iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106402

UUCD1 version

UUC-SaC-00041

Ensembl Protein ID

YNL116W

UniProt Accession

P53924; B0KZS8; B0KZU6; B0KZW4; B0L009; D6W166; Q66GT0; DMA2_YEAST

Genbank Protein ID

ABN58541.1; ABN58550.1; ABN58559.1; ABN58568.1; ABN58576.1; ABN58586.1; ABN58595.1; ABN58604.1; ABN58613.1; ABN58622.1; ABN58631.1; ABN58649.1; CAA93391.1; CAA95996.1; DAA05594.1; DAA10432.1

Protein Name

E3 ubiquitin-protein ligase DMA2; Checkpoint forkhead associated with RING domains-containing protein 1; Defective in mitotic arrest protein 2; RING-type E3 ubiquitin transferase DMA2

Genbank Nucleotide ID

EF125216; EF125217; EF125218; EF125219; EF125220; EF125221; EF125222; EF125223; EF125224; EF125225; EF125226; EF125228; Z69382; Z71392; BK005579; BK006947

Gene Name

DMA2; CHF2; YNL116W; N1925

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YNL116W	YNL116W	YNL116W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18597043

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0014	17.6	433	477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ +  ++  ++ pC H +h+ C+ ++     +s+++f CP Cr
   Q: 433  CSICLCKIkpCQAIFISPCAHSWHFRCVRRL---VMLSYPQFVCPNCR 477
           ******9955333899***********9777...5669*********8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.

Protein Sequence
(Fasta)

MYTPIPANTP APTAPTSSMT SNSSSASNAN TTSSSGINPR NRASGTPSNE RARPASGISS 60
FLNTFGIRQN SQTASSSAAP DQRLFGTTPS NSHMSVAMES IDTAPQQQEP RLHHPIQMPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACACGC CTATCCCTGC TAATACCCCT GCTCCCACTG CACCAACTTC ATCGATGACG 60
TCCAACTCTT CATCCGCATC AAATGCCAAC ACCACTAGCA GTAGTGGCAT AAACCCAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50006--FHA_DOMAIN
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF17123--zf-RING_11

SMART

SM00240--FHA

Gene Ontology

GO:0032177--C:cellular bud neck split septin rings
GO:0005934--C:cellular bud tip
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032186--P:cellular bud neck septin ring organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0031578--P:mitotic spindle orientation checkpoint
GO:0051865--P:protein autoubiquitination
GO:0097271--P:protein localization to bud neck
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090337--P:regulation of formin-nucleated actin cable assembly
GO:0000921--P:septin ring assembly

KEGG

sce:YNL116W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002947	Amborella trichopoda	34.38	1.00e-06	43.90
IUUC-Aca-005036	Anolis carolinensis	36.67	2.00e-07	48.50
IUUC-Ath-006857	Arabidopsis thaliana	33.71	1.00e-07	48.90
IUUC-Ago-007705	Ashbya gossypii	71.54	3.00e-121	426.00
IUUC-Acl-008234	Aspergillus clavatus	46.32	1.00e-53	202.00
IUUC-Afl-008606	Aspergillus flavus	44.44	2.00e-45	175.00
IUUC-Afu-008908	Aspergillus fumigatus	39.21	6.00e-36	143.00
IUUC-Aor-009904	Aspergillus oryzae	46.98	2.00e-50	191.00
IUUC-Ate-010354	Aspergillus terreus	47.81	3.00e-52	197.00
IUUC-Bol-015277	Brassica oleracea	35.16	6.00e-07	46.60
IUUC-Cja-018953	Callithrix jacchus	31.37	8.00e-07	45.80
IUUC-Cpo-022372	Cavia porcellus	32.63	5.00e-07	46.20
IUUC-Cgl-026486	Colletotrichum gloeosporioides	50.65	1.00e-62	231.00
IUUC-Cne-026927	Cryptococcus neoformans	43.33	4.00e-47	181.00
IUUC-Dno-029774	Dasypus novemcinctus	34.83	6.00e-08	50.10
IUUC-Dse-031157	Dothistroma septosporum	47.48	4.00e-59	220.00
IUUC-Eca-033607	Equus caballus	40.35	2.00e-07	48.10
IUUC-Fal-037569	Ficedula albicollis	43.86	6.00e-09	53.50
IUUC-Fox-037681	Fusarium oxysporum	53.39	3.00e-64	237.00
IUUC-Fso-038129	Fusarium solani	43.40	2.00e-50	191.00
IUUC-Gmo-038588	Gadus morhua	35.38	2.00e-05	41.60
IUUC-Ggr-039871	Gaeumannomyces graminis	50.22	7.00e-61	226.00
IUUC-Gga-040777	Gallus gallus	43.86	3.00e-09	54.70
IUUC-Kpa-049298	Komagataella pastoris	59.21	2.00e-73	266.00
IUUC-Lch-049805	Latimeria chalumnae	33.63	2.00e-10	58.50
IUUC-Lpe-050916	Leersia perrieri	42.55	1.00e-06	47.00
IUUC-Loc-051914	Lepisosteus oculatus	31.03	8.00e-07	46.20
IUUC-Lma-053220	Leptosphaeria maculans	47.68	3.00e-55	207.00
IUUC-Mor-057012	Magnaporthe oryzae	51.30	7.00e-65	239.00
IUUC-Mpo-057371	Magnaporthe poae	53.49	8.00e-14	69.70
IUUC-Mla-058879	Melampsora laricipopulina	46.31	1.00e-53	201.00
IUUC-Mga-060049	Meleagris gallopavo	45.61	1.00e-09	55.50
IUUC-Mdo-062016	Monodelphis domestica	34.48	4.00e-08	52.40
IUUC-Mac-065139	Musa acuminata	44.00	9.00e-08	50.10
IUUC-Mlu-068174	Myotis lucifugus	40.98	7.00e-07	47.40
IUUC-Nfi-068378	Neosartorya fischeri	47.62	8.00e-55	206.00
IUUC-Ncr-068692	Neurospora crassa	51.71	3.00e-65	241.00
IUUC-Opr-070300	Ochotona princeps	40.35	7.00e-06	43.10
IUUC-Oan-073250	Ornithorhynchus anatinus	33.33	5.00e-07	43.90
IUUC-Oba-075378	Oryza barthii	38.98	5.00e-07	48.90
IUUC-Ogl-076930	Oryza glaberrima	41.67	7.00e-07	47.00
IUUC-Ogu-078193	Oryza glumaepatula	39.34	3.00e-06	46.60
IUUC-Oin-080046	Oryza indica	43.75	2.00e-07	48.50
IUUC-Oni-082348	Oryza nivara	42.00	3.00e-06	46.60
IUUC-Opu-083145	Oryza punctata	43.75	2.00e-06	46.60
IUUC-Oru-085151	Oryza rufipogon	42.00	3.00e-06	46.60
IUUC-Osa-086063	Oryza sativa	38.98	9.00e-09	53.90
IUUC-Psi-093038	Pelodiscus sinensis	35.96	5.00e-09	53.10
IUUC-Pno-094949	Phaeosphaeria nodorum	43.12	1.00e-31	128.00
IUUC-Pfo-097514	Poecilia formosa	29.73	3.00e-06	44.30
IUUC-Pop-099775	Populus trichocarpa	33.33	3.00e-06	45.10
IUUC-Pca-100201	Procavia capensis	40.98	9.00e-07	47.00
IUUC-Ppe-101276	Prunus persica	38.81	2.00e-07	46.20
IUUC-Ptt-103791	Puccinia triticina	47.45	5.00e-37	146.00
IUUC-Pte-104124	Pyrenophora teres	46.41	1.00e-53	202.00
IUUC-Pyt-104430	Pyrenophora triticirepentis	46.64	9.00e-54	202.00
IUUC-Sha-107202	Sarcophilus harrisii	40.98	8.00e-07	47.40
IUUC-Sja-107979	Schizosaccharomyces japonicus	43.23	8.00e-48	181.00
IUUC-Spo-108168	Schizosaccharomyces pombe	44.98	5.00e-50	189.00
IUUC-Stu-112794	Solanum tuberosum	43.75	8.00e-07	47.00
IUUC-Sre-115012	Sporisorium reilianum	46.70	9.00e-48	183.00
IUUC-Tre-121954	Trichoderma reesei	51.08	2.00e-62	231.00
IUUC-Tvi-122295	Trichoderma virens	51.75	3.00e-64	237.00
IUUC-Tme-126881	Tuber melanosporum	48.50	2.00e-61	228.00
IUUC-Uma-129400	Ustilago maydis	36.24	3.00e-47	181.00
IUUC-Vda-130024	Verticillium dahliae	50.66	1.00e-62	232.00
IUUC-Vpa-130154	Vicugna pacos	33.71	2.00e-07	48.10
IUUC-Vvi-131426	Vitis vinifera	33.33	1.00e-07	47.40
IUUC-Xma-133568	Xiphophorus maculatus	29.73	3.00e-06	44.30
IUUC-Yli-134472	Yarrowia lipolytica	50.00	2.00e-63	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence