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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063374
UUCD1 version UUC-MuM-00992
Ensembl Protein ID ENSMUSP00000064929.5
UniProt Accession Q9JLY0; Q8VEN5; Q9D2A0; SOCS6_MOUSE
Genbank Protein ID AAF28872.1; BAB31956.1; BAC26055.1; BAC26074.1; BAC27287.1; BAC32154.1; BAE24930.1; BAE33770.1; EDL00645.1; EDL00646.1; AAH17597.1; AAH94443.1
Protein Name Suppressor of cytokine signaling 6; Cytokine-inducible SH2 protein 4; Suppressor of cytokine signaling 4
Genbank Nucleotide ID AF121907; AK019993; AK028665; AK028701; AK031164; AK044946; AK142069; AK156591; CH466632; CH466632; BC017597; BC094443
Gene Name Socs6; Cis4; Cish4; Socs4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000056153.14 ENSMUST00000070116.11 ENSMUSP00000064929.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 6.00e-17 62.4 486 533
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 486  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 533
           5788999********************888...***************997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
Protein Sequence
(Fasta)
MKKISLKTFR KSFNLSKSKD ETEFMVVQPQ SLAGDFVKDD SLFGSCYGKD MASCDIGSED 60
EKGKNRSKSE SLMGTLKRRL SAKQKTKGKG GTASTDEDTF SSASAPGGLK DVRAPRPIRS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063374|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGAGGTCAA AGGACACAGA GGGAAGCTCA CCCAGTGCTG CTGCTGCTGC TGCTGCTGCT 60
GTGGGCCTTC TGACTGGAAC CAGAAACAAA GGTACTGAGA ACTTGTAGGT AACTCTTTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063374|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
KEGG mmu:54607
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001911 Ailuropoda melanoleuca 82.71 0.00e+00 804.00
IUUC-Atr-002940 Amborella trichopoda 29.73 1.00e-02 34.30
IUUC-Apl-004035 Anas platyrhynchos 80.11 0.00e+00 764.00
IUUC-Aca-004782 Anolis carolinensis 79.22 0.00e+00 747.00
IUUC-Ame-011790 Astyanax mexicanus 64.27 8.00e-164 570.00
IUUC-Bta-012579 Bos taurus 95.69 4.00e-109 388.00
IUUC-Bol-015843 Brassica oleracea 28.77 4.10e-02 32.70
IUUC-Cel-018643 Caenorhabditis elegans 33.59 1.00e-11 62.80
IUUC-Cja-019528 Callithrix jacchus 84.79 0.00e+00 849.00
IUUC-Cfa-020678 Canis familiaris 83.64 0.00e+00 824.00
IUUC-Cpo-021947 Cavia porcellus 83.46 0.00e+00 847.00
IUUC-Csa-023935 Chlorocebus sabaeus 84.39 0.00e+00 829.00
IUUC-Cho-024477 Choloepus hoffmanni 80.89 0.00e+00 812.00
IUUC-Cin-025413 Ciona intestinalis 68.24 5.00e-66 244.00
IUUC-Csv-026247 Ciona savignyi 67.47 1.00e-64 240.00
IUUC-Dre-027636 Danio rerio 64.52 5.00e-165 573.00
IUUC-Dno-029048 Dasypus novemcinctus 83.49 0.00e+00 818.00
IUUC-Dor-030401 Dipodomys ordii 81.23 0.00e+00 808.00
IUUC-Ete-033116 Echinops telfairi 47.52 5.00e-55 207.00
IUUC-Eca-033825 Equus caballus 82.53 0.00e+00 796.00
IUUC-Fca-036253 Felis catus 78.75 0.00e+00 746.00
IUUC-Fal-037614 Ficedula albicollis 80.48 0.00e+00 768.00
IUUC-Fox-037898 Fusarium oxysporum 24.49 2.90e-01 28.90
IUUC-Gmo-038928 Gadus morhua 65.56 1.00e-174 605.00
IUUC-Gga-040177 Gallus gallus 79.93 0.00e+00 764.00
IUUC-Gac-042263 Gasterosteus aculeatus 65.20 5.00e-180 624.00
IUUC-Ggo-045288 Gorilla gorilla 84.20 0.00e+00 830.00
IUUC-Hsa-046409 Homo sapiens 84.39 0.00e+00 830.00
IUUC-Itr-048996 Ictidomys tridecemlineatus 82.34 0.00e+00 796.00
IUUC-Lch-050354 Latimeria chalumnae 75.32 0.00e+00 761.00
IUUC-Loc-052319 Lepisosteus oculatus 73.28 0.00e+00 727.00
IUUC-Laf-054070 Loxodonta africana 82.16 0.00e+00 783.00
IUUC-Mcc-055045 Macaca mulatta 84.76 0.00e+00 834.00
IUUC-Meu-055917 Macropus eugenii 80.48 0.00e+00 823.00
IUUC-Mga-059273 Meleagris gallopavo 80.30 0.00e+00 762.00
IUUC-Mmr-061597 Microcebus murinus 83.83 0.00e+00 822.00
IUUC-Mdo-062492 Monodelphis domestica 53.80 5.00e-82 297.00
IUUC-Mpu-065967 Mustela putorius furo 81.04 0.00e+00 793.00
IUUC-Mlu-067532 Myotis lucifugus 81.97 0.00e+00 809.00
IUUC-Nle-069373 Nomascus leucogenys 84.20 0.00e+00 828.00
IUUC-Opr-070873 Ochotona princeps 82.53 0.00e+00 842.00
IUUC-Ont-072498 Oreochromis niloticus 66.18 0.00e+00 659.00
IUUC-Oan-072943 Ornithorhynchus anatinus 69.20 2.00e-89 322.00
IUUC-Ocu-073870 Oryctolagus cuniculus 83.09 0.00e+00 825.00
IUUC-Ola-086866 Oryzias latipes 90.32 9.00e-105 372.00
IUUC-Oga-089057 Otolemur garnettii 81.63 0.00e+00 801.00
IUUC-Oar-089841 Ovis aries 60.07 2.00e-160 558.00
IUUC-Ptr-091054 Pan troglodytes 84.57 0.00e+00 832.00
IUUC-Pma-094253 Petromyzon marinus 82.11 9.00e-92 330.00
IUUC-Pfo-097179 Poecilia formosa 62.18 1.00e-162 566.00
IUUC-Pab-097702 Pongo abelii 84.20 0.00e+00 827.00
IUUC-Pca-100671 Procavia capensis 71.53 5.00e-99 354.00
IUUC-Rno-106044 Rattus norvegicus 96.53 0.00e+00 969.00
IUUC-Sha-107139 Sarcophilus harrisii 79.44 0.00e+00 745.00
IUUC-Smo-108823 Selaginella moellendorffii 33.96 3.50e-02 32.00
IUUC-Ssc-115343 Sus scrofa 84.60 0.00e+00 837.00
IUUC-Tgu-117061 Taeniopygia guttata 80.30 0.00e+00 768.00
IUUC-Tni-119829 Tetraodon nigroviridis 61.88 2.00e-168 585.00
IUUC-Ttr-129148 Tursiops truncatus 81.26 0.00e+00 770.00
IUUC-Vpa-130780 Vicugna pacos 81.56 0.00e+00 775.00
IUUC-Vvi-130966 Vitis vinifera 32.69 5.70e-02 31.20
IUUC-Xtr-132513 Xenopus tropicalis 74.12 0.00e+00 736.00
Created Date 25-Jun-2017

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