• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045786
UUCD1 version UUC-HoS-00152
Ensembl Protein ID ENSP00000298068.5
UniProt Accession Q5U5R9; Q5VZ97; Q5VZ98; Q5VZ99; Q8N1X7; Q8TCP5; HECD2_HUMAN
Genbank Protein ID BAC04388.1; CAH70050.1; CAH70052.1; CAH70052.1; CAH70053.1; CAH70053.1; EAW50111.1; AAH40187.1; CAD28480.1
Protein Name Probable E3 ubiquitin-protein ligase HECTD2; HECT domain-containing protein 2; HECT-type E3 ubiquitin transferase HECTD2
Genbank Nucleotide ID AK094625; AL161798; AL161798; AC023902; AL161798; AC023902; CH471066; BC040187; AL713675
Gene Name HECTD2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165338.16 ENST00000371681.8 ENSP00000360746.4
ENSG00000165338.16 ENST00000298068.9 ENSP00000298068.5
ENSG00000165338.16 ENST00000446394.5 ENSP00000401023.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancer
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20175895; 19214206
Classification
Family E-value Score Start End
E3 activity/HECT 3.40e-102 344.0 438 776
Active Site
Position(s) Description Evidence
744 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld++++
   Q: 438  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDIRFP 524
           589***************************************************87766.....789************************* PP
   S: 94   ksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
           +++yk+ll+               +++++dl +++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgG++i+Vtn+N++
   Q: 525  PCCYKKLLSPpiipsdqnipvgicNVTVDDLCQIMPELAHGLSELLSH-EGNVEED-FYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRK 614
           **********777777766666666*********************98.6788885.*********************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++++d+++l++ t+y+g y +++ +i++Fw+v+ +f  + +k+
   Q: 615  EYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDVVLGFPLDLQKK 705
           ****************************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +L+F+Tgs+r+P+gG+a+l+   f i+k ++s++ lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 706  LLHFTTGSDRVPVGGMADLN---FKISKnETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
           ********************...9999966777**************************************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MSEAVRVPSP ATPLVVAAPA PEERKGKESE REKLPPIVSA GAGATAGLDR GAKGQISTFS 60
SFISAVSPKK EAAENRSSPA HLVFPNIKNV REPPPICLDV RQKQRTSMDA SSSEMKAPVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045786|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGGAAAGG AAATTGTCTA GGTGTCCTGG TGGTGGAGGT GGGGGGTATT TTAATTTCAT 60
AATTAAAAGC TCTCTTCTTC GGCTTTCAAG TTTTTACTCC TATTTGTAAT GATTTGATTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045786|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
PROSITE

PS50237--HECT
Pfam

PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
KEGG hsa:143279
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001266 Ailuropoda melanoleuca 95.10 0.00e+00 1457.00
IUUC-Apl-003589 Anas platyrhynchos 84.95 0.00e+00 1285.00
IUUC-Aca-004350 Anolis carolinensis 79.95 0.00e+00 1211.00
IUUC-Ago-007908 Ashbya gossypii 34.60 6.00e-83 302.00
IUUC-Acl-008288 Aspergillus clavatus 34.70 1.00e-97 352.00
IUUC-Afl-008402 Aspergillus flavus 33.88 1.00e-91 330.00
IUUC-Afu-008762 Aspergillus fumigatus 33.99 6.00e-95 342.00
IUUC-Ani-009176 Aspergillus nidulans 34.72 2.00e-93 337.00
IUUC-Ang-009791 Aspergillus niger 35.04 2.00e-93 337.00
IUUC-Aor-009921 Aspergillus oryzae 33.50 1.00e-90 328.00
IUUC-Ate-010295 Aspergillus terreus 35.16 1.00e-100 361.00
IUUC-Ame-010660 Astyanax mexicanus 81.61 2.00e-150 524.00
IUUC-Bgr-011981 Blumeria graminis 31.86 2.00e-95 344.00
IUUC-Bta-012945 Bos taurus 93.51 0.00e+00 1422.00
IUUC-Bci-013697 Botrytis cinerea 33.06 2.00e-81 298.00
IUUC-Cja-019263 Callithrix jacchus 97.18 0.00e+00 1471.00
IUUC-Cfa-020486 Canis familiaris 96.43 0.00e+00 1312.00
IUUC-Cpo-021755 Cavia porcellus 92.99 0.00e+00 1442.00
IUUC-Csa-023814 Chlorocebus sabaeus 98.71 0.00e+00 1413.00
IUUC-Cho-024980 Choloepus hoffmanni 77.71 0.00e+00 1157.00
IUUC-Cgl-026526 Colletotrichum gloeosporioides 42.05 4.00e-99 356.00
IUUC-Dre-028551 Danio rerio 74.83 0.00e+00 1152.00
IUUC-Dno-029497 Dasypus novemcinctus 92.61 0.00e+00 1287.00
IUUC-Dor-030867 Dipodomys ordii 81.76 0.00e+00 1189.00
IUUC-Dse-031239 Dothistroma septosporum 29.27 3.00e-90 327.00
IUUC-Ete-032902 Echinops telfairi 78.65 0.00e+00 1187.00
IUUC-Eca-033678 Equus caballus 94.93 0.00e+00 1432.00
IUUC-Eeu-035262 Erinaceus europaeus 77.41 0.00e+00 1058.00
IUUC-Fca-035590 Felis catus 95.21 0.00e+00 1461.00
IUUC-Fal-037123 Ficedula albicollis 80.39 0.00e+00 1239.00
IUUC-Fox-037941 Fusarium oxysporum 39.68 2.00e-101 364.00
IUUC-Fso-038388 Fusarium solani 40.28 6.00e-104 372.00
IUUC-Gmo-039553 Gadus morhua 66.46 0.00e+00 853.00
IUUC-Ggr-040110 Gaeumannomyces graminis 31.98 2.00e-100 361.00
IUUC-Gga-040406 Gallus gallus 84.32 0.00e+00 1325.00
IUUC-Gac-042141 Gasterosteus aculeatus 75.22 0.00e+00 1107.00
IUUC-Ggo-045504 Gorilla gorilla 98.97 0.00e+00 1508.00
IUUC-Itr-048050 Ictidomys tridecemlineatus 88.52 0.00e+00 1235.00
IUUC-Kpa-049152 Komagataella pastoris 33.98 5.00e-78 286.00
IUUC-Lch-049824 Latimeria chalumnae 80.43 0.00e+00 1107.00
IUUC-Loc-052173 Lepisosteus oculatus 78.04 0.00e+00 1206.00
IUUC-Laf-054017 Loxodonta africana 94.18 0.00e+00 1345.00
IUUC-Mcc-055713 Macaca mulatta 97.98 0.00e+00 1461.00
IUUC-Meu-056212 Macropus eugenii 68.50 4.00e-115 408.00
IUUC-Mor-057045 Magnaporthe oryzae 36.59 2.00e-92 334.00
IUUC-Mla-059187 Melampsora laricipopulina 43.83 4.00e-88 318.00
IUUC-Mga-059884 Meleagris gallopavo 78.83 0.00e+00 1167.00
IUUC-Mmr-061344 Microcebus murinus 92.80 0.00e+00 1419.00
IUUC-Mdo-062653 Monodelphis domestica 87.05 0.00e+00 1327.00
IUUC-Mmu-063775 Mus musculus 90.22 0.00e+00 1305.00
IUUC-Mpu-066069 Mustela putorius furo 96.37 0.00e+00 1342.00
IUUC-Mlu-067925 Myotis lucifugus 93.84 0.00e+00 1394.00
IUUC-Nfi-068439 Neosartorya fischeri 33.99 3.00e-95 343.00
IUUC-Ncr-068903 Neurospora crassa 37.07 4.00e-94 340.00
IUUC-Nle-070046 Nomascus leucogenys 98.13 0.00e+00 1506.00
IUUC-Opr-071085 Ochotona princeps 79.19 2.00e-137 483.00
IUUC-Ont-072126 Oreochromis niloticus 72.32 0.00e+00 1166.00
IUUC-Oan-072933 Ornithorhynchus anatinus 88.87 0.00e+00 1192.00
IUUC-Ocu-073800 Oryctolagus cuniculus 95.92 0.00e+00 1318.00
IUUC-Ola-086988 Oryzias latipes 75.69 0.00e+00 1118.00
IUUC-Oga-088117 Otolemur garnettii 95.17 0.00e+00 1140.00
IUUC-Oar-089371 Ovis aries 93.42 0.00e+00 1383.00
IUUC-Ptr-090551 Pan troglodytes 98.46 0.00e+00 1450.00
IUUC-Pan-092067 Papio anubis 98.51 0.00e+00 1466.00
IUUC-Psi-092963 Pelodiscus sinensis 84.93 0.00e+00 1276.00
IUUC-Pfo-096562 Poecilia formosa 69.97 0.00e+00 1126.00
IUUC-Pab-098680 Pongo abelii 98.97 0.00e+00 1508.00
IUUC-Pca-100986 Procavia capensis 75.17 0.00e+00 909.00
IUUC-Pva-102219 Pteropus vampyrus 79.29 0.00e+00 1095.00
IUUC-Pgr-103315 Puccinia graminis 36.21 1.00e-95 344.00
IUUC-Ptt-103736 Puccinia triticina 41.49 2.00e-95 343.00
IUUC-Rno-105270 Rattus norvegicus 89.05 0.00e+00 1313.00
IUUC-Sce-106306 Saccharomyces cerevisiae 34.25 5.00e-70 259.00
IUUC-Sha-106819 Sarcophilus harrisii 89.59 0.00e+00 1375.00
IUUC-Spo-108271 Schizosaccharomyces pombe 32.47 1.00e-88 321.00
IUUC-Ssl-108657 Sclerotinia sclerotiorum 30.53 1.00e-85 311.00
IUUC-Sar-113134 Sorex araneus 85.21 0.00e+00 1241.00
IUUC-Ssc-115441 Sus scrofa 94.33 0.00e+00 1402.00
IUUC-Tgu-117166 Taeniopygia guttata 83.31 0.00e+00 1258.00
IUUC-Tsy-118898 Tarsius syrichta 82.26 0.00e+00 1152.00
IUUC-Tre-122108 Trichoderma reesei 38.18 1.00e-90 328.00
IUUC-Tvi-122644 Trichoderma virens 38.31 2.00e-95 344.00
IUUC-Tme-127004 Tuber melanosporum 34.40 9.00e-104 372.00
IUUC-Tbe-127292 Tupaia belangeri 78.22 0.00e+00 1084.00
IUUC-Ttr-128352 Tursiops truncatus 90.82 0.00e+00 1353.00
IUUC-Vda-129969 Verticillium dahliae 40.44 2.00e-95 344.00
IUUC-Vpa-130218 Vicugna pacos 92.21 0.00e+00 1022.00
IUUC-Xtr-132594 Xenopus tropicalis 77.47 0.00e+00 1189.00
IUUC-Xma-134157 Xiphophorus maculatus 74.81 0.00e+00 1048.00
IUUC-Yli-134470 Yarrowia lipolytica 34.55 1.00e-78 288.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved