iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063767

UUCD1 version

UUC-MuM-00067

Ensembl Protein ID

ENSMUSP00000109336.3

UniProt Accession

Q9ESN2; Q8BPR5; Q8K0F7; TRI39_MOUSE

Genbank Protein ID

BAB16375.1; BAC35409.1; AAH31540.1

Protein Name

E3 ubiquitin-protein ligase TRIM39; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; Testis-abundant finger protein; Tripartite motif-containing protein 39

Genbank Nucleotide ID

AB046382; AK053507; BC031540

Gene Name

Trim39; Rnf23; Tfp

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000045409.16	ENSMUST00000173665.7	ENSMUSP00000133529.1
ENSMUSG00000045409.16	ENSMUST00000113706.9	ENSMUSP00000109336.3
ENSMUSG00000045409.16	ENSMUST00000173369.1	ENSMUSP00000133298.1

Annotation

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.30e-07	32.7	27	87
E3 activity/RING/RING	6.10e-08	34.2	29	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk..tcPvtrqplteedlvPnltlrrl 64
             C++ le  ++Pv++++G+ + +++I +w ++ ++   cPv+r++ + ++l Pn  l ++
   Q: 27   ASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERdfPCPVCRKTSRYRSLRPNRQLGSM 87
           68*****************************88887799****************998766 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle +k+ p++  CgH f++ C+ +w        + f CP+Cr
   Q: 29   CSVCLEYLKE-PVIIECGHNFCKACITRW---WEDLERDFPCPVCR 70
           ********99.999************999...666889999****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Protein Sequence
(Fasta)

MAETSLLEAG TSAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL 60
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQTVKRK IRDESLCSQH HEPLSLFCYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTCTTCA CGGGCTTGCA CTTACTTGCC AGCACATCTG TCGGAACCTA CTTCTACAGA 60
AGACCAGCTG AAAGAACTAG CCACGTGGGA CTGCGCAACT ACTAGATTCT TGGACTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0042802--F:identical protein binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

mmu:79263

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001603	Ailuropoda melanoleuca	97.34	0.00e+00	946.00
IUUC-Apl-003354	Anas platyrhynchos	42.70	6.00e-107	380.00
IUUC-Aca-005381	Anolis carolinensis	71.17	0.00e+00	684.00
IUUC-Ame-011964	Astyanax mexicanus	33.84	3.00e-70	259.00
IUUC-Bta-012554	Bos taurus	95.04	3.00e-154	538.00
IUUC-Cja-019323	Callithrix jacchus	97.43	0.00e+00	923.00
IUUC-Cfa-020342	Canis familiaris	97.64	0.00e+00	943.00
IUUC-Cpo-022084	Cavia porcellus	93.62	9.00e-152	530.00
IUUC-Csa-023186	Chlorocebus sabaeus	97.64	0.00e+00	945.00
IUUC-Cho-024697	Choloepus hoffmanni	85.63	0.00e+00	843.00
IUUC-Dno-028914	Dasypus novemcinctus	44.33	2.00e-109	389.00
IUUC-Dor-031021	Dipodomys ordii	85.90	2.00e-142	499.00
IUUC-Ete-032936	Echinops telfairi	86.59	2.00e-153	535.00
IUUC-Eca-033687	Equus caballus	95.74	4.00e-155	540.00
IUUC-Eeu-034957	Erinaceus europaeus	99.09	3.00e-131	461.00
IUUC-Fca-035406	Felis catus	97.86	0.00e+00	944.00
IUUC-Fal-036705	Ficedula albicollis	46.15	3.00e-99	355.00
IUUC-Gmo-038505	Gadus morhua	34.99	1.00e-70	260.00
IUUC-Gac-041919	Gasterosteus aculeatus	36.40	6.00e-73	268.00
IUUC-Ggo-044526	Gorilla gorilla	91.75	0.00e+00	928.00
IUUC-Hsa-045719	Homo sapiens	91.75	0.00e+00	928.00
IUUC-Itr-048404	Ictidomys tridecemlineatus	96.42	0.00e+00	937.00
IUUC-Lch-049668	Latimeria chalumnae	40.58	1.00e-88	320.00
IUUC-Loc-052206	Lepisosteus oculatus	38.03	9.00e-85	307.00
IUUC-Laf-054295	Loxodonta africana	96.59	0.00e+00	938.00
IUUC-Mcc-055765	Macaca mulatta	93.06	0.00e+00	932.00
IUUC-Meu-055997	Macropus eugenii	60.37	2.00e-128	452.00
IUUC-Mmr-061030	Microcebus murinus	95.70	0.00e+00	660.00
IUUC-Mdo-062936	Monodelphis domestica	88.07	0.00e+00	842.00
IUUC-Mpu-066160	Mustela putorius furo	97.34	0.00e+00	946.00
IUUC-Mlu-068126	Myotis lucifugus	93.26	3.00e-151	527.00
IUUC-Nle-070041	Nomascus leucogenys	87.20	0.00e+00	798.00
IUUC-Opr-070394	Ochotona princeps	91.70	0.00e+00	923.00
IUUC-Oan-072828	Ornithorhynchus anatinus	57.75	5.00e-162	564.00
IUUC-Ocu-073980	Oryctolagus cuniculus	95.13	0.00e+00	678.00
IUUC-Ola-086686	Oryzias latipes	30.31	1.00e-63	237.00
IUUC-Oga-088422	Otolemur garnettii	92.75	0.00e+00	897.00
IUUC-Oar-089277	Ovis aries	92.51	0.00e+00	869.00
IUUC-Ptr-090853	Pan troglodytes	91.75	0.00e+00	928.00
IUUC-Pan-091993	Papio anubis	97.64	0.00e+00	945.00
IUUC-Psi-092975	Pelodiscus sinensis	74.31	0.00e+00	644.00
IUUC-Pma-094519	Petromyzon marinus	27.61	2.00e-28	119.00
IUUC-Pfo-096831	Poecilia formosa	32.99	1.00e-68	254.00
IUUC-Pab-097944	Pongo abelii	97.64	0.00e+00	945.00
IUUC-Pca-100795	Procavia capensis	86.89	1.00e-176	612.00
IUUC-Pva-103180	Pteropus vampyrus	90.78	0.00e+00	912.00
IUUC-Rno-105736	Rattus norvegicus	97.68	0.00e+00	951.00
IUUC-Sha-107411	Sarcophilus harrisii	53.29	1.00e-148	519.00
IUUC-Sar-113371	Sorex araneus	88.32	0.00e+00	737.00
IUUC-Ssc-116025	Sus scrofa	97.86	0.00e+00	946.00
IUUC-Tgu-116998	Taeniopygia guttata	47.06	4.00e-102	365.00
IUUC-Tsy-119072	Tarsius syrichta	85.25	1.00e-178	618.00
IUUC-Tbe-127820	Tupaia belangeri	86.03	2.00e-137	482.00
IUUC-Ttr-128310	Tursiops truncatus	99.55	6.00e-133	467.00
IUUC-Vpa-130803	Vicugna pacos	92.14	0.00e+00	931.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence