IUUC-Aor-010216 Aspergillus oryzae 22.86 4.00e-12 65.90
IUUC-Ate-010338 Aspergillus terreus 23.05 2.00e-10 60.10
IUUC-Ame-011608 Astyanax mexicanus 29.82 1.00e-100 359.00
IUUC-Bgr-012058 Blumeria graminis 24.91 2.00e-11 63.50
IUUC-Bta-012722 Bos taurus 28.69 9.00e-64 237.00
IUUC-Bci-013634 Botrytis cinerea 25.00 2.00e-10 60.80
IUUC-Cja-020009 Callithrix jacchus 28.56 2.00e-86 312.00
IUUC-Cfa-020315 Canis familiaris 28.14 8.00e-68 250.00
IUUC-Cpo-021543 Cavia porcellus 29.69 9.00e-44 170.00
IUUC-Csa-024204 Chlorocebus sabaeus 29.53 8.00e-69 254.00
IUUC-Cho-025069 Choloepus hoffmanni 26.50 2.00e-22 100.00
IUUC-Cin-025115 Ciona intestinalis 29.91 2.00e-61 229.00
IUUC-Csv-025995 Ciona savignyi 29.09 1.00e-66 246.00
IUUC-Cgl-026579 Colletotrichum gloeosporioides 27.05 2.00e-08 53.50
IUUC-Cne-027023 Cryptococcus neoformans 26.37 2.00e-15 77.00
IUUC-Cme-027247 Cyanidioschyzon merolae 25.49 8.00e-10 57.40
IUUC-Dre-028308 Danio rerio 29.01 2.00e-98 352.00
IUUC-Dno-029474 Dasypus novemcinctus 28.61 1.00e-64 239.00
IUUC-Dor-031014 Dipodomys ordii 24.46 9.00e-55 207.00
IUUC-Dse-031545 Dothistroma septosporum 23.62 1.00e-03 38.10
IUUC-Ete-032545 Echinops telfairi 29.41 5.00e-24 105.00
IUUC-Eca-033448 Equus caballus 28.77 3.00e-64 239.00
IUUC-Eeu-035182 Erinaceus europaeus 27.98 1.00e-39 157.00
IUUC-Fca-035629 Felis catus 28.93 2.00e-94 338.00
IUUC-Fal-036802 Ficedula albicollis 27.55 4.00e-81 295.00
IUUC-Fso-038080 Fusarium solani 23.66 2.00e-12 66.60
IUUC-Gmo-039409 Gadus morhua 30.37 2.00e-69 255.00
IUUC-Gga-040884 Gallus gallus 28.36 4.00e-83 301.00
IUUC-Gac-041395 Gasterosteus aculeatus 27.06 2.00e-85 309.00
IUUC-Ggo-044558 Gorilla gorilla 29.70 7.00e-70 257.00
IUUC-Hsa-046208 Homo sapiens 30.54 3.00e-70 258.00
IUUC-Itr-047931 Ictidomys tridecemlineatus 26.94 1.00e-65 242.00
IUUC-Kpa-049278 Komagataella pastoris 23.73 7.00e-09 54.70
IUUC-Lch-049650 Latimeria chalumnae 35.23 6.00e-24 102.00
IUUC-Loc-052827 Lepisosteus oculatus 28.20 1.00e-98 353.00
IUUC-Lma-052955 Leptosphaeria maculans 25.18 4.00e-15 75.90
IUUC-Laf-054537 Loxodonta africana 30.70 4.00e-73 268.00
IUUC-Mcc-055054 Macaca mulatta 30.54 3.00e-70 259.00
IUUC-Meu-056680 Macropus eugenii 29.22 2.00e-61 229.00
IUUC-Mla-059044 Melampsora laricipopulina 21.48 6.00e-15 75.50
IUUC-Mga-060013 Meleagris gallopavo 29.18 2.00e-91 329.00
IUUC-Mvi-060486 Microbotryum violaceum 22.42 2.00e-17 83.60
IUUC-Mmr-061118 Microcebus murinus 27.48 5.00e-88 317.00
IUUC-Mdo-062380 Monodelphis domestica 26.64 9.00e-68 250.00
IUUC-Mmu-063135 Mus musculus 27.84 6.00e-81 294.00
IUUC-Mpu-066135 Mustela putorius furo 27.59 4.00e-79 288.00
IUUC-Mlu-068108 Myotis lucifugus 27.93 3.00e-62 232.00
IUUC-Nfi-068331 Neosartorya fischeri 23.91 3.00e-11 62.80
IUUC-Nle-069863 Nomascus leucogenys 28.03 6.00e-61 227.00
IUUC-Opr-070372 Ochotona princeps 25.80 4.00e-47 181.00
IUUC-Ont-071945 Oreochromis niloticus 33.91 9.00e-74 270.00
IUUC-Oan-073384 Ornithorhynchus anatinus 29.94 4.00e-44 171.00
IUUC-Ocu-074194 Oryctolagus cuniculus 30.59 1.00e-65 243.00
IUUC-Ola-086336 Oryzias latipes 29.51 7.00e-70 257.00
IUUC-Oga-088444 Otolemur garnettii 26.46 2.00e-60 226.00
IUUC-Oar-089272 Ovis aries 28.81 3.00e-66 245.00
IUUC-Ptr-090507 Pan troglodytes 30.35 9.00e-70 257.00
IUUC-Pan-092325 Papio anubis 30.19 1.00e-68 253.00
IUUC-Psi-094021 Pelodiscus sinensis 27.10 2.00e-82 299.00
IUUC-Pma-094372 Petromyzon marinus 26.32 6.00e-59 221.00
IUUC-Pfo-096732 Poecilia formosa 28.87 2.00e-92 332.00
IUUC-Pab-098630 Pongo abelii 28.26 8.00e-81 293.00
IUUC-Pca-100295 Procavia capensis 27.46 2.00e-75 276.00
IUUC-Pva-102262 Pteropus vampyrus 30.37 2.00e-65 242.00
IUUC-Pgr-103473 Puccinia graminis 26.43 3.00e-17 84.00
IUUC-Ptt-103973 Puccinia triticina 29.30 8.00e-15 75.90
IUUC-Pte-104293 Pyrenophora teres 24.67 1.00e-14 74.30
IUUC-Pyt-104722 Pyrenophora triticirepentis 25.41 7.00e-15 74.70
IUUC-Rno-105332 Rattus norvegicus 29.87 5.00e-67 248.00
IUUC-Sce-106197 Saccharomyces cerevisiae 20.48 3.00e-10 59.30
IUUC-Sha-107325 Sarcophilus harrisii 30.20 4.00e-70 258.00
IUUC-Sja-107728 Schizosaccharomyces japonicus 28.57 2.00e-06 46.60
IUUC-Spo-108284 Schizosaccharomyces pombe 24.34 1.00e-11 64.30
IUUC-Ssl-108541 Sclerotinia sclerotiorum 25.37 2.00e-11 63.50
IUUC-Sar-113456 Sorex araneus 26.61 3.00e-54 205.00
IUUC-Sre-115126 Sporisorium reilianum 25.83 4.00e-18 85.90
IUUC-Ssc-116176 Sus scrofa 28.17 4.00e-54 204.00
IUUC-Tgu-116595 Taeniopygia guttata 28.44 3.00e-83 301.00
IUUC-Tru-118577 Takifugu rubripes 26.62 2.00e-78 286.00
IUUC-Tsy-119429 Tarsius syrichta 28.42 3.00e-46 179.00
IUUC-Tni-120548 Tetraodon nigroviridis 31.48 3.00e-66 245.00
IUUC-Tre-121935 Trichoderma reesei 25.13 5.00e-13 68.90
IUUC-Tvi-122300 Trichoderma virens 25.75 2.00e-13 70.50
IUUC-Tme-127216 Tuber melanosporum 25.43 8.00e-20 91.70
IUUC-Tbe-127995 Tupaia belangeri 27.59 4.00e-35 142.00
IUUC-Ttr-128281 Tursiops truncatus 29.00 3.00e-64 238.00
IUUC-Uma-129594 Ustilago maydis 25.09 3.00e-16 79.70
IUUC-Vpa-130750 Vicugna pacos 27.60 1.00e-22 101.00
IUUC-Xtr-132747 Xenopus tropicalis 33.02 3.00e-72 265.00
IUUC-Xma-133428 Xiphophorus maculatus 29.97 1.00e-70 259.00
Created Date 25-Jun-2017

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