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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045728
Ensembl Protein ID ENSP00000301281.5
UniProt Accession Q9BZV1; D6W626; Q96AH1; Q96IK9; Q9BZV0; UBXN6_HUMAN
Genbank Protein ID AAK13257.1; AAK13258.1; EAW69219.1; EAW69222.1; AAH07414.2; AAH08288.1; AAH17113.1
Protein Name UBX domain-containing protein 6; UBX domain-containing protein 1
Genbank Nucleotide ID AF272893; AF272894; CH471139; CH471139; BC007414; BC008288; BC017113
Gene Name UBXN6; UBXD1; UBXDC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000167671.11 ENST00000591919.5 ENSP00000467206.1
ENSG00000167671.11 ENST00000301281.10 ENSP00000301281.5
ENSG00000167671.11 ENST00000590466.2 ENSP00000466148.2
ENSG00000167671.11 ENST00000592515.1 ENSP00000464967.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/UBX UBX 26362318
Classification
Family E-value Score Start End
ULD/UDP/UFD/UBX 1.80e-13 52.5 334 408
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/UBX
   S: 3    teqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           ++++ l++RlpdG+ l+ +F ++++l ++y fv ++l++++ pFeL+++  +++ ++e+    l+e+gLvps+ l++
   Q: 334  YNYTLLRVRLPDGCLLQGTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDENL--ALNECGLVPSALLTF 408
           67899*******************************************************..***********9986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
 Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
Protein Sequence
(Fasta)
MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL 60
ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045728|ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTTTTTTT TTTTTTTTTT TTTTTTTAAT TTTCTTCCGG TGGCTGGTCT CCGGCGGCCC 60
CGTCCCCGAC TGGGCCCCGT GCCCCCCCGC CCCCGCGGCC CCCCGCCGCC GGGCCAGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045728|ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR018997--PUB_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS50033--UBX
Pfam

