iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062613

UUCD1 version

UUC-MoD-01085

Ensembl Protein ID

ENSMODP00000035827.1

UniProt Accession

F7F9B0; F7F9B0_MONDO

Protein Name

Ubiquitin thioesterase

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000024840.1	ENSMODT00000037412.1	ENSMODP00000035827.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.20e-44	152.2	82	272

Active Site

Position(s)	Description	Evidence
89	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
92	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
266		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll  f+d+ +sd
   Q: 82   YIRKTRPDGNCFYRAFGFSylealledskelqrfkaisakskedlvsqgfiefaiedfhntlmdlieqvekqtsvdeLLTAFNDQNISD 170
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv +Lr+lts ylq+es+ff+ fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d+ e   g  ++ ++fpe + +
   Q: 171  YLVAYLRLLTSGYLQRESEFFEFFIEGGRTVKEFCQQEVEPMSKeSDHIHIIALAQALSISIQVEYMDRAE---GRSTNSHVFPEGS-E 255
           **********************************************************************9...899**********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 256  PKVYLLYRPGHYDILYK 272
           ***************96 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

KMAAEKPQQQ NSEPLGNDSE EVNGLAYDGA IMAQEDQIQQ EIALQNPLVS ERLELSVLYK 60
EYVGDDNIYQ EKIKDLHKKY SYIRKTRPDG NCFYRAFGFS YLEALLEDSK ELQRFKAISA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATGGCGG CAGAGAAACC TCAGCAGCAG AACTCTGAGC CTCTGGGAAA TGACTCTGAA 60
GAAGTTAACG GTTTGGCCTA TGATGGAGCC ATTATGGCCC AGGAGGATCA AATTCAGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	85.04	2.00e-130	457.00
IUUC-Apl-003233	Anas platyrhynchos	56.92	2.00e-12	63.20
IUUC-Aca-004648	Anolis carolinensis	76.64	5.00e-116	410.00
IUUC-Aly-005710	Arabidopsis lyrata	42.75	4.00e-47	181.00
IUUC-Ath-007112	Arabidopsis thaliana	42.70	1.00e-47	183.00
IUUC-Afl-008439	Aspergillus flavus	32.91	4.00e-08	51.60
IUUC-Ame-010662	Astyanax mexicanus	75.85	2.00e-113	401.00
IUUC-Bta-013533	Bos taurus	86.72	5.00e-128	450.00
IUUC-Bol-016100	Brassica oleracea	39.66	1.00e-47	183.00
IUUC-Bra-017705	Brassica rapa	36.13	3.00e-40	159.00
IUUC-Cel-018295	Caenorhabditis elegans	32.49	2.00e-38	152.00
IUUC-Cja-019190	Callithrix jacchus	87.13	1.00e-129	455.00
IUUC-Cfa-020430	Canis familiaris	88.05	3.00e-125	441.00
IUUC-Cpo-022355	Cavia porcellus	87.45	3.00e-129	454.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.89	1.00e-43	169.00
IUUC-Csa-023286	Chlorocebus sabaeus	84.29	1.00e-126	445.00
IUUC-Cin-025507	Ciona intestinalis	41.67	8.00e-39	152.00
IUUC-Csv-026273	Ciona savignyi	46.51	1.00e-62	233.00
IUUC-Dre-027843	Danio rerio	73.98	4.00e-112	397.00
IUUC-Dno-029165	Dasypus novemcinctus	88.00	1.00e-99	355.00
IUUC-Dor-030943	Dipodomys ordii	87.45	3.00e-129	454.00
IUUC-Dme-031922	Drosophila melanogaster	54.80	7.00e-72	263.00
IUUC-Ete-032296	Echinops telfairi	84.91	4.00e-73	267.00
IUUC-Eca-033695	Equus caballus	87.25	2.00e-124	438.00
IUUC-Fca-036441	Felis catus	88.05	2.00e-125	441.00
IUUC-Gmo-038908	Gadus morhua	74.26	2.00e-112	398.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.85	3.00e-30	127.00
IUUC-Gga-040460	Gallus gallus	75.65	6.00e-117	413.00
IUUC-Gac-042417	Gasterosteus aculeatus	75.60	3.00e-109	387.00
IUUC-Gma-043712	Glycine max	42.09	3.00e-47	182.00
IUUC-Ggo-044552	Gorilla gorilla	87.42	1.00e-75	276.00
IUUC-Hsa-046766	Homo sapiens	87.08	5.00e-129	453.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	87.45	3.00e-129	454.00
IUUC-Lch-050602	Latimeria chalumnae	76.89	9.00e-105	372.00
IUUC-Laf-053705	Loxodonta africana	87.45	3.00e-129	454.00
IUUC-Mcc-055745	Macaca mulatta	81.66	1.00e-125	442.00
IUUC-Meu-056569	Macropus eugenii	77.49	4.00e-114	404.00
IUUC-Mtr-057712	Medicago truncatula	43.87	5.00e-44	171.00
IUUC-Mvi-060358	Microbotryum violaceum	32.10	2.00e-14	72.80
IUUC-Mmr-061123	Microcebus murinus	86.64	6.00e-106	376.00
IUUC-Mmu-063658	Mus musculus	87.45	3.00e-129	454.00
IUUC-Mac-065274	Musa acuminata	38.00	8.00e-36	144.00
IUUC-Mpu-066172	Mustela putorius furo	87.08	5.00e-129	453.00
IUUC-Mlu-066966	Myotis lucifugus	86.40	9.00e-129	452.00
IUUC-Nle-069519	Nomascus leucogenys	86.34	4.00e-76	278.00
IUUC-Ont-071901	Oreochromis niloticus	76.49	4.00e-111	394.00
IUUC-Ola-087331	Oryzias latipes	77.53	2.00e-78	285.00
IUUC-Oga-088064	Otolemur garnettii	87.08	5.00e-129	453.00
IUUC-Oar-089251	Ovis aries	87.35	8.00e-125	439.00
IUUC-Ptr-091430	Pan troglodytes	87.13	9.00e-130	456.00
IUUC-Psi-093823	Pelodiscus sinensis	81.89	8.00e-114	402.00
IUUC-Pma-094366	Petromyzon marinus	66.54	8.00e-90	323.00
IUUC-Pfo-096734	Poecilia formosa	75.30	2.00e-100	358.00
IUUC-Pab-097919	Pongo abelii	87.07	7.00e-106	376.00
IUUC-Pop-099401	Populus trichocarpa	40.00	1.00e-44	172.00
IUUC-Ppe-101977	Prunus persica	43.49	8.00e-49	187.00
IUUC-Pva-102499	Pteropus vampyrus	88.05	1.00e-125	441.00
IUUC-Rno-105233	Rattus norvegicus	87.45	3.00e-129	454.00
IUUC-Sha-107081	Sarcophilus harrisii	88.84	8.00e-126	442.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	2.00e-46	179.00
IUUC-Ssc-116202	Sus scrofa	87.08	5.00e-129	453.00
IUUC-Tru-117664	Takifugu rubripes	70.76	3.00e-107	380.00
IUUC-Tca-121467	Theobroma cacao	42.65	2.00e-47	182.00
IUUC-Tbe-128116	Tupaia belangeri	86.34	4.00e-76	277.00
IUUC-Ttr-128622	Tursiops truncatus	86.35	2.00e-126	444.00
IUUC-Vvi-131389	Vitis vinifera	44.12	1.00e-48	186.00
IUUC-Xma-134191	Xiphophorus maculatus	75.30	4.00e-101	360.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence