iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	17997974

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-16	61.7	378	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+s+k YL++++y+
   Q: 378  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSSMKLYLKEYHYK 425
           678899***********************...****************985 PP

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

Protein Sequence
(Fasta)

MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 60
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAACACGG AAGTGGTGGC GGCGCCCAGG GAACCGGCGG AGGCGATGAC CGTGACGGCT 60
GGGTTGGGAC CGGAACGCCG AAGCGGGGTT GGGGGTGGCA GAAAAGCATC TGCTTTGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

hsa:122809

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	93.39	0.00e+00	787.00
IUUC-Apl-003839	Anas platyrhynchos	79.04	0.00e+00	634.00
IUUC-Aca-004840	Anolis carolinensis	80.18	0.00e+00	701.00
IUUC-Bta-012503	Bos taurus	92.97	0.00e+00	783.00
IUUC-Bol-016597	Brassica oleracea	31.03	7.30e-02	32.30
IUUC-Cja-019284	Callithrix jacchus	97.73	0.00e+00	828.00
IUUC-Cfa-020890	Canis familiaris	93.41	0.00e+00	799.00
IUUC-Cpo-022081	Cavia porcellus	78.79	0.00e+00	672.00
IUUC-Csa-023076	Chlorocebus sabaeus	98.86	0.00e+00	835.00
IUUC-Cho-024700	Choloepus hoffmanni	93.42	0.00e+00	830.00
IUUC-Dno-029961	Dasypus novemcinctus	94.10	0.00e+00	829.00
IUUC-Dor-030273	Dipodomys ordii	92.74	0.00e+00	796.00
IUUC-Ete-032972	Echinops telfairi	91.99	6.00e-169	586.00
IUUC-Eca-034289	Equus caballus	93.88	0.00e+00	794.00
IUUC-Eeu-035208	Erinaceus europaeus	89.75	0.00e+00	746.00
IUUC-Fal-036829	Ficedula albicollis	79.27	0.00e+00	632.00
IUUC-Gga-040725	Gallus gallus	78.59	0.00e+00	662.00
IUUC-Ggo-044886	Gorilla gorilla	99.77	0.00e+00	845.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	93.56	0.00e+00	791.00
IUUC-Lch-049459	Latimeria chalumnae	57.08	2.00e-137	481.00
IUUC-Laf-053484	Loxodonta africana	94.48	0.00e+00	786.00
IUUC-Mcc-054890	Macaca mulatta	98.64	0.00e+00	833.00
IUUC-Meu-056532	Macropus eugenii	84.05	0.00e+00	638.00
IUUC-Mtr-057670	Medicago truncatula	36.67	2.60e+00	26.60
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.50e-02	33.10
IUUC-Mmr-061714	Microcebus murinus	95.92	0.00e+00	805.00
IUUC-Mmu-063161	Mus musculus	86.79	0.00e+00	740.00
IUUC-Mac-064598	Musa acuminata	27.94	2.40e-02	32.00
IUUC-Mpu-066499	Mustela putorius furo	93.86	0.00e+00	822.00
IUUC-Mlu-066945	Myotis lucifugus	92.74	0.00e+00	781.00
IUUC-Nle-069976	Nomascus leucogenys	99.32	0.00e+00	841.00
IUUC-Opr-070255	Ochotona princeps	87.30	0.00e+00	747.00
IUUC-Ocu-074764	Oryctolagus cuniculus	92.74	0.00e+00	786.00
IUUC-Oga-088910	Otolemur garnettii	88.24	0.00e+00	770.00
IUUC-Oar-090330	Ovis aries	92.97	0.00e+00	780.00
IUUC-Ptr-090709	Pan troglodytes	99.77	0.00e+00	845.00
IUUC-Pan-092540	Papio anubis	98.86	0.00e+00	835.00
IUUC-Psi-093678	Pelodiscus sinensis	80.87	0.00e+00	715.00
IUUC-Pab-097970	Pongo abelii	98.66	0.00e+00	700.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.40e-01	31.20
IUUC-Pca-100211	Procavia capensis	82.31	0.00e+00	664.00
IUUC-Rno-106014	Rattus norvegicus	84.97	0.00e+00	733.00
IUUC-Sha-106822	Sarcophilus harrisii	84.05	0.00e+00	720.00
IUUC-Ssc-115821	Sus scrofa	93.20	0.00e+00	787.00
IUUC-Tgu-117117	Taeniopygia guttata	79.73	0.00e+00	636.00
IUUC-Tsy-118979	Tarsius syrichta	97.05	2.00e-128	451.00
IUUC-Tca-121131	Theobroma cacao	30.77	3.00e-03	36.20
IUUC-Vpa-130626	Vicugna pacos	92.97	0.00e+00	791.00
IUUC-Vvi-131327	Vitis vinifera	43.75	1.10e-01	31.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence