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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063643
Ensembl Protein ID ENSMUSP00000094084.5
UniProt Accession P97369; Q3TBC6; NCF4_MOUSE
Genbank Protein ID AAC53122.1; BAA25651.1; BAE29623.1; BAE42387.1; CAP19156.1; EDL29666.1; AAH25517.1
Protein Name Neutrophil cytosol factor 4; Neutrophil NADPH oxidase factor 4; p40-phox
Genbank Nucleotide ID U59488; AB002665; AK150510; AK171315; AL589692; CH466545; BC025517
Gene Name Ncf4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000071715.11 ENSMUST00000096357.11 ENSMUSP00000094084.5
ENSMUSG00000071715.11 ENSMUST00000133618.1 ENSMUSP00000121191.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.40e-11 43.7 175 228
ULD/UDP/UFD/PB1 1.30e-19 71.3 237 329
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            ++l+d++++++ eL++k+Gdv++++   + +++Wl+g  + +g  G+fP  Fv+ l+
   Q: 175  AEALFDFTGNSKLELSFKAGDVIFLL--SKINKDWLEG--TSQGATGIFPGSFVKILK 228
           689***********************..8999******..89************9876 PP
   

   ULD/UDP/UFD/PB1
   S: 1    tvrvkvsykgeirs......faldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksll..r 78
           t+++++++++++        +++dl+++++f+dLl+++r+  e++++++al Y+D++GDlv+l sDed+  +v++++   s+k+l+  +
   Q: 237  TNWLRCYFYEDTGKtikdiaVEEDLSSTPLFKDLLALMRR--EFQREDIALSYQDAEGDLVRLLSDEDVGLMVKQARglpSQKRLFpwK 323
           589*********9999************************..********************************************999 PP
   S: 79   lliqkk 84
           l++++k
   Q: 324  LHVTQK 329
           *99985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
 Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
Protein Sequence
(Fasta)
MALAQQLRSE SDFEQLPDDV AVSANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR 60
QFYALQSKLE ERFGPESKNS PFTCSLPTLP AKVYMGAKQE IAETRIPALN AYMKNLLSLP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063643|UBD,SH3;ULD,PB1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCCTCAAC TGCTGTGCAG CTGGGAAGTG GCTGAGAAGA CGTGTGAGGG CCAGGCAGCT 60
CAAAGCCTGA AGGAGGTACT TCAAGGAGGG TCCAGAGAAG CTGGGCAGGG CGGGACCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063643|UBD,SH3;ULD,PB1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR000919--NCF_P40
IPR000270--PB1_dom
IPR001683--Phox
IPR001452--SH3_domain
PROSITE

PS51745--PB1
PS50195--PX
PS50002--SH3
Pfam

PF00564--PB1
PF00787--PX
PF00018--SH3_1
PRINTS

PR00497--P40PHOX
PR00452--SH3DOMAIN
SMART

SM00666--PB1
SM00312--PX
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0005802--C:trans-Golgi network
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0016192--P:vesicle-mediated transport
KEGG mmu:17972
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001675 Ailuropoda melanoleuca 86.14 1.00e-174 605.00
IUUC-Apl-003431 Anas platyrhynchos 66.67 3.00e-135 474.00
IUUC-Aca-005176 Anolis carolinensis 70.83 6.00e-136 476.00
IUUC-Ame-011492 Astyanax mexicanus 58.59 5.00e-116 410.00
IUUC-Bta-013434 Bos taurus 87.02 9.00e-162 562.00
IUUC-Cja-019788 Callithrix jacchus 85.84 2.00e-174 604.00
IUUC-Cfa-021039 Canis familiaris 86.14 7.00e-169 586.00
IUUC-Cpo-021848 Cavia porcellus 85.25 8.00e-168 582.00
IUUC-Csa-023733 Chlorocebus sabaeus 85.71 7.00e-151 526.00
IUUC-Dre-027732 Danio rerio 53.09 8.00e-100 357.00
IUUC-Dno-029154 Dasypus novemcinctus 78.07 3.00e-152 530.00
IUUC-Eca-034062 Equus caballus 86.14 2.00e-168 584.00
IUUC-Eeu-035129 Erinaceus europaeus 72.48 1.00e-59 223.00
IUUC-Fca-036402 Felis catus 87.32 3.00e-177 614.00
IUUC-Fal-037105 Ficedula albicollis 68.14 1.00e-136 479.00
IUUC-Gmo-039144 Gadus morhua 53.75 5.00e-36 143.00
IUUC-Gga-040526 Gallus gallus 67.26 2.00e-134 472.00
IUUC-Ggo-044667 Gorilla gorilla 85.27 2.00e-130 458.00
IUUC-Hsa-045779 Homo sapiens 86.73 7.00e-177 612.00
IUUC-Itr-048385 Ictidomys tridecemlineatus 73.10 6.00e-135 473.00
IUUC-Lch-050264 Latimeria chalumnae 52.41 6.00e-113 400.00
IUUC-Loc-051887 Lepisosteus oculatus 55.08 1.00e-106 379.00
IUUC-Laf-054411 Loxodonta africana 79.52 9.00e-150 522.00
IUUC-Mcc-055835 Macaca mulatta 86.59 5.00e-171 593.00
IUUC-Meu-056875 Macropus eugenii 79.29 2.00e-92 331.00
IUUC-Mga-059737 Meleagris gallopavo 66.67 5.00e-134 470.00
IUUC-Mmr-061065 Microcebus murinus 83.68 2.00e-118 418.00
IUUC-Mdo-062598 Monodelphis domestica 78.82 1.00e-154 539.00
IUUC-Mpu-066142 Mustela putorius furo 87.91 4.00e-179 620.00
IUUC-Mlu-067898 Myotis lucifugus 87.78 4.00e-45 172.00
IUUC-Nle-069935 Nomascus leucogenys 74.19 8.00e-140 489.00
IUUC-Opr-070204 Ochotona princeps 83.46 1.00e-129 456.00
IUUC-Ont-072261 Oreochromis niloticus 54.29 4.00e-106 377.00
IUUC-Oan-072846 Ornithorhynchus anatinus 79.62 1.00e-73 268.00
IUUC-Ocu-074683 Oryctolagus cuniculus 87.65 3.00e-177 613.00
IUUC-Ogu-079036 Oryza glumaepatula 40.00 5.50e-01 26.60
IUUC-Ola-086700 Oryzias latipes 53.58 7.00e-97 347.00
IUUC-Oga-087992 Otolemur garnettii 87.09 4.00e-171 593.00
IUUC-Oar-089828 Ovis aries 86.22 2.00e-159 554.00
IUUC-Pan-092264 Papio anubis 86.73 8.00e-177 612.00
IUUC-Psi-093800 Pelodiscus sinensis 66.08 1.00e-129 456.00
IUUC-Pfo-096677 Poecilia formosa 51.12 2.00e-88 319.00
IUUC-Pab-097920 Pongo abelii 86.43 7.00e-177 612.00
IUUC-Pca-100312 Procavia capensis 69.23 7.00e-96 343.00
IUUC-Pva-102113 Pteropus vampyrus 84.94 1.00e-130 459.00
IUUC-Rno-105777 Rattus norvegicus 97.35 0.00e+00 684.00
IUUC-Sha-106666 Sarcophilus harrisii 78.53 1.00e-161 561.00
IUUC-Ssc-116056 Sus scrofa 86.43 3.00e-178 617.00
IUUC-Tgu-116797 Taeniopygia guttata 68.44 2.00e-138 485.00
IUUC-Tru-117860 Takifugu rubripes 53.89 1.00e-97 350.00
IUUC-Tsy-119537 Tarsius syrichta 84.24 5.00e-80 291.00
IUUC-Tni-119946 Tetraodon nigroviridis 55.68 1.00e-99 356.00
IUUC-Tbe-127274 Tupaia belangeri 75.00 1.00e-107 382.00
IUUC-Ttr-129026 Tursiops truncatus 87.08 3.00e-107 381.00
IUUC-Xtr-131910 Xenopus tropicalis 52.21 8.00e-107 380.00
Created Date 25-Jun-2017

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