iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040177

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 6

Genbank Nucleotide ID

AADN04000136

Gene Name

SOCS6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000013731.5	ENSGALT00000022316.5	ENSGALP00000036145.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.90e-17	62.2	487	534

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 487  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 534
           5788999********************888...***************997 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MKKISLKTIR KSFNLNKSKD ESDFVVVQQP SLSEFGKDDS LFGSCYGKDL ASCEVNSEDE 60
KGGKNRSKSE SLMGTLKRRL SAKQKQKGKG STPSGSSADD DTFSSSSAPI TFKDVRAQRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGATGGCTC TTGAAGTTAA ATGAGTCTGG ATAAAACACA AATGAAGCAG AAGCTGCTCT 60
GCATGTGTTA GGGCTATATC ACCACAAGCA CTGCTGATCA GCCAGACTTG GTAACTTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

gga:421020

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	90.28	0.00e+00	902.00
IUUC-Apl-004035	Anas platyrhynchos	99.06	0.00e+00	971.00
IUUC-Aca-004782	Anolis carolinensis	93.27	0.00e+00	910.00
IUUC-Ame-011790	Astyanax mexicanus	70.02	0.00e+00	649.00
IUUC-Bta-012579	Bos taurus	94.20	2.00e-108	385.00
IUUC-Cel-018643	Caenorhabditis elegans	33.59	8.00e-12	63.20
IUUC-Cja-019528	Callithrix jacchus	90.28	0.00e+00	952.00
IUUC-Cfa-020678	Canis familiaris	89.91	0.00e+00	928.00
IUUC-Cpo-021947	Cavia porcellus	89.91	0.00e+00	958.00
IUUC-Csa-023935	Chlorocebus sabaeus	89.72	0.00e+00	922.00
IUUC-Cho-024477	Choloepus hoffmanni	88.04	0.00e+00	930.00
IUUC-Cin-025413	Ciona intestinalis	68.24	2.00e-66	246.00
IUUC-Csv-026247	Ciona savignyi	67.47	5.00e-65	241.00
IUUC-Cne-026906	Cryptococcus neoformans	22.92	1.30e+00	28.10
IUUC-Dre-027636	Danio rerio	70.34	0.00e+00	652.00
IUUC-Dno-029048	Dasypus novemcinctus	90.65	0.00e+00	929.00
IUUC-Dor-030401	Dipodomys ordii	86.01	0.00e+00	867.00
IUUC-Ete-033116	Echinops telfairi	48.23	6.00e-57	213.00
IUUC-Eca-033825	Equus caballus	90.84	0.00e+00	885.00
IUUC-Fca-036253	Felis catus	88.97	0.00e+00	827.00
IUUC-Fal-037614	Ficedula albicollis	97.75	0.00e+00	959.00
IUUC-Fox-037898	Fusarium oxysporum	28.05	5.00e-03	34.70
IUUC-Gmo-038928	Gadus morhua	68.82	0.00e+00	673.00
IUUC-Gac-042263	Gasterosteus aculeatus	71.40	0.00e+00	715.00
IUUC-Ggo-045288	Gorilla gorilla	89.91	0.00e+00	926.00
IUUC-Hsa-046409	Homo sapiens	90.28	0.00e+00	929.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	88.04	0.00e+00	879.00
IUUC-Lch-050354	Latimeria chalumnae	86.94	0.00e+00	894.00
IUUC-Loc-052319	Lepisosteus oculatus	83.21	0.00e+00	842.00
IUUC-Laf-054070	Loxodonta africana	88.04	0.00e+00	886.00
IUUC-Mcc-055045	Macaca mulatta	89.72	0.00e+00	921.00
IUUC-Meu-055917	Macropus eugenii	94.02	0.00e+00	996.00
IUUC-Mga-059273	Meleagris gallopavo	98.88	0.00e+00	965.00
IUUC-Mmr-061597	Microcebus murinus	89.91	0.00e+00	922.00
IUUC-Mdo-062492	Monodelphis domestica	70.55	7.00e-121	426.00
IUUC-Mmu-063374	Mus musculus	79.74	0.00e+00	802.00
IUUC-Mpu-065967	Mustela putorius furo	85.61	0.00e+00	860.00
IUUC-Mlu-067532	Myotis lucifugus	88.41	0.00e+00	885.00
IUUC-Nle-069373	Nomascus leucogenys	90.09	0.00e+00	926.00
IUUC-Opr-070873	Ochotona princeps	87.29	0.00e+00	921.00
IUUC-Ont-072498	Oreochromis niloticus	71.22	0.00e+00	745.00
IUUC-Oan-072943	Ornithorhynchus anatinus	73.80	2.00e-101	362.00
IUUC-Ocu-073870	Oryctolagus cuniculus	88.60	0.00e+00	907.00
IUUC-Ola-086866	Oryzias latipes	88.48	1.00e-104	372.00
IUUC-Oga-089057	Otolemur garnettii	87.85	0.00e+00	879.00
IUUC-Oar-089841	Ovis aries	58.96	3.00e-160	557.00
IUUC-Ptr-091054	Pan troglodytes	90.28	0.00e+00	927.00
IUUC-Pma-094253	Petromyzon marinus	44.44	1.00e-102	366.00
IUUC-Pfo-097179	Poecilia formosa	66.42	2.00e-179	622.00
IUUC-Pab-097702	Pongo abelii	90.09	0.00e+00	927.00
IUUC-Pca-100671	Procavia capensis	79.11	2.00e-122	432.00
IUUC-Rno-106044	Rattus norvegicus	77.17	0.00e+00	790.00
IUUC-Sha-107139	Sarcophilus harrisii	93.37	0.00e+00	914.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	4.90e-02	31.20
IUUC-Ssc-115343	Sus scrofa	87.48	0.00e+00	905.00
IUUC-Tgu-117061	Taeniopygia guttata	98.31	0.00e+00	964.00
IUUC-Tni-119829	Tetraodon nigroviridis	67.84	0.00e+00	658.00
IUUC-Tae-123723	Triticum aestivum	34.15	6.10e-01	29.60
IUUC-Ttr-129148	Tursiops truncatus	87.10	0.00e+00	855.00
IUUC-Vpa-130780	Vicugna pacos	84.86	0.00e+00	832.00
IUUC-Vvi-130966	Vitis vinifera	32.69	8.00e-02	30.40
IUUC-Xtr-132513	Xenopus tropicalis	87.10	0.00e+00	889.00
IUUC-Xma-133904	Xiphophorus maculatus	70.06	0.00e+00	680.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence