iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053805

UUCD1 version

UUC-LoA-00877

Ensembl Protein ID

ENSLAFP00000028180.1

UniProt Accession

G3UK21; G3UK21_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TRIM6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005775.3	ENSLAFT00000030832.1	ENSLAFP00000028180.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.80e-07	31.4	9	80
E3 activity/RING/RING	2.80e-09	37.7	15	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk........tcPvtrqplteedlvPnltlrrliqa 67
           + +e  CpI lel ++P+ l +G+++ +++I      +++        +cPv+r++ ++ +l Pn  l +++++
   Q: 9    IRDEVTCPICLELLTEPMSLDCGHSFCQACITGNS--KQSeisqeggsSCPVCRTSYQPGNLRPNRHLANIVER 80
           668999*************************8854..22234566666******************99888765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           C+iCle + + p++l+CgH f++ C+  +  +++  s+ +  +CP+Cr
   Q: 15   CPICLELLTE-PMSLDCGHSFCQACItgNS-KQSEISQEGGSSCPVCR 60
           ********99.***************8544.489999**********8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MTSAVLVDIR DEVTCPICLE LLTEPMSLDC GHSFCQACIT GNSKQSEISQ EGGSSCPVCR 60
TSYQPGNLRP NRHLANIVER LREAVLGPEK QLKVILCTDH GEKLQLFCKE DGKIICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTTCAG CAGTACTAGT GGACATACGA GATGAAGTGA CCTGCCCCAT CTGCCTGGAG 60
CTCTTGACGG AACCCATGAG CCTAGACTGT GGGCACAGCT TCTGCCAAGC CTGCATCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	77.25	0.00e+00	750.00
IUUC-Bta-013110	Bos taurus	53.52	6.00e-148	517.00
IUUC-Cho-024416	Choloepus hoffmanni	64.59	1.00e-96	347.00
IUUC-Dno-029492	Dasypus novemcinctus	53.35	3.00e-147	515.00
IUUC-Dor-030700	Dipodomys ordii	46.75	3.00e-120	425.00
IUUC-Fca-035533	Felis catus	78.89	0.00e+00	768.00
IUUC-Hsa-046006	Homo sapiens	79.51	0.00e+00	796.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	76.55	0.00e+00	734.00
IUUC-Mmr-061023	Microcebus murinus	77.48	0.00e+00	735.00
IUUC-Mmu-063682	Mus musculus	76.64	0.00e+00	760.00
IUUC-Mpu-065842	Mustela putorius furo	77.57	0.00e+00	749.00
IUUC-Oga-088267	Otolemur garnettii	77.16	0.00e+00	750.00
IUUC-Ptr-090573	Pan troglodytes	80.12	0.00e+00	802.00
IUUC-Pan-092745	Papio anubis	79.92	0.00e+00	790.00
IUUC-Pma-094336	Petromyzon marinus	35.00	5.00e-19	86.30

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence