iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15280365
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	11001934; 12095988; 15280365; 18079109; 19249996

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	4.30e-10	41.1	559	596
ULD/UDP/UBQ/UBQ_PIM	3.60e-22	79.8	13	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 559  FQQQLEQLNSMGFiNREANLQALIATGGDINAAIERLL 596
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +++tvkt+k+ke e+ +    +v+e+Ke+i+++++ +++q+ LI+aGkiLkD +tL+++gikdg +vhlv+k+++
   Q: 13   IRVTVKTPKDKE-EIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQ 86
           68**********.***********************************************************987 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).

Protein Sequence
(Fasta)

MAEPSGAETR PPIRVTVKTP KDKEEIVICD RASVKEFKEE ISRRFKAQQD QLVLIFAGKI 60
LKDGDTLNQH GIKDGLTVHL VIKTPQKAQD PAAATASSPS TPDPASAPST TPASPATPAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGAGGCG CAGAAGCCGA GCCGGGCCGG CCGGGCGGGC GGGGAGGAGG AGGAGCCGGG 60
CGGGCTGGCG GGCGGCCGGG TGGCGGCGGC GGCATGGCGG AGCCGAGCGG GGCCGAGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0006914--P:autophagy
GO:1901097--P:negative regulation of autophagosome maturation
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

hsa:56893

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001730	Ailuropoda melanoleuca	87.91	6.00e-158	550.00
IUUC-Apl-004150	Anas platyrhynchos	87.76	3.00e-159	555.00
IUUC-Ath-007271	Arabidopsis thaliana	39.05	5.00e-43	169.00
IUUC-Ani-009418	Aspergillus nidulans	38.10	6.00e-08	52.00
IUUC-Ame-011329	Astyanax mexicanus	71.13	6.00e-168	584.00
IUUC-Bta-012938	Bos taurus	96.71	1.00e-164	573.00
IUUC-Bdi-014265	Brachypodium distachyon	33.72	3.00e-49	189.00
IUUC-Cja-018858	Callithrix jacchus	99.33	1.00e-174	606.00
IUUC-Cfa-020455	Canis familiaris	96.24	3.00e-168	585.00
IUUC-Cpo-021410	Cavia porcellus	94.13	1.00e-162	566.00
IUUC-Dre-028009	Danio rerio	75.76	1.00e-150	526.00
IUUC-Dno-029892	Dasypus novemcinctus	98.12	8.00e-163	567.00
IUUC-Eca-034284	Equus caballus	98.83	1.00e-169	589.00
IUUC-Fca-036145	Felis catus	81.12	9.00e-125	440.00
IUUC-Fal-037180	Ficedula albicollis	88.24	1.00e-157	550.00
IUUC-Fox-037726	Fusarium oxysporum	50.00	9.00e-07	48.50
IUUC-Gmo-039317	Gadus morhua	70.75	4.00e-146	511.00
IUUC-Gga-041050	Gallus gallus	88.00	3.00e-150	525.00
IUUC-Gac-041826	Gasterosteus aculeatus	71.40	2.00e-149	522.00
IUUC-Ggo-044680	Gorilla gorilla	99.77	2.00e-170	592.00
IUUC-Itr-048781	Ictidomys tridecemlineatus	96.95	1.00e-168	586.00
IUUC-Lch-049480	Latimeria chalumnae	74.71	3.00e-140	492.00
IUUC-Loc-051845	Lepisosteus oculatus	72.87	2.00e-137	482.00
IUUC-Laf-054476	Loxodonta africana	98.36	3.00e-173	601.00
IUUC-Mcc-054765	Macaca mulatta	99.77	6.00e-171	594.00
IUUC-Meu-056843	Macropus eugenii	91.44	3.00e-166	578.00
IUUC-Mor-057194	Magnaporthe oryzae	50.00	3.00e-07	49.70
IUUC-Mpo-057467	Magnaporthe poae	50.00	4.00e-07	47.00
IUUC-Mla-058987	Melampsora laricipopulina	53.49	4.00e-07	49.30
IUUC-Mga-059730	Meleagris gallopavo	88.00	4.00e-157	548.00
IUUC-Mvi-060466	Microbotryum violaceum	54.76	3.00e-08	53.10
IUUC-Mmr-061256	Microcebus murinus	98.59	6.00e-179	620.00
IUUC-Mdo-061917	Monodelphis domestica	90.33	9.00e-167	580.00
IUUC-Mmu-063397	Mus musculus	94.84	1.00e-176	613.00
IUUC-Mpu-066300	Mustela putorius furo	96.00	1.00e-173	603.00
IUUC-Mlu-067197	Myotis lucifugus	94.60	5.00e-163	567.00
IUUC-Nfi-068487	Neosartorya fischeri	35.71	3.00e-08	53.50
IUUC-Ncr-068732	Neurospora crassa	50.00	2.00e-07	50.10
IUUC-Opr-070323	Ochotona princeps	94.61	2.00e-169	588.00
IUUC-Ont-072038	Oreochromis niloticus	74.76	5.00e-151	528.00
IUUC-Ocu-074759	Oryctolagus cuniculus	97.89	4.00e-163	568.00
IUUC-Ola-086802	Oryzias latipes	67.64	1.00e-144	506.00
IUUC-Oga-088466	Otolemur garnettii	97.42	5.00e-166	578.00
IUUC-Oar-090375	Ovis aries	96.71	9.00e-164	570.00
IUUC-Ptr-091312	Pan troglodytes	99.77	6.00e-171	594.00
IUUC-Pan-092351	Papio anubis	99.77	6.00e-171	594.00
IUUC-Psi-093262	Pelodiscus sinensis	87.32	0.00e+00	661.00
IUUC-Pab-097627	Pongo abelii	96.48	1.00e-169	590.00
IUUC-Pca-100181	Procavia capensis	93.02	2.00e-103	369.00
IUUC-Pva-102687	Pteropus vampyrus	83.80	2.00e-136	479.00
IUUC-Rno-105804	Rattus norvegicus	90.68	0.00e+00	742.00
IUUC-Sha-107346	Sarcophilus harrisii	89.98	1.00e-164	573.00
IUUC-Ssl-108425	Sclerotinia sclerotiorum	50.00	7.00e-07	48.10
IUUC-Smo-109502	Selaginella moellendorffii	31.18	9.00e-39	154.00
IUUC-Sly-111731	Solanum lycopersicum	55.37	3.00e-36	146.00
IUUC-Stu-112263	Solanum tuberosum	55.37	3.00e-36	146.00
IUUC-Ssc-116185	Sus scrofa	99.06	5.00e-165	574.00
IUUC-Tgu-116930	Taeniopygia guttata	88.00	4.00e-156	544.00
IUUC-Tru-118652	Takifugu rubripes	73.89	6.00e-148	517.00
IUUC-Tsy-118798	Tarsius syrichta	98.34	3.00e-99	354.00
IUUC-Tre-122085	Trichoderma reesei	48.84	4.00e-07	49.30
IUUC-Tvi-122381	Trichoderma virens	47.73	7.00e-07	48.50
IUUC-Ttr-128771	Tursiops truncatus	98.59	2.00e-171	595.00
IUUC-Vpa-130633	Vicugna pacos	78.54	1.00e-105	376.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence