iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000022840.15	ENST00000325954.8	ENSP00000322242.4
ENSG00000022840.15	ENST00000542438.1	ENSP00000444770.1
ENSG00000022840.15	ENST00000538796.5	ENSP00000443000.1
ENSG00000022840.15	ENST00000413266.6	ENSP00000415682.2
ENSG00000022840.15	ENST00000536869.5	ENSP00000443790.1
ENSG00000022840.15	ENST00000537997.1	ENSP00000443235.1
ENSG00000022840.15	ENST00000542207.5	ENSP00000439510.1
ENSG00000022840.15	ENST00000537740.1	ENSP00000437392.1
ENSG00000022840.15	ENST00000540046.5	ENSP00000439859.1
ENSG00000022840.15	ENST00000545419.5	ENSP00000445160.1
ENSG00000022840.15	ENST00000538254.1	ENSP00000441487.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	24105792

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.20e-06	29.7	225	266

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCl+++    ++++CgH+f+  C+ ++  l+ s+++  +CP+C
   Q: 225  CPICLYPPTA-AKITRCGHIFCWACILHY--LSLSEKTWSKCPIC 266
           ********99.99*************999..5545666669**** PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Protein Sequence
(Fasta)

MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS 60
KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTACACGCA TGAAACACTG CTTATGGCCT GTTTCCGCCT CTGTCTCCTG GGTAATGGGG 60
ACCACAGGTG CGCACCGCCA CGCCAGGCTA AAGAAATAAA GTGATGTACT GTATGAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0010626--P:negative regulation of Schwann cell proliferation
GO:0031643--P:positive regulation of myelination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051865--P:protein autoubiquitination
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9921

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000074	Aegilops tauschii	37.36	4.00e-34	139.00
IUUC-Aml-002043	Ailuropoda melanoleuca	91.95	0.00e+00	981.00
IUUC-Atr-003135	Amborella trichopoda	36.67	6.00e-30	126.00
IUUC-Apl-003850	Anas platyrhynchos	71.86	0.00e+00	799.00
IUUC-Aca-005315	Anolis carolinensis	70.47	0.00e+00	964.00
IUUC-Aly-005597	Arabidopsis lyrata	29.16	4.00e-44	173.00
IUUC-Ago-007969	Ashbya gossypii	28.11	9.00e-14	72.40
IUUC-Acl-008291	Aspergillus clavatus	34.04	3.00e-25	110.00
IUUC-Afl-008511	Aspergillus flavus	27.12	2.00e-40	160.00
IUUC-Afu-008924	Aspergillus fumigatus	31.38	5.00e-24	106.00
IUUC-Ani-009492	Aspergillus nidulans	24.95	7.00e-31	129.00
IUUC-Ang-009588	Aspergillus niger	32.45	2.00e-25	110.00
IUUC-Aor-010006	Aspergillus oryzae	27.12	1.00e-40	161.00
IUUC-Ate-010373	Aspergillus terreus	25.10	1.00e-32	135.00
IUUC-Ame-011589	Astyanax mexicanus	58.04	0.00e+00	712.00
IUUC-Bgr-012151	Blumeria graminis	31.82	2.00e-21	97.40
IUUC-Bta-012512	Bos taurus	93.71	0.00e+00	1299.00
IUUC-Bci-013967	Botrytis cinerea	26.61	3.00e-23	103.00
IUUC-Bdi-014819	Brachypodium distachyon	29.03	5.00e-51	196.00
IUUC-Bol-015780	Brassica oleracea	28.38	4.00e-44	173.00
IUUC-Bra-016966	Brassica rapa	36.69	4.00e-27	116.00
IUUC-Cja-019028	Callithrix jacchus	92.09	0.00e+00	1333.00
IUUC-Cfa-021190	Canis familiaris	92.28	0.00e+00	1277.00
IUUC-Cpo-021765	Cavia porcellus	93.96	0.00e+00	1338.00
IUUC-Cre-022687	Chlamydomonas reinhardtii	32.03	8.00e-10	58.20
IUUC-Csa-023675	Chlorocebus sabaeus	98.95	0.00e+00	1309.00
IUUC-Cho-024480	Choloepus hoffmanni	94.57	0.00e+00	1029.00
IUUC-Cin-025421	Ciona intestinalis	35.91	1.00e-50	194.00
IUUC-Csv-026061	Ciona savignyi	37.52	1.00e-92	334.00
IUUC-Cgl-026594	Colletotrichum gloeosporioides	25.81	1.00e-26	114.00
IUUC-Cne-026993	Cryptococcus neoformans	33.99	7.00e-18	86.30
IUUC-Dre-027622	Danio rerio	55.63	0.00e+00	695.00
IUUC-Dno-029504	Dasypus novemcinctus	92.44	0.00e+00	1267.00
IUUC-Dor-030517	Dipodomys ordii	94.73	0.00e+00	1055.00
IUUC-Dse-031271	Dothistroma septosporum	28.82	1.00e-22	101.00
IUUC-Dme-031728	Drosophila melanogaster	35.71	2.00e-48	187.00
IUUC-Ete-032954	Echinops telfairi	62.97	3.00e-108	385.00
IUUC-Eca-033210	Equus caballus	94.46	0.00e+00	1373.00
IUUC-Eeu-034741	Erinaceus europaeus	83.14	0.00e+00	726.00
IUUC-Fca-035704	Felis catus	92.36	0.00e+00	1278.00
IUUC-Fal-037450	Ficedula albicollis	72.22	0.00e+00	926.00
IUUC-Fox-037977	Fusarium oxysporum	28.90	8.00e-26	112.00
IUUC-Fso-038372	Fusarium solani	28.67	2.00e-27	117.00
IUUC-Gmo-038682	Gadus morhua	54.71	0.00e+00	701.00
IUUC-Ggr-039911	Gaeumannomyces graminis	27.02	8.00e-25	108.00
IUUC-Gga-040648	Gallus gallus	73.06	0.00e+00	943.00
IUUC-Gac-042056	Gasterosteus aculeatus	54.55	0.00e+00	654.00
IUUC-Gma-043144	Glycine max	34.39	2.00e-27	117.00
IUUC-Ggo-045420	Gorilla gorilla	99.87	0.00e+00	1397.00
IUUC-Hvu-047535	Hordeum vulgare	37.36	2.00e-34	140.00
IUUC-Itr-048580	Ictidomys tridecemlineatus	93.49	0.00e+00	1264.00
IUUC-Kpa-049131	Komagataella pastoris	27.07	6.00e-13	69.30
IUUC-Lch-050373	Latimeria chalumnae	66.84	0.00e+00	904.00
IUUC-Lpe-051155	Leersia perrieri	28.31	4.00e-52	199.00
IUUC-Loc-052182	Lepisosteus oculatus	58.61	0.00e+00	745.00
IUUC-Lma-053242	Leptosphaeria maculans	26.76	8.00e-24	106.00
IUUC-Laf-054048	Loxodonta africana	93.82	0.00e+00	1263.00
IUUC-Mcc-055802	Macaca mulatta	98.28	0.00e+00	1372.00
IUUC-Meu-056641	Macropus eugenii	63.33	4.00e-106	379.00
IUUC-Mor-057233	Magnaporthe oryzae	27.84	2.00e-25	110.00
IUUC-Mtr-057767	Medicago truncatula	30.62	8.00e-51	195.00
IUUC-Mla-058967	Melampsora laricipopulina	28.01	3.00e-37	150.00
IUUC-Mga-059783	Meleagris gallopavo	72.64	0.00e+00	970.00
IUUC-Mvi-060430	Microbotryum violaceum	38.64	4.00e-28	120.00
IUUC-Mmr-060953	Microcebus murinus	95.44	0.00e+00	1309.00
IUUC-Mdo-063070	Monodelphis domestica	78.02	0.00e+00	1056.00
IUUC-Mmu-064077	Mus musculus	90.39	0.00e+00	1180.00
IUUC-Mac-065163	Musa acuminata	30.98	5.00e-51	196.00
IUUC-Mpu-066698	Mustela putorius furo	92.85	0.00e+00	1282.00
IUUC-Mlu-067126	Myotis lucifugus	91.12	0.00e+00	1268.00
IUUC-Nfi-068605	Neosartorya fischeri	31.91	2.00e-24	107.00
IUUC-Ncr-068754	Neurospora crassa	31.17	1.00e-20	95.10
IUUC-Nle-070138	Nomascus leucogenys	99.37	0.00e+00	1371.00
IUUC-Opr-070959	Ochotona princeps	86.08	0.00e+00	1174.00
IUUC-Ont-072344	Oreochromis niloticus	55.60	0.00e+00	665.00
IUUC-Oan-073664	Ornithorhynchus anatinus	83.33	8.00e-169	587.00
IUUC-Ocu-074463	Oryctolagus cuniculus	86.60	0.00e+00	1113.00
IUUC-Oba-075523	Oryza barthii	33.80	9.00e-34	139.00
IUUC-Obr-076032	Oryza brachyantha	32.20	5.00e-33	136.00
IUUC-Ogl-077231	Oryza glaberrima	33.80	2.00e-33	137.00
IUUC-Ogu-078117	Oryza glumaepatula	29.12	3.00e-55	210.00
IUUC-Oin-079998	Oryza indica	33.33	6.00e-33	135.00
IUUC-Olo-080870	Oryza longistaminata	33.80	5.00e-33	136.00
IUUC-Ome-081402	Oryza meridionalis	32.51	1.00e-33	138.00
IUUC-Oni-082566	Oryza nivara	33.80	1.00e-33	138.00
IUUC-Opu-083226	Oryza punctata	33.80	3.00e-33	137.00
IUUC-Oru-084192	Oryza rufipogon	33.33	3.00e-33	137.00
IUUC-Osa-086156	Oryza sativa	31.69	1.00e-33	138.00
IUUC-Ola-086980	Oryzias latipes	56.54	0.00e+00	680.00
IUUC-Olu-087613	Ostreococcus lucimarinus	30.41	3.00e-18	87.00
IUUC-Oga-088829	Otolemur garnettii	91.45	0.00e+00	1248.00
IUUC-Oar-089979	Ovis aries	93.43	0.00e+00	1251.00
IUUC-Ptr-091080	Pan troglodytes	99.63	0.00e+00	1416.00
IUUC-Pan-092604	Papio anubis	98.77	0.00e+00	1377.00
IUUC-Psi-093248	Pelodiscus sinensis	73.92	0.00e+00	990.00
IUUC-Pma-094260	Petromyzon marinus	48.06	1.00e-57	218.00
IUUC-Pno-095113	Phaeosphaeria nodorum	25.71	5.00e-24	106.00
IUUC-Pfo-097012	Poecilia formosa	55.22	0.00e+00	627.00
IUUC-Pab-098745	Pongo abelii	99.66	0.00e+00	1089.00
IUUC-Pop-099889	Populus trichocarpa	36.05	5.00e-28	119.00
IUUC-Pca-100895	Procavia capensis	85.08	0.00e+00	1144.00
IUUC-Pva-102617	Pteropus vampyrus	94.35	0.00e+00	1285.00
IUUC-Pgr-103385	Puccinia graminis	29.38	1.00e-39	158.00
IUUC-Ptt-103845	Puccinia triticina	29.09	2.00e-39	157.00
IUUC-Pte-104025	Pyrenophora teres	26.26	5.00e-24	106.00
IUUC-Pyt-104699	Pyrenophora triticirepentis	25.90	6.00e-23	102.00
IUUC-Rno-105232	Rattus norvegicus	90.38	0.00e+00	1277.00
IUUC-Sce-106225	Saccharomyces cerevisiae	26.04	7.00e-12	65.90
IUUC-Sha-106788	Sarcophilus harrisii	78.98	0.00e+00	1023.00
IUUC-Spo-108070	Schizosaccharomyces pombe	33.33	4.00e-29	123.00
IUUC-Ssl-108567	Sclerotinia sclerotiorum	26.61	2.00e-21	98.20
IUUC-Sly-110950	Solanum lycopersicum	39.09	3.00e-19	90.10
IUUC-Sar-113085	Sorex araneus	88.65	0.00e+00	1116.00
IUUC-Sbi-114553	Sorghum bicolor	38.01	1.00e-33	138.00
IUUC-Sre-115103	Sporisorium reilianum	39.86	5.00e-29	123.00
IUUC-Ssc-115675	Sus scrofa	94.63	0.00e+00	963.00
IUUC-Tgu-116506	Taeniopygia guttata	68.58	0.00e+00	925.00
IUUC-Tru-118158	Takifugu rubripes	56.09	0.00e+00	660.00
IUUC-Tsy-119477	Tarsius syrichta	87.50	0.00e+00	1134.00
IUUC-Tni-120482	Tetraodon nigroviridis	51.74	0.00e+00	647.00
IUUC-Tca-120997	Theobroma cacao	31.22	3.00e-52	199.00
IUUC-Tre-121948	Trichoderma reesei	32.87	4.00e-27	116.00
IUUC-Tvi-122648	Trichoderma virens	31.63	5.00e-26	112.00
IUUC-Tae-124316	Triticum aestivum	37.14	1.00e-34	141.00
IUUC-Tme-127224	Tuber melanosporum	25.75	3.00e-20	94.00
IUUC-Tbe-128091	Tupaia belangeri	92.05	3.00e-176	612.00
IUUC-Ttr-128830	Tursiops truncatus	85.82	0.00e+00	1174.00
IUUC-Uma-129360	Ustilago maydis	40.00	2.00e-28	121.00
IUUC-Vda-129856	Verticillium dahliae	34.46	7.00e-21	95.90
IUUC-Vpa-130094	Vicugna pacos	94.63	0.00e+00	992.00
IUUC-Vvi-131165	Vitis vinifera	37.42	2.00e-25	111.00
IUUC-Xtr-132916	Xenopus tropicalis	60.88	0.00e+00	802.00
IUUC-Xma-134009	Xiphophorus maculatus	67.26	3.00e-75	275.00
IUUC-Yli-134346	Yarrowia lipolytica	27.13	4.00e-13	69.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence