iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	20140218

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-16	60.2	234	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 9    seprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLlyed 51
            ep +L++LCR++Ir+ +g+++l ++i++L+LP s+k YLly++
   Q: 234  PEPLPLMDLCRRTIRQKIGRTNLeEHIQQLQLPLSMKTYLLYKN 277
           78****************************************97 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Involved in the localization of vas to the posterior pole of the oocyte. Required maternally in the germ line for efficient primordial germ cell formation.

Protein Sequence
(Fasta)

MGQKISGGVK TVSRNDSQST FKPIIPRELQ ADFVKPARID ILLDMPPASR DLQLKHSWNS 60
EDRSLNIFVK EDDKLTFHRH PVAQSTDCIR GKVGLTKGLH IWEIYWPTRQ RGTHAVVGVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAATGAATG TTTTGTGCAT CAAAGGTTCC TGAGTGATAT TTTGCTTTAT GTGTTGTTTT 60
ATTTTAATCA TAGCAAATCG ACAAGATAAA AGTAATGTAA GTTTCACAGG AACTGATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005938--C:cell cortex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0070449--C:elongin complex
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0045495--C:pole plasm
GO:0035017--P:cuticle pattern formation
GO:0046843--P:dorsal appendage formation
GO:0007281--P:germ cell development
GO:0035556--P:intracellular signal transduction
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0007280--P:pole cell migration
GO:0007315--P:pole plasm assembly
GO:0045732--P:positive regulation of protein catabolic process
GO:0008104--P:protein localization
GO:0007472--P:wing disc morphogenesis

KEGG

dme:Dmel_CG2944

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002040	Ailuropoda melanoleuca	69.68	1.00e-115	408.00
IUUC-Apl-004008	Anas platyrhynchos	68.95	1.00e-114	405.00
IUUC-Aca-004723	Anolis carolinensis	71.84	3.00e-118	416.00
IUUC-Ame-010841	Astyanax mexicanus	69.68	2.00e-115	407.00
IUUC-Bta-012816	Bos taurus	69.68	9.00e-116	408.00
IUUC-Cel-018566	Caenorhabditis elegans	56.73	1.00e-81	296.00
IUUC-Cja-019531	Callithrix jacchus	70.04	6.00e-116	409.00
IUUC-Cfa-020107	Canis familiaris	69.68	1.00e-115	407.00
IUUC-Cpo-021983	Cavia porcellus	69.68	4.00e-115	406.00
IUUC-Cre-022682	Chlamydomonas reinhardtii	31.58	3.00e-03	32.30
IUUC-Csa-023603	Chlorocebus sabaeus	70.04	5.00e-116	409.00
IUUC-Cho-024458	Choloepus hoffmanni	64.86	1.00e-51	195.00
IUUC-Cin-025737	Ciona intestinalis	59.26	3.00e-89	320.00
IUUC-Csv-026238	Ciona savignyi	59.43	5.00e-88	316.00
IUUC-Dre-028699	Danio rerio	70.40	7.00e-116	409.00
IUUC-Dno-028959	Dasypus novemcinctus	70.66	4.00e-111	392.00
IUUC-Dor-030400	Dipodomys ordii	69.68	3.00e-115	406.00
IUUC-Ete-033077	Echinops telfairi	66.30	1.00e-107	381.00
IUUC-Eca-034017	Equus caballus	70.04	6.00e-116	409.00
IUUC-Eeu-035331	Erinaceus europaeus	68.12	4.00e-114	403.00
IUUC-Fca-035981	Felis catus	69.68	1.00e-115	407.00
IUUC-Fal-036622	Ficedula albicollis	72.92	1.00e-119	421.00
IUUC-Fox-037964	Fusarium oxysporum	29.17	6.00e-03	35.00
IUUC-Gmo-038808	Gadus morhua	65.12	8.00e-105	372.00
IUUC-Gga-040436	Gallus gallus	73.29	6.00e-120	422.00
IUUC-Gac-041392	Gasterosteus aculeatus	66.43	2.00e-109	387.00
IUUC-Ggo-044990	Gorilla gorilla	70.04	6.00e-116	409.00
IUUC-Hsa-045783	Homo sapiens	70.40	2.00e-116	410.00
IUUC-Itr-048565	Ictidomys tridecemlineatus	71.65	1.00e-110	391.00
IUUC-Lch-050022	Latimeria chalumnae	74.16	1.00e-109	388.00
IUUC-Loc-051943	Lepisosteus oculatus	72.92	5.00e-119	419.00
IUUC-Laf-053976	Loxodonta africana	70.93	1.00e-110	391.00
IUUC-Mcc-055223	Macaca mulatta	70.04	6.00e-116	409.00
IUUC-Meu-056163	Macropus eugenii	71.12	3.00e-117	413.00
IUUC-Mtr-058202	Medicago truncatula	36.67	7.90e-02	29.30
IUUC-Mga-059620	Meleagris gallopavo	68.12	1.00e-114	404.00
IUUC-Mmr-061373	Microcebus murinus	69.31	5.00e-115	405.00
IUUC-Mdo-062070	Monodelphis domestica	70.76	1.00e-116	410.00
IUUC-Mmu-064370	Mus musculus	69.68	4.00e-115	406.00
IUUC-Mpu-066516	Mustela putorius furo	69.31	2.00e-115	407.00
IUUC-Mlu-067789	Myotis lucifugus	67.22	6.00e-96	342.00
IUUC-Nle-069241	Nomascus leucogenys	67.87	6.00e-110	389.00
IUUC-Opr-070732	Ochotona princeps	69.31	7.00e-115	405.00
IUUC-Ont-071823	Oreochromis niloticus	66.19	9.00e-103	365.00
IUUC-Oan-072734	Ornithorhynchus anatinus	71.48	4.00e-117	412.00
IUUC-Ocu-074726	Oryctolagus cuniculus	69.31	4.00e-114	402.00
IUUC-Ogl-077420	Oryza glaberrima	41.18	6.00e-02	31.60
IUUC-Ola-087207	Oryzias latipes	66.31	1.00e-101	361.00
IUUC-Oga-089174	Otolemur garnettii	70.04	1.00e-116	411.00
IUUC-Oar-089518	Ovis aries	70.04	7.00e-116	409.00
IUUC-Ptr-090932	Pan troglodytes	70.04	6.00e-116	409.00
IUUC-Pan-091876	Papio anubis	70.04	6.00e-116	409.00
IUUC-Psi-093552	Pelodiscus sinensis	71.84	2.00e-118	417.00
IUUC-Pma-094441	Petromyzon marinus	50.72	1.00e-76	278.00
IUUC-Pfo-096646	Poecilia formosa	66.90	2.00e-104	370.00
IUUC-Pab-098256	Pongo abelii	68.23	2.00e-110	391.00
IUUC-Pca-100140	Procavia capensis	70.94	5.00e-99	352.00
IUUC-Pva-102977	Pteropus vampyrus	70.04	6.00e-116	409.00
IUUC-Rno-105030	Rattus norvegicus	69.68	3.00e-115	407.00
IUUC-Sha-107522	Sarcophilus harrisii	70.76	2.00e-116	410.00
IUUC-Sit-110638	Setaria italica	26.42	4.40e-02	31.60
IUUC-Sar-113664	Sorex araneus	67.51	5.00e-109	386.00
IUUC-Sre-114972	Sporisorium reilianum	44.12	7.70e-02	30.40
IUUC-Ssc-115430	Sus scrofa	67.15	7.00e-109	385.00
IUUC-Tgu-116552	Taeniopygia guttata	73.29	5.00e-120	422.00
IUUC-Tru-118256	Takifugu rubripes	66.06	4.00e-110	389.00
IUUC-Tsy-119192	Tarsius syrichta	69.66	8.00e-95	338.00
IUUC-Tni-120160	Tetraodon nigroviridis	66.79	9.00e-99	352.00
IUUC-Tae-124746	Triticum aestivum	50.00	2.70e-02	33.10
IUUC-Tbe-127668	Tupaia belangeri	71.79	8.00e-101	358.00
IUUC-Ttr-128238	Tursiops truncatus	67.51	2.00e-108	384.00
IUUC-Xtr-132803	Xenopus tropicalis	69.57	1.00e-115	407.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence