iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091527

Ensembl Protein ID

ENSPTRP00000046674.3

UniProt Accession

H2R471; H2R471_PANTR

Genbank Protein ID

ENSPTRP00000046674

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AACZ02089365

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000019892.5	ENSPTRT00000043948.3	ENSPTRP00000046674.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.20e-30	103.4	1033	1084

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
           +C+vC +++++e+ +++C++C++w+H+ C +l+ eee++n  +  + C+ Cr
   Q: 1033 SCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADigFDCSMCR 1084
           6********************************999999998899******8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

RPRSRGKTAV EDEDSMDGLE TTETETIVET EIKEQSAEED AEAEVDNSKQ LIPTLQRSVS 60
EESANSLVSV GVEAKISEQL CAFCYCGEKS SLGQGDLKQF RITPGFILPW RNQPSNKKDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGCCCTTC CCCTTTCCAC GAGGCCAGTT CCTACTTTTT CTTCTGCTCT TGCTTTAGAC 60
CTCTGCCCTC CGTGAGAATG GCTGTGTCCC CCTAAATGCT TCTGCCAACC TTGTGCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	88.11	0.00e+00	7351.00
IUUC-Apl-003311	Anas platyrhynchos	73.22	0.00e+00	5841.00
IUUC-Aca-004705	Anolis carolinensis	66.75	0.00e+00	5352.00
IUUC-Bta-012322	Bos taurus	83.59	0.00e+00	6808.00
IUUC-Cel-018354	Caenorhabditis elegans	35.38	8.00e-65	243.00
IUUC-Cja-019983	Callithrix jacchus	95.62	0.00e+00	8170.00
IUUC-Cfa-020903	Canis familiaris	87.60	0.00e+00	7413.00
IUUC-Cpo-021732	Cavia porcellus	83.74	0.00e+00	7047.00
IUUC-Csa-023083	Chlorocebus sabaeus	96.67	0.00e+00	6376.00
IUUC-Cho-024469	Choloepus hoffmanni	84.03	0.00e+00	2331.00
IUUC-Dre-028110	Danio rerio	63.89	0.00e+00	1243.00
IUUC-Dor-030569	Dipodomys ordii	81.19	0.00e+00	4590.00
IUUC-Dme-031590	Drosophila melanogaster	33.01	2.00e-69	258.00
IUUC-Eca-033945	Equus caballus	87.78	0.00e+00	5256.00
IUUC-Fca-035922	Felis catus	85.67	0.00e+00	7064.00
IUUC-Gmo-038719	Gadus morhua	72.94	0.00e+00	815.00
IUUC-Gac-041896	Gasterosteus aculeatus	46.10	0.00e+00	1852.00
IUUC-Ggo-044812	Gorilla gorilla	96.19	0.00e+00	8234.00
IUUC-Hsa-046595	Homo sapiens	99.22	0.00e+00	8513.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	87.43	0.00e+00	7207.00
IUUC-Lch-050086	Latimeria chalumnae	57.54	0.00e+00	2706.00
IUUC-Loc-052891	Lepisosteus oculatus	51.25	0.00e+00	2095.00
IUUC-Laf-054348	Loxodonta africana	84.51	0.00e+00	3160.00
IUUC-Mcc-054868	Macaca mulatta	97.16	0.00e+00	8275.00
IUUC-Meu-056322	Macropus eugenii	68.06	0.00e+00	1221.00
IUUC-Mga-059541	Meleagris gallopavo	72.65	0.00e+00	5735.00
IUUC-Mmr-061092	Microcebus murinus	88.96	0.00e+00	5836.00
IUUC-Mdo-062610	Monodelphis domestica	76.62	0.00e+00	2085.00
IUUC-Mmu-063666	Mus musculus	84.83	0.00e+00	7059.00
IUUC-Mpu-066366	Mustela putorius furo	85.09	0.00e+00	6728.00
IUUC-Mlu-068201	Myotis lucifugus	82.73	0.00e+00	4216.00
IUUC-Nle-069232	Nomascus leucogenys	96.89	0.00e+00	6372.00
IUUC-Opr-070625	Ochotona princeps	77.40	0.00e+00	1352.00
IUUC-Ont-072401	Oreochromis niloticus	56.96	0.00e+00	1052.00
IUUC-Oan-072945	Ornithorhynchus anatinus	72.43	0.00e+00	4268.00
IUUC-Ocu-074920	Oryctolagus cuniculus	85.12	0.00e+00	5480.00
IUUC-Ola-086436	Oryzias latipes	44.80	0.00e+00	1835.00
IUUC-Oga-088637	Otolemur garnettii	86.64	0.00e+00	4611.00
IUUC-Oar-089363	Ovis aries	81.81	0.00e+00	6639.00
IUUC-Pan-092102	Papio anubis	94.73	0.00e+00	7971.00
IUUC-Pma-094252	Petromyzon marinus	45.31	2.00e-164	574.00
IUUC-Pfo-096288	Poecilia formosa	60.98	0.00e+00	1164.00
IUUC-Pab-098241	Pongo abelii	97.80	0.00e+00	5460.00
IUUC-Pca-100103	Procavia capensis	81.06	0.00e+00	1590.00
IUUC-Pva-102238	Pteropus vampyrus	77.77	0.00e+00	2636.00
IUUC-Rno-105395	Rattus norvegicus	75.71	0.00e+00	1115.00
IUUC-Sha-106550	Sarcophilus harrisii	73.52	0.00e+00	4510.00
IUUC-Sar-113183	Sorex araneus	65.72	0.00e+00	680.00
IUUC-Tgu-116677	Taeniopygia guttata	71.73	0.00e+00	5503.00
IUUC-Tru-118037	Takifugu rubripes	53.81	0.00e+00	1273.00
IUUC-Tsy-118932	Tarsius syrichta	90.90	0.00e+00	5572.00
IUUC-Tni-119970	Tetraodon nigroviridis	52.50	0.00e+00	1342.00
IUUC-Ttr-129051	Tursiops truncatus	84.67	0.00e+00	6814.00
IUUC-Vpa-130236	Vicugna pacos	83.67	0.00e+00	1963.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence