• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045852
Ensembl Protein ID ENSP00000257749.4
UniProt Accession Q9BYV9; E1P518; Q59H70; Q5T793; Q9NTS5; BACH2_HUMAN
Genbank Protein ID AAK48898.1; CAC28130.1; BAD92126.1; CAI16237.1; CAI16237.1; CAI21648.1; CAI21648.1; EAW48530.1; EAW48531.1; EAW48532.1; EAW48533.1; EAW48534.1
Protein Name Transcription regulator protein BACH2; BTB and CNC homolog 2
Genbank Nucleotide ID AF357835; AJ271878; AB208889; AL353692; AL121787; AL121787; AL353692; CH471051; CH471051; CH471051; CH471051; CH471051
Gene Name BACH2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000112182.14 ENST00000257749.8 ENSP00000257749.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.70e-11 45.9 37 100
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkld 66
           +Dv+l+v+++ef+ah++vLaa+S++F   + ++ ++    l v + + v +  f  ll+F Yt kl 
   Q: 37   CDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKN---DLVVSLPEeVTARGFGPLLQFAYTAKLL 100
           9**************************999776554...589999966****************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
 Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
Protein Sequence
(Fasta)
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 60
YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045852|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCAACAATG TAGCGATTGA GAGTGTGGGC GTTCCGGGGA GAGCGCAAGC CGCGCGGCGC 60
GGAGCAAACA GCGCCGAGCC GCCGCCGCCT CAGCAGCAGC AGCAGCAGCA GCAGCGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045852|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000210--BTB/POZ_dom
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR011333--SKP1/BTB/POZ
IPR008917--TF_DNA-bd
PROSITE

PS50097--BTB
PS50217--BZIP
PS00036--BZIP_BASIC
Pfam

PF00651--BTB
PF03131--bZIP_Maf
SMART

SM00338--BRLZ
SM00225--BTB
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0016567--P:protein ubiquitination
GO:1902593--P:single-organism nuclear import
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:60468
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001451 Ailuropoda melanoleuca 93.58 0.00e+00 1459.00
IUUC-Apl-003617 Anas platyrhynchos 73.29 0.00e+00 1120.00
IUUC-Aca-004829 Anolis carolinensis 76.78 0.00e+00 1174.00
IUUC-Ame-011958 Astyanax mexicanus 51.42 2.00e-180 626.00
IUUC-Bta-013001 Bos taurus 93.36 0.00e+00 1470.00
IUUC-Cja-019232 Callithrix jacchus 97.51 0.00e+00 1498.00
IUUC-Cfa-020872 Canis familiaris 91.54 0.00e+00 1441.00
IUUC-Cpo-022203 Cavia porcellus 78.60 0.00e+00 652.00
IUUC-Csa-023057 Chlorocebus sabaeus 99.17 0.00e+00 1546.00
IUUC-Cho-025090 Choloepus hoffmanni 91.96 0.00e+00 707.00
IUUC-Dre-028449 Danio rerio 57.68 0.00e+00 763.00
IUUC-Dno-029780 Dasypus novemcinctus 93.94 0.00e+00 1434.00
IUUC-Dor-030786 Dipodomys ordii 89.42 0.00e+00 1394.00
IUUC-Eca-033802 Equus caballus 95.01 0.00e+00 1490.00
IUUC-Eeu-035187 Erinaceus europaeus 89.15 0.00e+00 1407.00
IUUC-Fca-036490 Felis catus 83.00 0.00e+00 1293.00
IUUC-Fal-037655 Ficedula albicollis 79.07 0.00e+00 1259.00
IUUC-Gga-041057 Gallus gallus 79.45 0.00e+00 1269.00
IUUC-Gac-041702 Gasterosteus aculeatus 57.82 0.00e+00 768.00
IUUC-Ggo-044982 Gorilla gorilla 99.88 0.00e+00 1526.00
IUUC-Itr-048706 Ictidomys tridecemlineatus 94.48 0.00e+00 1446.00
IUUC-Lch-049448 Latimeria chalumnae 67.50 0.00e+00 1014.00
IUUC-Loc-052840 Lepisosteus oculatus 61.61 0.00e+00 862.00
IUUC-Laf-054135 Loxodonta africana 90.88 0.00e+00 1387.00
IUUC-Mcc-055251 Macaca mulatta 99.64 0.00e+00 1520.00
IUUC-Meu-056518 Macropus eugenii 74.36 0.00e+00 1110.00
IUUC-Mga-060073 Meleagris gallopavo 79.33 0.00e+00 1264.00
IUUC-Mmr-061770 Microcebus murinus 95.60 0.00e+00 1455.00
IUUC-Mdo-062541 Monodelphis domestica 81.46 0.00e+00 1297.00
IUUC-Mmu-063594 Mus musculus 90.12 0.00e+00 1389.00
IUUC-Mpu-066651 Mustela putorius furo 93.94 0.00e+00 1428.00
IUUC-Mlu-067438 Myotis lucifugus 81.15 0.00e+00 1207.00
IUUC-Nle-069208 Nomascus leucogenys 99.52 0.00e+00 1553.00
IUUC-Ont-072358 Oreochromis niloticus 57.38 0.00e+00 768.00
IUUC-Ola-087475 Oryzias latipes 61.84 0.00e+00 740.00
IUUC-Oga-088512 Otolemur garnettii 89.42 0.00e+00 1345.00
IUUC-Oar-090318 Ovis aries 93.59 0.00e+00 1476.00
IUUC-Ptr-091546 Pan troglodytes 96.43 0.00e+00 1449.00
IUUC-Pan-092159 Papio anubis 99.41 0.00e+00 1519.00
IUUC-Psi-093436 Pelodiscus sinensis 80.50 0.00e+00 1283.00
IUUC-Pfo-097497 Poecilia formosa 56.99 0.00e+00 723.00
IUUC-Pab-097676 Pongo abelii 99.52 0.00e+00 1556.00
IUUC-Pca-100624 Procavia capensis 87.80 7.00e-124 438.00
IUUC-Pva-102757 Pteropus vampyrus 90.51 0.00e+00 1399.00
IUUC-Rno-105060 Rattus norvegicus 90.12 0.00e+00 1394.00
IUUC-Sha-107171 Sarcophilus harrisii 81.30 0.00e+00 1236.00
IUUC-Ssc-116190 Sus scrofa 93.29 0.00e+00 1218.00
IUUC-Tgu-116828 Taeniopygia guttata 79.43 0.00e+00 1263.00
IUUC-Tsy-119088 Tarsius syrichta 89.08 0.00e+00 815.00
IUUC-Tbe-127807 Tupaia belangeri 92.80 0.00e+00 1177.00
IUUC-Ttr-128874 Tursiops truncatus 91.34 0.00e+00 1456.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved