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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046057
UUCD1 version UUC-HoS-00803
Ensembl Protein ID ENSP00000393154.2
UniProt Accession Q8NCQ5; B3KST3; FBX15_HUMAN
Genbank Protein ID BAG52845.1; EAW66537.1; AAH29579.1
Protein Name F-box only protein 15
Genbank Nucleotide ID AK094215; CH471117; BC029579
Gene Name FBXO15; FBX15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141665.11 ENST00000419743.6 ENSP00000393154.2
ENSG00000141665.11 ENST00000581214.5 ENSP00000462143.1
ENSG00000141665.11 ENST00000580088.1 ENSP00000462117.1
ENSG00000141665.11 ENST00000578399.5 ENSP00000462151.1
ENSG00000141665.11 ENST00000579517.2 ENSP00000463247.2
ENSG00000141665.11 ENST00000585174.5 ENSP00000463378.1
ENSG00000141665.11 ENST00000582526.1 ENSP00000463529.1
ENSG00000141665.11 ENST00000580552.1 ENSP00000462361.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsiteCircNetmicroRNA
TRANSFACRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 23465077
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0059 18.3 71 115
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelasqkalwk 144
           +g ld +p eil++i+++ld+ +ll   +v+rr+++la+++ +w 
   Q: 71   SGFLDGMPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWI 115
           5678899*****************************999898886 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Protein Sequence
(Fasta)
MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS AALRCHAGGG 60
QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV SRRFYHLAND NFIWIGIYST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046057|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGACGTGC GGGCGTGGGG GCGGTGCGTG CACTCTTCGT TTCAGCCCTG GCGCGGTCCT 60
GTGGTGAACT CCTTGTCTCT ATGGCGACTG GACGCGGTCG GATCTTGCAG CAGCACTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046057|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
KEGG hsa:201456
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000647 Aegilops tauschii 21.43 1.00e-03 38.10
IUUC-Aml-002405 Ailuropoda melanoleuca 79.48 0.00e+00 760.00
IUUC-Apl-003324 Anas platyrhynchos 55.48 2.00e-150 525.00
IUUC-Aca-005125 Anolis carolinensis 47.63 4.00e-124 438.00
IUUC-Ame-011048 Astyanax mexicanus 34.98 4.00e-84 305.00
IUUC-Bta-012411 Bos taurus 67.96 0.00e+00 670.00
IUUC-Cja-019553 Callithrix jacchus 93.32 0.00e+00 841.00
IUUC-Cfa-020889 Canis familiaris 74.36 0.00e+00 760.00
IUUC-Cpo-021751 Cavia porcellus 78.11 0.00e+00 717.00
IUUC-Csa-023731 Chlorocebus sabaeus 95.16 0.00e+00 863.00
IUUC-Cho-025085 Choloepus hoffmanni 70.43 4.00e-141 494.00
IUUC-Dre-028738 Danio rerio 33.18 8.00e-71 261.00
IUUC-Dno-029151 Dasypus novemcinctus 72.25 0.00e+00 710.00
IUUC-Dor-030689 Dipodomys ordii 70.74 2.00e-177 615.00
IUUC-Ete-032332 Echinops telfairi 40.82 1.00e-56 214.00
IUUC-Eca-033940 Equus caballus 83.87 0.00e+00 769.00
IUUC-Eeu-034892 Erinaceus europaeus 65.17 9.00e-26 111.00
IUUC-Fca-035716 Felis catus 75.91 0.00e+00 707.00
IUUC-Fal-037500 Ficedula albicollis 53.30 4.00e-143 501.00
IUUC-Gmo-038658 Gadus morhua 40.39 5.00e-39 155.00
IUUC-Gga-040217 Gallus gallus 52.85 1.00e-142 499.00
IUUC-Gac-041425 Gasterosteus aculeatus 34.51 9.00e-75 274.00
IUUC-Ggo-045655 Gorilla gorilla 98.93 0.00e+00 954.00
IUUC-Itr-047920 Ictidomys tridecemlineatus 79.18 0.00e+00 754.00
IUUC-Lch-049438 Latimeria chalumnae 46.76 1.00e-126 446.00
IUUC-Loc-052282 Lepisosteus oculatus 36.19 9.00e-89 320.00
IUUC-Laf-054553 Loxodonta africana 75.58 0.00e+00 706.00
IUUC-Mcc-054623 Macaca mulatta 94.31 0.00e+00 956.00
IUUC-Meu-056389 Macropus eugenii 53.00 1.00e-118 419.00
IUUC-Mtr-058175 Medicago truncatula 42.86 1.00e-05 44.30
IUUC-Mga-060054 Meleagris gallopavo 51.37 4.00e-107 381.00
IUUC-Mmr-061587 Microcebus murinus 77.12 0.00e+00 768.00
IUUC-Mdo-062766 Monodelphis domestica 67.41 0.00e+00 647.00
IUUC-Mmu-063245 Mus musculus 56.90 8.00e-154 536.00
IUUC-Mpu-065732 Mustela putorius furo 72.45 0.00e+00 730.00
IUUC-Mlu-068036 Myotis lucifugus 72.99 0.00e+00 770.00
IUUC-Nle-069296 Nomascus leucogenys 95.29 0.00e+00 952.00
IUUC-Opr-070759 Ochotona princeps 77.19 8.00e-104 370.00
IUUC-Ont-071264 Oreochromis niloticus 35.93 2.00e-78 286.00
IUUC-Oan-072880 Ornithorhynchus anatinus 48.66 1.00e-104 372.00
IUUC-Ocu-074765 Oryctolagus cuniculus 74.08 0.00e+00 664.00
IUUC-Oni-082278 Oryza nivara 31.82 1.30e-02 33.90
IUUC-Opu-083767 Oryza punctata 31.82 7.00e-03 34.70
IUUC-Ola-087153 Oryzias latipes 34.58 2.00e-61 229.00
IUUC-Oga-088288 Otolemur garnettii 79.72 0.00e+00 738.00
IUUC-Oar-089451 Ovis aries 64.95 2.00e-176 612.00
IUUC-Ptr-090512 Pan troglodytes 99.05 0.00e+00 834.00
IUUC-Pan-091693 Papio anubis 93.92 0.00e+00 941.00
IUUC-Psi-093993 Pelodiscus sinensis 55.28 2.00e-165 575.00
IUUC-Ppa-095293 Physcomitrella patens 30.23 3.00e-04 40.40
IUUC-Pfo-097267 Poecilia formosa 35.52 2.00e-79 290.00
IUUC-Pab-098508 Pongo abelii 97.00 0.00e+00 877.00
IUUC-Pca-101129 Procavia capensis 60.94 8.00e-110 390.00
IUUC-Pva-102264 Pteropus vampyrus 75.29 0.00e+00 659.00
IUUC-Rno-105859 Rattus norvegicus 72.25 0.00e+00 689.00
IUUC-Sar-113536 Sorex araneus 62.41 2.00e-157 548.00
IUUC-Ssc-115961 Sus scrofa 79.00 1.00e-177 615.00
IUUC-Tgu-117170 Taeniopygia guttata 51.95 4.00e-138 484.00
IUUC-Tsy-119594 Tarsius syrichta 67.28 2.00e-160 558.00
IUUC-Tni-120176 Tetraodon nigroviridis 33.87 4.00e-60 225.00
IUUC-Tvi-122264 Trichoderma virens 46.94 7.00e-07 49.30
IUUC-Tme-126943 Tuber melanosporum 28.30 6.00e-05 43.90
IUUC-Tbe-127546 Tupaia belangeri 73.27 0.00e+00 655.00
IUUC-Ttr-128414 Tursiops truncatus 77.14 0.00e+00 662.00
IUUC-Xtr-132270 Xenopus tropicalis 45.70 6.00e-113 401.00
Created Date 25-Jun-2017

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