iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020541.12	ENSMUST00000020849.8	ENSMUSP00000020849.2
ENSMUSG00000020541.12	ENSMUST00000107869.8	ENSMUSP00000103501.2
ENSMUSG00000020541.12	ENSMUST00000154599.1	ENSMUSP00000123329.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/GAT	2.90e-24	86.6	199	286

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/GAT

   S: 39   ekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykqlk 127
           e+i+kl+sel++vk+nvk+++++l+e++p++e++ed ell++ly+t +++++++++l+   ++n++++ el+++n++ln++++ y++++
   Q: 199  EQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQERIMDLLVV-VENEDVTMELIQVNEDLNNAVLGYERFT 286
           89**********************************************************.*************************997 PP

Organism

Mus musculus

Functional Description
(View)

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions.

Protein Sequence
(Fasta)

MAFGKSHRDP YATSVGHLIE KATFAGVLTE DWGQFLHICD IINTTQDGPK DAVKALKKRI 60
SKNYNHKEIQ LSLSLIDMCV QNCGPSFQSL IVKKEFIKDT LVKLLNPRYT LPLETQNRIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGAAGCAT GGGTATCTGA TGTTAGCCGT GCCGCGGAAA AGGAAAAAGA AATCTTGGTT 60
CAAATAGAAA CAGAGAGGTT TGGTTTCTTA ATGTGGATTT ACATACCAAA CATATTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR027428--TOM1L1
IPR002014--VHS_dom

PROSITE

PS50909--GAT
PS50179--VHS

Pfam

PF03127--GAT
PF00790--VHS

SMART

SM00288--VHS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005795--C:Golgi stack
GO:0030276--F:clathrin binding
GO:0030295--F:protein kinase activator activity
GO:0019901--F:protein kinase binding
GO:0032147--P:activation of protein kinase activity
GO:0006886--P:intracellular protein transport
GO:0045839--P:negative regulation of mitotic nuclear division
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0007165--P:signal transduction
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001565	Ailuropoda melanoleuca	79.50	0.00e+00	716.00
IUUC-Apl-004174	Anas platyrhynchos	52.00	2.00e-88	319.00
IUUC-Bta-012349	Bos taurus	75.99	0.00e+00	658.00
IUUC-Cja-019078	Callithrix jacchus	80.54	0.00e+00	748.00
IUUC-Cfa-020228	Canis familiaris	77.64	0.00e+00	672.00
IUUC-Cpo-021541	Cavia porcellus	72.92	8.00e-175	606.00
IUUC-Csa-024260	Chlorocebus sabaeus	78.56	1.00e-179	622.00
IUUC-Cho-025095	Choloepus hoffmanni	62.09	4.00e-150	524.00
IUUC-Dno-029738	Dasypus novemcinctus	76.83	0.00e+00	664.00
IUUC-Dor-030805	Dipodomys ordii	70.74	4.00e-175	607.00
IUUC-Ete-032525	Echinops telfairi	72.27	4.00e-179	620.00
IUUC-Eeu-034961	Erinaceus europaeus	58.27	1.00e-78	286.00
IUUC-Fca-036355	Felis catus	78.17	0.00e+00	711.00
IUUC-Fal-036691	Ficedula albicollis	50.31	6.00e-119	421.00
IUUC-Gga-040722	Gallus gallus	50.10	3.00e-117	415.00
IUUC-Ggo-044686	Gorilla gorilla	77.62	0.00e+00	701.00
IUUC-Hsa-046281	Homo sapiens	78.03	0.00e+00	705.00
IUUC-Itr-048619	Ictidomys tridecemlineatus	84.08	4.00e-166	577.00
IUUC-Lch-050448	Latimeria chalumnae	45.62	6.00e-106	377.00
IUUC-Laf-054440	Loxodonta africana	75.00	0.00e+00	675.00
IUUC-Mcc-055179	Macaca mulatta	74.56	2.00e-147	515.00
IUUC-Meu-056149	Macropus eugenii	57.02	4.00e-131	461.00
IUUC-Mga-059815	Meleagris gallopavo	55.99	1.00e-108	385.00
IUUC-Mmr-061673	Microcebus murinus	81.21	0.00e+00	707.00
IUUC-Mdo-062647	Monodelphis domestica	61.86	4.00e-153	534.00
IUUC-Mpu-065968	Mustela putorius furo	78.08	0.00e+00	712.00
IUUC-Mlu-067663	Myotis lucifugus	75.78	0.00e+00	692.00
IUUC-Nle-069514	Nomascus leucogenys	78.03	0.00e+00	707.00
IUUC-Opr-070400	Ochotona princeps	70.26	1.00e-153	536.00
IUUC-Ocu-074210	Oryctolagus cuniculus	77.34	0.00e+00	678.00
IUUC-Oga-088524	Otolemur garnettii	75.37	3.00e-172	597.00
IUUC-Oar-090252	Ovis aries	75.00	1.00e-177	615.00
IUUC-Ptr-090624	Pan troglodytes	78.03	0.00e+00	703.00
IUUC-Pan-092547	Papio anubis	78.66	0.00e+00	679.00
IUUC-Psi-093440	Pelodiscus sinensis	54.33	6.00e-134	471.00
IUUC-Pab-097710	Pongo abelii	89.47	7.00e-148	516.00
IUUC-Pca-100911	Procavia capensis	67.10	4.00e-155	541.00
IUUC-Pva-102626	Pteropus vampyrus	76.20	0.00e+00	700.00
IUUC-Rno-105217	Rattus norvegicus	89.71	0.00e+00	850.00
IUUC-Sha-107467	Sarcophilus harrisii	60.39	5.00e-124	437.00
IUUC-Sar-113062	Sorex araneus	64.99	9.00e-135	473.00
IUUC-Ssc-116377	Sus scrofa	72.14	2.00e-173	602.00
IUUC-Tgu-116578	Taeniopygia guttata	64.71	4.00e-80	290.00
IUUC-Tsy-119264	Tarsius syrichta	72.38	6.00e-173	600.00
IUUC-Tbe-127731	Tupaia belangeri	65.00	2.00e-80	292.00
IUUC-Ttr-128951	Tursiops truncatus	74.48	0.00e+00	645.00
IUUC-Vpa-130520	Vicugna pacos	68.34	3.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence