iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.60e-09	36.7	214	260

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 214  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 260
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Mus musculus

Functional Description
(View)

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).

Protein Sequence
(Fasta)

MLGQQQQQQL YSSAALLTGE RSRLLSCYVQ DYLECVESLP HDMQRNVSVL RELDNKYQET 60
LKEIDDVYEK YKKEDDSNQK KRLQQHLQRA LINSQELGDE KIQIVTQMLE LVENRARQME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGAGGCTC GCGAGGGAGG CGCTGGATCC GCCAGATGGA GGCAAGGTCG GTAACTCGGG 60
GCCGAGCGAG CCGAGCCGGC GCTTCCTATC CCTGTAGGGG AACAGAAACG AAGAGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0035091--F:phosphatidylinositol binding
GO:0032403--F:protein complex binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:69260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	96.44	5.00e-119	420.00
IUUC-Apl-003705	Anas platyrhynchos	88.34	4.00e-91	327.00
IUUC-Aca-004990	Anolis carolinensis	81.47	4.00e-98	350.00
IUUC-Ame-011426	Astyanax mexicanus	70.07	2.00e-83	301.00
IUUC-Bta-012721	Bos taurus	97.79	1.00e-120	425.00
IUUC-Cja-018960	Callithrix jacchus	96.59	1.00e-105	375.00
IUUC-Cfa-020869	Canis familiaris	96.69	9.00e-119	419.00
IUUC-Cpo-021414	Cavia porcellus	95.37	6.00e-118	416.00
IUUC-Csa-023304	Chlorocebus sabaeus	96.44	3.00e-110	390.00
IUUC-Dre-028562	Danio rerio	67.16	9.00e-88	316.00
IUUC-Dno-029945	Dasypus novemcinctus	96.59	7.00e-115	406.00
IUUC-Dor-030141	Dipodomys ordii	96.09	2.00e-117	414.00
IUUC-Ete-032709	Echinops telfairi	94.85	7.00e-127	446.00
IUUC-Eca-033432	Equus caballus	97.43	2.00e-119	422.00
IUUC-Eeu-035285	Erinaceus europaeus	96.59	4.00e-90	323.00
IUUC-Fca-036467	Felis catus	96.97	1.00e-114	405.00
IUUC-Fal-036700	Ficedula albicollis	87.11	2.00e-90	324.00
IUUC-Gmo-038748	Gadus morhua	62.32	1.00e-84	306.00
IUUC-Gga-040175	Gallus gallus	87.89	6.00e-91	326.00
IUUC-Gac-041403	Gasterosteus aculeatus	63.87	2.00e-89	322.00
IUUC-Hsa-045837	Homo sapiens	96.44	3.00e-110	390.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.15	9.00e-120	422.00
IUUC-Lch-049965	Latimeria chalumnae	79.39	4.00e-99	353.00
IUUC-Laf-053353	Loxodonta africana	95.11	9.00e-100	355.00
IUUC-Mcc-055155	Macaca mulatta	96.55	3.00e-72	263.00
IUUC-Meu-056470	Macropus eugenii	92.13	1.00e-110	392.00
IUUC-Mga-059570	Meleagris gallopavo	87.89	2.00e-90	324.00
IUUC-Mmr-061385	Microcebus murinus	96.80	1.00e-110	392.00
IUUC-Mdo-062144	Monodelphis domestica	92.58	2.00e-112	398.00
IUUC-Mpu-065749	Mustela putorius furo	96.23	9.00e-99	352.00
IUUC-Nle-069968	Nomascus leucogenys	96.32	6.00e-81	293.00
IUUC-Ont-071524	Oreochromis niloticus	65.20	2.00e-86	312.00
IUUC-Ocu-074870	Oryctolagus cuniculus	97.43	5.00e-120	423.00
IUUC-Oga-088336	Otolemur garnettii	96.69	3.00e-110	391.00
IUUC-Oar-090136	Ovis aries	97.41	6.00e-119	420.00
IUUC-Ptr-091348	Pan troglodytes	96.84	1.00e-81	296.00
IUUC-Pan-092819	Papio anubis	96.44	3.00e-110	390.00
IUUC-Pfo-096633	Poecilia formosa	65.57	3.00e-80	291.00
IUUC-Pab-098346	Pongo abelii	96.09	9.00e-110	389.00
IUUC-Pca-100278	Procavia capensis	94.09	7.00e-116	409.00
IUUC-Pva-103190	Pteropus vampyrus	97.73	1.00e-115	409.00
IUUC-Rno-104940	Rattus norvegicus	98.48	2.00e-116	411.00
IUUC-Sha-107533	Sarcophilus harrisii	90.81	3.00e-113	401.00
IUUC-Sar-113630	Sorex araneus	94.63	2.00e-89	321.00
IUUC-Ssc-115734	Sus scrofa	97.73	1.00e-115	409.00
IUUC-Tgu-117034	Taeniopygia guttata	87.56	7.00e-91	326.00
IUUC-Tru-118168	Takifugu rubripes	60.22	7.00e-80	290.00
IUUC-Tsy-119494	Tarsius syrichta	97.37	4.00e-82	297.00
IUUC-Tni-120100	Tetraodon nigroviridis	62.75	7.00e-78	283.00
IUUC-Ttr-128442	Tursiops truncatus	98.05	2.00e-91	328.00
IUUC-Vpa-130063	Vicugna pacos	96.09	2.00e-118	418.00
IUUC-Xtr-132348	Xenopus tropicalis	70.11	9.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence