iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20352094

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.70e-08	33.3	22	63

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++++ p+vlpC H+f++ Clq++  ++  +s + +CP+Cr
   Q: 22   CSICLDRYRC-PKVLPCLHTFCERCLQNY-IPP--QSLTLSCPVCR 63
           ********99.******************.555..9999******8 PP

Organism

Rattus norvegicus

Functional Description
(View)

Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B.

Protein Sequence
(Fasta)

MAKREDSPGP EVQPMDKQFL VCSICLDRYR CPKVLPCLHT FCERCLQNYI PPQSLTLSCP 60
VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSAVAG RPLSCPNHEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGGCGG CGCCGGCGCG GGGACAGACG GAGGCGCGGG ACGTGGGGCG GCGCCGCGGG 60
CAGGGCCGGG CGGACGAGCG CTGGCAGCGG GGGCAGCGCT GCGGGCCGCT CCGAGTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0005794--C:Golgi apparatus
GO:0008270--F:zinc ion binding
GO:0015031--P:protein transport

KEGG

rno:83616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001769	Ailuropoda melanoleuca	98.66	0.00e+00	1487.00
IUUC-Bta-013091	Bos taurus	98.92	0.00e+00	1516.00
IUUC-Cja-019116	Callithrix jacchus	98.79	0.00e+00	1512.00
IUUC-Cfa-020946	Canis familiaris	98.92	0.00e+00	1514.00
IUUC-Cpo-021747	Cavia porcellus	99.33	0.00e+00	1519.00
IUUC-Csa-023901	Chlorocebus sabaeus	98.66	0.00e+00	1510.00
IUUC-Csv-026112	Ciona savignyi	27.51	2.00e-79	290.00
IUUC-Dre-028509	Danio rerio	73.51	0.00e+00	1157.00
IUUC-Dno-029414	Dasypus novemcinctus	98.92	0.00e+00	1516.00
IUUC-Ete-032776	Echinops telfairi	97.58	0.00e+00	1486.00
IUUC-Eca-034308	Equus caballus	98.92	0.00e+00	1512.00
IUUC-Eeu-034845	Erinaceus europaeus	90.99	0.00e+00	1367.00
IUUC-Fca-035594	Felis catus	98.92	0.00e+00	1516.00
IUUC-Gga-040515	Gallus gallus	79.49	0.00e+00	1233.00
IUUC-Gac-042506	Gasterosteus aculeatus	74.83	0.00e+00	1135.00
IUUC-Gma-044219	Glycine max	37.50	2.00e-07	51.60
IUUC-Ggo-045603	Gorilla gorilla	98.92	0.00e+00	1512.00
IUUC-Hsa-046416	Homo sapiens	98.79	0.00e+00	1513.00
IUUC-Itr-048448	Ictidomys tridecemlineatus	98.79	0.00e+00	1512.00
IUUC-Lch-050005	Latimeria chalumnae	69.15	0.00e+00	1103.00
IUUC-Loc-052433	Lepisosteus oculatus	74.77	0.00e+00	1185.00
IUUC-Laf-053930	Loxodonta africana	98.25	0.00e+00	1505.00
IUUC-Mcc-055778	Macaca mulatta	98.66	0.00e+00	1509.00
IUUC-Meu-056100	Macropus eugenii	91.57	0.00e+00	1316.00
IUUC-Mmr-060733	Microcebus murinus	98.92	0.00e+00	1514.00
IUUC-Mdo-062705	Monodelphis domestica	90.99	0.00e+00	1402.00
IUUC-Mmu-063965	Mus musculus	99.87	0.00e+00	1530.00
IUUC-Mpu-066757	Mustela putorius furo	99.06	0.00e+00	1516.00
IUUC-Mlu-067822	Myotis lucifugus	87.04	0.00e+00	1145.00
IUUC-Nle-069595	Nomascus leucogenys	98.44	0.00e+00	1422.00
IUUC-Ont-071250	Oreochromis niloticus	76.27	0.00e+00	1161.00
IUUC-Ocu-074675	Oryctolagus cuniculus	98.92	0.00e+00	1510.00
IUUC-Ola-087179	Oryzias latipes	75.20	0.00e+00	1146.00
IUUC-Oga-089121	Otolemur garnettii	99.06	0.00e+00	1516.00
IUUC-Oar-089931	Ovis aries	95.70	0.00e+00	1438.00
IUUC-Ptr-090907	Pan troglodytes	98.79	0.00e+00	1513.00
IUUC-Pan-092076	Papio anubis	98.66	0.00e+00	1509.00
IUUC-Pfo-097324	Poecilia formosa	72.77	0.00e+00	1131.00
IUUC-Pab-097602	Pongo abelii	94.49	0.00e+00	1425.00
IUUC-Pva-103232	Pteropus vampyrus	98.79	0.00e+00	1484.00
IUUC-Sha-107604	Sarcophilus harrisii	91.26	0.00e+00	1405.00
IUUC-Stu-112510	Solanum tuberosum	37.50	1.00e-08	53.10
IUUC-Sar-113243	Sorex araneus	98.01	0.00e+00	894.00
IUUC-Ssc-115253	Sus scrofa	91.26	0.00e+00	1378.00
IUUC-Tru-118267	Takifugu rubripes	74.37	0.00e+00	1163.00
IUUC-Tsy-119487	Tarsius syrichta	99.22	0.00e+00	1036.00
IUUC-Tni-120733	Tetraodon nigroviridis	74.97	0.00e+00	1154.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence