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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045913
Ensembl Protein ID ENSP00000468647.1
UniProt Accession Q9HCJ0; G3XAB8; Q86UE5; Q8N3D8; Q96MU9; TNR6C_HUMAN
Genbank Protein ID BAB13408.2; EAW89480.1; CAD39090.1; AAH45631.1; BAB71179.1
Protein Name Trinucleotide repeat-containing gene 6C protein
Genbank Nucleotide ID AB046802; AC021593; AL834429; BC045631; AK056421
Gene Name TNRC6C; KIAA1582
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078687.17 ENST00000636222.1 ENSP00000489933.1
ENSG00000078687.17 ENST00000588847.5 ENSP00000467154.1
ENSG00000078687.17 ENST00000588061.5 ENSP00000468647.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 41.84 1.00e-35 149.00 IUUC-Dme-032014
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
 Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Protein Sequence
(Fasta)
MATGSAQGNF TGHTKKTNGN NGTNGALVQS PSNQSALGAG GANSNGSAAR VWGVATGSSS 60
GLAHCSVSGG DGKMDTMIGD GRSQNCWGAS NSNAGINLNL NPNANPAAWP VLGHEGTVAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045913|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCGCCGCCGC CGCCGGGGAC GGAGCCCAGG TGAGCGCGGC AGTCCGCCCG CTCCTCGCCG 60
CAGCCGCAAC TTTGCCGGGA GGTTCGCGGG CCCTTTGTTC GGCCGAGCCG AGCCGGGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045913|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0810--Translation regulation
Interpro

IPR019486--Argonaute_hook_dom
IPR026805--GW182_M_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR032226--TNRC6_PABC-bd
IPR033499--TNRC6C
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50030--UBA
Pfam

PF10427--Ago_hook
PF12938--M_domain
PF00076--RRM_1
PF16608--TNRC6-PABC_bdg
PF00627--UBA
SMART

SM00165--UBA
Gene Ontology

GO:0005829--C:cytosol
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0035195--P:gene silencing by miRNA
GO:0035278--P:miRNA mediated inhibition of translation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:1900153--P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0060213--P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0035194--P:posttranscriptional gene silencing by RNA
GO:0007223--P:Wnt signaling pathway, calcium modulating pathway
KEGG hsa:57690
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001985 Ailuropoda melanoleuca 41.55 0.00e+00 748.00
IUUC-Apl-003191 Anas platyrhynchos 84.39 0.00e+00 2174.00
IUUC-Aca-004717 Anolis carolinensis 84.41 0.00e+00 2196.00
IUUC-Ame-010681 Astyanax mexicanus 51.13 0.00e+00 810.00
IUUC-Bta-012915 Bos taurus 36.37 1.00e-99 359.00
IUUC-Cja-019614 Callithrix jacchus 96.95 0.00e+00 2379.00
IUUC-Cfa-020452 Canis familiaris 36.05 2.00e-100 361.00
IUUC-Cpo-021452 Cavia porcellus 90.65 0.00e+00 2330.00
IUUC-Csa-023169 Chlorocebus sabaeus 41.56 0.00e+00 734.00
IUUC-Cho-024655 Choloepus hoffmanni 39.90 3.00e-119 424.00
IUUC-Dre-028059 Danio rerio 57.43 0.00e+00 1061.00
IUUC-Dno-029734 Dasypus novemcinctus 40.22 0.00e+00 711.00
IUUC-Dor-030671 Dipodomys ordii 42.34 0.00e+00 630.00
IUUC-Dme-032014 Drosophila melanogaster 40.00 1.00e-30 129.00
IUUC-Ete-032774 Echinops telfairi 82.41 0.00e+00 1481.00
IUUC-Eca-033866 Equus caballus 91.13 0.00e+00 2216.00
IUUC-Eeu-034572 Erinaceus europaeus 55.09 6.00e-40 160.00
IUUC-Fal-036856 Ficedula albicollis 83.25 0.00e+00 2024.00
IUUC-Gga-040531 Gallus gallus 88.29 0.00e+00 2161.00
IUUC-Gac-041681 Gasterosteus aculeatus 53.03 0.00e+00 881.00
IUUC-Ggo-045143 Gorilla gorilla 97.91 0.00e+00 2444.00
IUUC-Lch-049619 Latimeria chalumnae 49.38 2.00e-96 348.00
IUUC-Loc-052289 Lepisosteus oculatus 70.79 0.00e+00 1063.00
IUUC-Laf-053607 Loxodonta africana 90.40 0.00e+00 2301.00
IUUC-Mcc-055342 Macaca mulatta 98.80 0.00e+00 2367.00
IUUC-Meu-056275 Macropus eugenii 47.83 1.00e-95 345.00
IUUC-Mtr-058185 Medicago truncatula 44.44 2.00e-03 38.10
IUUC-Mga-059241 Meleagris gallopavo 38.59 1.00e-112 402.00
IUUC-Mmr-061348 Microcebus murinus 35.76 4.00e-95 344.00
IUUC-Mdo-062155 Monodelphis domestica 86.13 0.00e+00 2229.00
IUUC-Mmu-064259 Mus musculus 43.36 0.00e+00 718.00
IUUC-Mpu-066534 Mustela putorius furo 50.51 6.00e-80 293.00
IUUC-Mlu-067834 Myotis lucifugus 39.89 0.00e+00 738.00
IUUC-Nle-069168 Nomascus leucogenys 41.04 0.00e+00 712.00
IUUC-Opr-070976 Ochotona princeps 34.77 1.00e-77 286.00
IUUC-Ocu-074534 Oryctolagus cuniculus 74.81 0.00e+00 782.00
IUUC-Oga-088116 Otolemur garnettii 40.18 0.00e+00 713.00
IUUC-Oar-090041 Ovis aries 36.07 3.00e-98 354.00
IUUC-Ptr-091135 Pan troglodytes 96.90 0.00e+00 2367.00
IUUC-Pan-092665 Papio anubis 96.31 0.00e+00 2336.00
IUUC-Psi-093057 Pelodiscus sinensis 85.70 0.00e+00 2160.00
IUUC-Pma-094508 Petromyzon marinus 55.06 3.00e-54 206.00
IUUC-Pfo-097115 Poecilia formosa 53.80 0.00e+00 649.00
IUUC-Pab-097935 Pongo abelii 44.75 2.00e-129 457.00
IUUC-Pca-100481 Procavia capensis 78.27 0.00e+00 1256.00
IUUC-Pva-102376 Pteropus vampyrus 35.58 2.00e-70 262.00
IUUC-Rno-105508 Rattus norvegicus 39.45 4.00e-95 343.00
IUUC-Sar-113036 Sorex araneus 60.48 7.00e-41 163.00
IUUC-Sbi-114163 Sorghum bicolor 30.88 1.60e-01 31.60
IUUC-Ssc-115574 Sus scrofa 71.60 0.00e+00 1501.00
IUUC-Tgu-117233 Taeniopygia guttata 87.65 0.00e+00 2092.00
IUUC-Tru-117725 Takifugu rubripes 54.88 0.00e+00 971.00
IUUC-Tsy-118786 Tarsius syrichta 36.26 5.00e-69 257.00
IUUC-Tae-123684 Triticum aestivum 37.93 7.20e-02 32.30
IUUC-Tbe-127989 Tupaia belangeri 84.29 0.00e+00 904.00
IUUC-Ttr-128518 Tursiops truncatus 91.19 0.00e+00 2316.00
IUUC-Vpa-130230 Vicugna pacos 43.50 1.00e-73 272.00
IUUC-Xtr-132265 Xenopus tropicalis 73.87 0.00e+00 1796.00
Created Date 25-Jun-2017

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