iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048303

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTP01045339

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000013723.2	ENSSTOT00000013772.2	ENSSTOP00000012342.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.20e-32	111.0	1038	1089

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
           +C+vC +++++e+ +++C++C++w+H+ C +l+ eee++n  +  + C+ Cr
   Q: 1038 SCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADigFDCSMCR 1089
           6********************************999999998899******8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MSLFLSRPRS RGKTTVDDED SMDGLETTEA ENIVETEVKE QSAEEDAEAE VDSSKQPASA 60
LQRSMSEDSA NSLVSVGVEA KISEQLCAFC YCGEKSSLGQ GDLKQFRVTP GFILPWKNQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCTACTCT GTCCAGAACC TATTAAGTTG TTGAAGCTAC TCCTGTAGAC AAAGGGAGTC 60
TCCAGAAGGT TATCTGGAAA GAGGAAAGGC CAGAATAGGG ATACCTCGGC CAGTTTTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	85.18	0.00e+00	7060.00
IUUC-Apl-003311	Anas platyrhynchos	71.71	0.00e+00	5721.00
IUUC-Aca-004705	Anolis carolinensis	66.14	0.00e+00	5330.00
IUUC-Bta-012322	Bos taurus	81.82	0.00e+00	6626.00
IUUC-Cel-018354	Caenorhabditis elegans	35.67	1.00e-64	243.00
IUUC-Cja-019983	Callithrix jacchus	86.92	0.00e+00	7434.00
IUUC-Cfa-020903	Canis familiaris	84.29	0.00e+00	7180.00
IUUC-Cpo-021732	Cavia porcellus	84.11	0.00e+00	7107.00
IUUC-Csa-023083	Chlorocebus sabaeus	85.14	0.00e+00	5522.00
IUUC-Cho-024469	Choloepus hoffmanni	79.37	0.00e+00	2195.00
IUUC-Dre-028110	Danio rerio	63.89	0.00e+00	1247.00
IUUC-Dor-030569	Dipodomys ordii	81.38	0.00e+00	4611.00
IUUC-Dme-031590	Drosophila melanogaster	33.60	2.00e-69	258.00
IUUC-Eca-033945	Equus caballus	84.96	0.00e+00	5153.00
IUUC-Fca-035922	Felis catus	83.58	0.00e+00	6879.00
IUUC-Gac-041896	Gasterosteus aculeatus	48.75	0.00e+00	1357.00
IUUC-Ggo-044812	Gorilla gorilla	84.90	0.00e+00	7228.00
IUUC-Hsa-046595	Homo sapiens	87.45	0.00e+00	7454.00
IUUC-Lch-050086	Latimeria chalumnae	56.73	0.00e+00	2642.00
IUUC-Loc-052891	Lepisosteus oculatus	50.33	0.00e+00	2085.00
IUUC-Laf-054348	Loxodonta africana	81.50	0.00e+00	3027.00
IUUC-Mcc-054868	Macaca mulatta	87.59	0.00e+00	7393.00
IUUC-Meu-056322	Macropus eugenii	66.81	0.00e+00	1202.00
IUUC-Mga-059541	Meleagris gallopavo	71.50	0.00e+00	5638.00
IUUC-Mmr-061092	Microcebus murinus	84.79	0.00e+00	5534.00
IUUC-Mdo-062610	Monodelphis domestica	74.78	0.00e+00	2075.00
IUUC-Mmu-063666	Mus musculus	84.88	0.00e+00	7105.00
IUUC-Mpu-066366	Mustela putorius furo	83.14	0.00e+00	6555.00
IUUC-Mlu-068201	Myotis lucifugus	80.87	0.00e+00	4162.00
IUUC-Nle-069232	Nomascus leucogenys	84.61	0.00e+00	5486.00
IUUC-Opr-070625	Ochotona princeps	76.25	0.00e+00	1307.00
IUUC-Ont-072401	Oreochromis niloticus	56.76	0.00e+00	1050.00
IUUC-Oan-072945	Ornithorhynchus anatinus	71.16	0.00e+00	4186.00
IUUC-Ocu-074920	Oryctolagus cuniculus	82.47	0.00e+00	5361.00
IUUC-Ola-086436	Oryzias latipes	43.98	0.00e+00	1831.00
IUUC-Oga-088637	Otolemur garnettii	82.20	0.00e+00	4352.00
IUUC-Oar-089363	Ovis aries	79.78	0.00e+00	6465.00
IUUC-Ptr-091527	Pan troglodytes	87.49	0.00e+00	7510.00
IUUC-Pan-092102	Papio anubis	85.05	0.00e+00	7105.00
IUUC-Pma-094252	Petromyzon marinus	39.07	0.00e+00	635.00
IUUC-Pfo-096288	Poecilia formosa	47.63	0.00e+00	1472.00
IUUC-Pab-098241	Pongo abelii	86.58	0.00e+00	4778.00
IUUC-Pca-100103	Procavia capensis	79.86	0.00e+00	1562.00
IUUC-Pva-102238	Pteropus vampyrus	76.23	0.00e+00	2562.00
IUUC-Rno-105395	Rattus norvegicus	75.44	0.00e+00	1128.00
IUUC-Sha-106550	Sarcophilus harrisii	71.98	0.00e+00	4430.00
IUUC-Sar-113183	Sorex araneus	65.78	0.00e+00	682.00
IUUC-Tgu-116677	Taeniopygia guttata	71.12	0.00e+00	5390.00
IUUC-Tru-118037	Takifugu rubripes	47.30	0.00e+00	1463.00
IUUC-Tsy-118932	Tarsius syrichta	86.29	0.00e+00	5270.00
IUUC-Tni-119970	Tetraodon nigroviridis	47.21	0.00e+00	1405.00
IUUC-Ttr-129051	Tursiops truncatus	82.66	0.00e+00	6584.00
IUUC-Vpa-130236	Vicugna pacos	80.50	0.00e+00	1889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence