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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105969
UUCD1 version UUC-RaN-00949
Ensembl Protein ID ENSRNOP00000009969.2
UniProt Accession Q9ER30; KLH41_RAT
Genbank Protein ID CAC08185.1
Protein Name Kelch-like protein 41; Kel-like protein 23; Kelch repeat and BTB domain-containing protein 10; Kelch-related protein 1; Sarcosin
Genbank Nucleotide ID AJ293948
Gene Name Klhl41; Kbtbd10; Krp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007461.3 ENSRNOT00000009969.3 ENSRNOP00000009969.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.00e-17 63.7 34 100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 2.30e-10 39.6 132 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           D++l+ g++ f++h+++L+a+S++F+  fl+e ee k k+++ ++ v+p  +  ++k+lY+ ++d+n+
   Q: 34   DCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEK-KKEMALDNVDPAILDLIIKYLYSASIDLND 100
           9*********************************999.9999***********************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           + Ncl+ilr++ l+dcp+L+ +a++f+++ F
   Q: 132  PGNCLAILRLGLLLDCPRLAISAREFVSDRF 162
           56***************************99 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
 Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
Protein Sequence
(Fasta)
MDSQRELAEE LRLYQSTLLQ DGLKDLLEEK KFIDCTLKAG DKSFPCHRLI LSACSPYFRE 60
YFLSEIEEEK KKEMALDNVD PAILDLIIKY LYSASIDLND GNVQDIFALS SRFQIPSVFT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105969|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGATTCCC AGCGGGAGCT TGCAGAGGAA CTCCGGCTTT ACCAATCCAC CCTTCTTCAG 60
GATGGTCTAA AAGATCTCCT GGAAGAGAAA AAATTCATCG ATTGTACCCT AAAAGCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105969|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0880--Kelch repeat
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0703--Sarcoplasmic reticulum
KW-0832--Ubl conjugation
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030571--KLHL41
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0031430--C:M band
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031143--C:pseudopodium
GO:0001726--C:ruffle
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0030239--P:myofibril assembly
GO:0016567--P:protein ubiquitination
GO:0031275--P:regulation of lateral pseudopodium assembly
GO:0045661--P:regulation of myoblast differentiation
GO:2000291--P:regulation of myoblast proliferation
GO:2001014--P:regulation of skeletal muscle cell differentiation
GO:0045214--P:sarcomere organization
GO:0035914--P:skeletal muscle cell differentiation
GO:0048741--P:skeletal muscle fiber development
KEGG rno:117537
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002167 Ailuropoda melanoleuca 95.38 0.00e+00 1150.00
IUUC-Apl-003866 Anas platyrhynchos 85.15 0.00e+00 1019.00
IUUC-Ame-011172 Astyanax mexicanus 61.19 0.00e+00 749.00
IUUC-Bta-012925 Bos taurus 95.38 0.00e+00 1149.00
IUUC-Bci-013875 Botrytis cinerea 27.96 4.00e-17 82.00
IUUC-Cja-019348 Callithrix jacchus 94.72 0.00e+00 1145.00
IUUC-Cfa-020782 Canis familiaris 95.87 0.00e+00 1154.00
IUUC-Cpo-021825 Cavia porcellus 93.73 0.00e+00 1131.00
IUUC-Csa-023184 Chlorocebus sabaeus 94.43 0.00e+00 975.00
IUUC-Cin-025237 Ciona intestinalis 29.57 1.00e-67 250.00
IUUC-Dre-028278 Danio rerio 60.26 0.00e+00 766.00
IUUC-Dno-029516 Dasypus novemcinctus 94.72 0.00e+00 1140.00
IUUC-Dor-030850 Dipodomys ordii 94.47 0.00e+00 770.00
IUUC-Ete-032697 Echinops telfairi 92.41 0.00e+00 1098.00
IUUC-Eca-033714 Equus caballus 95.87 0.00e+00 1153.00
IUUC-Eeu-035245 Erinaceus europaeus 93.32 0.00e+00 1054.00
IUUC-Gmo-039392 Gadus morhua 57.96 0.00e+00 734.00
IUUC-Ggr-040041 Gaeumannomyces graminis 28.47 6.00e-08 51.60
IUUC-Gga-041106 Gallus gallus 84.65 0.00e+00 1033.00
IUUC-Gac-042252 Gasterosteus aculeatus 60.53 0.00e+00 763.00
IUUC-Ggo-044817 Gorilla gorilla 95.21 0.00e+00 1146.00
IUUC-Hsa-046620 Homo sapiens 95.21 0.00e+00 1145.00
IUUC-Lch-050477 Latimeria chalumnae 69.47 0.00e+00 847.00
IUUC-Loc-051955 Lepisosteus oculatus 69.47 0.00e+00 896.00
IUUC-Laf-053500 Loxodonta africana 95.38 0.00e+00 1144.00
IUUC-Mcc-055316 Macaca mulatta 95.05 0.00e+00 1146.00
IUUC-Mmr-061444 Microcebus murinus 95.38 0.00e+00 1149.00
IUUC-Mmu-064147 Mus musculus 98.84 0.00e+00 1180.00
IUUC-Mlu-067481 Myotis lucifugus 93.07 0.00e+00 1125.00
IUUC-Nle-069339 Nomascus leucogenys 95.38 0.00e+00 1147.00
IUUC-Opr-070703 Ochotona princeps 94.88 0.00e+00 1102.00
IUUC-Ont-072420 Oreochromis niloticus 60.30 0.00e+00 784.00
IUUC-Oan-073476 Ornithorhynchus anatinus 92.90 0.00e+00 1123.00
IUUC-Ocu-074248 Oryctolagus cuniculus 95.05 0.00e+00 1152.00
IUUC-Ola-086361 Oryzias latipes 62.17 0.00e+00 771.00
IUUC-Oar-090349 Ovis aries 94.88 0.00e+00 1145.00
IUUC-Pan-092069 Papio anubis 95.21 0.00e+00 1147.00
IUUC-Psi-093671 Pelodiscus sinensis 87.13 0.00e+00 1026.00
IUUC-Pfo-096122 Poecilia formosa 61.96 0.00e+00 798.00
IUUC-Pab-098711 Pongo abelii 95.05 0.00e+00 1145.00
IUUC-Pca-100495 Procavia capensis 86.80 0.00e+00 1023.00
IUUC-Pva-102401 Pteropus vampyrus 95.38 0.00e+00 1150.00
IUUC-Sar-113405 Sorex araneus 92.74 0.00e+00 1112.00
IUUC-Tgu-116725 Taeniopygia guttata 85.31 0.00e+00 1054.00
IUUC-Tru-117743 Takifugu rubripes 59.20 0.00e+00 753.00
IUUC-Tsy-119225 Tarsius syrichta 89.11 0.00e+00 1053.00
IUUC-Tni-120547 Tetraodon nigroviridis 61.79 0.00e+00 778.00
IUUC-Ttr-128645 Tursiops truncatus 95.05 0.00e+00 1145.00
IUUC-Vpa-130714 Vicugna pacos 95.54 0.00e+00 1151.00
IUUC-Xtr-132144 Xenopus tropicalis 75.91 0.00e+00 934.00
IUUC-Xma-133860 Xiphophorus maculatus 62.13 0.00e+00 801.00
Created Date 25-Jun-2017

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