PF09409--PUB
PF00789--UBX
SMART

SM00580--PUG
SM00166--UBX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
KEGG hsa:80700
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001103 Aegilops tauschii 42.86 5.00e-10 58.90
IUUC-Aml-001394 Ailuropoda melanoleuca 86.20 0.00e+00 696.00
IUUC-Atr-002503 Amborella trichopoda 29.18 2.00e-23 103.00
IUUC-Apl-003287 Anas platyrhynchos 65.46 9.00e-127 446.00
IUUC-Aca-004441 Anolis carolinensis 67.46 3.00e-144 504.00
IUUC-Aly-005477 Arabidopsis lyrata 28.62 5.00e-17 82.40
IUUC-Ath-007053 Arabidopsis thaliana 30.35 2.00e-16 80.50
IUUC-Ame-011784 Astyanax mexicanus 58.01 3.00e-124 438.00
IUUC-Bta-012994 Bos taurus 87.98 0.00e+00 742.00
IUUC-Bdi-014901 Brachypodium distachyon 30.66 3.00e-23 103.00
IUUC-Bol-016357 Brassica oleracea 32.82 1.00e-18 87.80
IUUC-Bra-017774 Brassica rapa 29.81 2.00e-20 94.00
IUUC-Cel-018297 Caenorhabditis elegans 31.45 2.00e-34 139.00
IUUC-Cja-019065 Callithrix jacchus 90.45 0.00e+00 778.00
IUUC-Cfa-020323 Canis familiaris 83.45 0.00e+00 711.00
IUUC-Cpo-022404 Cavia porcellus 79.24 0.00e+00 684.00
IUUC-Csa-023284 Chlorocebus sabaeus 96.14 0.00e+00 839.00
IUUC-Cin-025536 Ciona intestinalis 34.13 4.00e-44 172.00
IUUC-Csv-026209 Ciona savignyi 36.79 2.00e-32 132.00
IUUC-Dre-028550 Danio rerio 53.38 5.00e-101 361.00
IUUC-Dno-029718 Dasypus novemcinctus 76.11 9.00e-171 593.00
IUUC-Dor-030284 Dipodomys ordii 78.69 8.00e-179 619.00
IUUC-Dme-031962 Drosophila melanogaster 37.92 1.00e-48 187.00
IUUC-Ete-032636 Echinops telfairi 71.89 9.00e-72 264.00
IUUC-Eca-033672 Equus caballus 88.02 5.00e-170 590.00
IUUC-Fca-036036 Felis catus 87.39 2.00e-57 213.00
IUUC-Fal-037624 Ficedula albicollis 61.33 4.00e-113 401.00
IUUC-Gmo-039105 Gadus morhua 51.53 4.00e-105 374.00
IUUC-Gga-040449 Gallus gallus 63.45 2.00e-138 486.00
IUUC-Gac-042028 Gasterosteus aculeatus 53.50 1.00e-107 383.00
IUUC-Gma-042762 Glycine max 30.71 9.00e-20 91.70
IUUC-Ggo-044540 Gorilla gorilla 99.27 0.00e+00 813.00
IUUC-Hvu-047208 Hordeum vulgare 33.53 9.00e-19 87.00
IUUC-Itr-048940 Ictidomys tridecemlineatus 84.39 0.00e+00 717.00
IUUC-Lch-050216 Latimeria chalumnae 59.82 7.00e-133 467.00
IUUC-Lpe-051136 Leersia perrieri 28.13 3.00e-23 103.00
IUUC-Loc-052086 Lepisosteus oculatus 57.14 3.00e-109 388.00
IUUC-Laf-053998 Loxodonta africana 74.77 0.00e+00 644.00
IUUC-Mcc-055877 Macaca mulatta 96.59 0.00e+00 843.00
IUUC-Meu-056058 Macropus eugenii 55.56 3.00e-112 398.00
IUUC-Mtr-058198 Medicago truncatula 31.02 2.00e-20 94.00
IUUC-Mga-060105 Meleagris gallopavo 63.68 3.00e-144 504.00
IUUC-Mmr-061059 Microcebus murinus 88.21 0.00e+00 764.00
IUUC-Mdo-061899 Monodelphis domestica 74.15 4.00e-177 613.00
IUUC-Mmu-064178 Mus musculus 80.95 0.00e+00 676.00
IUUC-Mac-064698 Musa acuminata 33.33 3.00e-26 113.00
IUUC-Mpu-065804 Mustela putorius furo 87.07 0.00e+00 749.00
IUUC-Mlu-067204 Myotis lucifugus 85.26 0.00e+00 710.00
IUUC-Nle-069663 Nomascus leucogenys 97.50 0.00e+00 852.00
IUUC-Opr-071214 Ochotona princeps 83.93 8.00e-166 576.00
IUUC-Ont-071987 Oreochromis niloticus 55.37 4.00e-101 361.00
IUUC-Oan-073484 Ornithorhynchus anatinus 56.11 9.00e-106 377.00
IUUC-Ocu-073988 Oryctolagus cuniculus 60.54 6.00e-108 384.00
IUUC-Oba-075124 Oryza barthii 33.99 4.00e-18 84.70
IUUC-Obr-076731 Oryza brachyantha 29.43 1.00e-21 97.40
IUUC-Ogl-077903 Oryza glaberrima 34.64 1.00e-15 76.30
IUUC-Ogu-078325 Oryza glumaepatula 28.62 2.00e-22 100.00
IUUC-Oin-079788 Oryza indica 33.99 2.00e-17 82.80
IUUC-Olo-080748 Oryza longistaminata 32.03 2.00e-13 71.60
IUUC-Ome-081645 Oryza meridionalis 27.88 1.00e-21 97.80
IUUC-Oni-082890 Oryza nivara 28.62 3.00e-22 99.80
IUUC-Opu-083357 Oryza punctata 29.26 3.00e-22 99.40
IUUC-Oru-084284 Oryza rufipogon 28.25 2.00e-22 99.80
IUUC-Osa-086240 Oryza sativa 33.99 4.00e-18 84.70
IUUC-Ola-087409 Oryzias latipes 55.78 1.00e-105 376.00
IUUC-Olu-087606 Ostreococcus lucimarinus 37.80 2.00e-07 50.10
IUUC-Oga-089065 Otolemur garnettii 87.33 0.00e+00 755.00
IUUC-Oar-090352 Ovis aries 87.53 0.00e+00 697.00
IUUC-Ptr-091500 Pan troglodytes 98.86 0.00e+00 857.00
IUUC-Pan-092827 Papio anubis 96.59 0.00e+00 843.00
IUUC-Psi-093445 Pelodiscus sinensis 66.84 5.00e-141 493.00
IUUC-Pfo-096895 Poecilia formosa 57.29 5.00e-75 274.00
IUUC-Pab-098545 Pongo abelii 97.50 0.00e+00 838.00
IUUC-Pop-099215 Populus trichocarpa 30.51 8.00e-25 108.00
IUUC-Pca-100335 Procavia capensis 85.03 0.00e+00 743.00
IUUC-Ppe-101911 Prunus persica 27.08 6.00e-24 105.00
IUUC-Pva-103169 Pteropus vampyrus 74.55 9.00e-169 586.00
IUUC-Rno-106064 Rattus norvegicus 80.50 0.00e+00 671.00
IUUC-Sce-106458 Saccharomyces cerevisiae 33.63 5.00e-05 42.40
IUUC-Sha-107437 Sarcophilus harrisii 77.24 4.00e-53 199.00
IUUC-Sit-110426 Setaria italica 29.74 5.00e-23 102.00
IUUC-Sly-111225 Solanum lycopersicum 32.48 2.00e-24 107.00
IUUC-Stu-112826 Solanum tuberosum 32.22 8.00e-23 101.00
IUUC-Sar-113312 Sorex araneus 84.35 6.00e-132 463.00
IUUC-Sbi-114391 Sorghum bicolor 29.85 4.00e-21 95.90
IUUC-Sre-114935 Sporisorium reilianum 28.83 1.00e-06 46.60
IUUC-Ssc-115396 Sus scrofa 87.98 0.00e+00 711.00
IUUC-Tgu-116843 Taeniopygia guttata 63.48 8.00e-118 416.00
IUUC-Tru-118747 Takifugu rubripes 53.85 1.00e-103 370.00
IUUC-Tni-120834 Tetraodon nigroviridis 54.33 2.00e-102 366.00
IUUC-Tca-121181 Theobroma cacao 28.92 3.00e-22 100.00
IUUC-Tae-122844 Triticum aestivum 30.37 3.00e-26 112.00
IUUC-Tur-126442 Triticum urartu 30.74 2.00e-26 112.00
IUUC-Tbe-127541 Tupaia belangeri 71.59 2.00e-153 535.00
IUUC-Ttr-129191 Tursiops truncatus 84.81 0.00e+00 717.00
IUUC-Uma-129497 Ustilago maydis 28.95 2.00e-06 46.20
IUUC-Vvi-130861 Vitis vinifera 30.33 1.00e-25 110.00
IUUC-Xtr-132485 Xenopus tropicalis 54.73 3.00e-118 418.00
IUUC-Xma-133953 Xiphophorus maculatus 57.35 3.00e-93 335.00
Created Date 25-Jun-2017

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