iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167196.13	ENST00000308275.7	ENSP00000307833.3
ENSG00000167196.13	ENST00000453211.6	ENSP00000396442.2
ENSG00000167196.13	ENST00000565036.5	ENSP00000457177.1
ENSG00000167196.13	ENST00000561885.1	ENSP00000458022.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21768309; 23333857

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.073	14.8	27	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 108  eeilveilklldkeellraarvcrrwqelasq 139
            e++ ++l++l+++ llr+a+vcr w+e+ ++
   Q: 27   AEVVERVLTFLPAKALLRVACVCRLWRECVRR 58
           5899***********************99883 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Protein Sequence
(Fasta)

MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR LWRECVRRVL 60
RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH TVLYMADSET FISLEECRGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCGCGGA CGCCTGCTCA GTGCGCGCCG GCCGGGCAAC CCTATGCTGG CGTAATCGGG 60
TTCCTCCGAG CCGCCGTAGG ACTGGTTCCG GCGGGCTGGT GAGGAATGGA GCCGGTAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR019494--FIST_C

Pfam

PF00646--F-box
PF10442--FIST_C

SMART

SM01204--FIST_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0009267--P:cellular response to starvation
GO:0006913--P:nucleocytoplasmic transport
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:26263

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001386	Ailuropoda melanoleuca	93.35	0.00e+00	758.00
IUUC-Atr-002780	Amborella trichopoda	50.00	7.00e-07	48.90
IUUC-Apl-004192	Anas platyrhynchos	68.69	3.00e-128	451.00
IUUC-Aca-004748	Anolis carolinensis	86.11	2.00e-16	76.60
IUUC-Aor-010231	Aspergillus oryzae	36.11	1.70e-01	31.20
IUUC-Ame-010876	Astyanax mexicanus	52.26	1.00e-64	239.00
IUUC-Bta-013288	Bos taurus	89.95	0.00e+00	721.00
IUUC-Bol-016158	Brassica oleracea	36.36	8.00e-04	39.70
IUUC-Bra-017851	Brassica rapa	43.59	6.00e-04	38.90
IUUC-Cja-019337	Callithrix jacchus	96.90	0.00e+00	775.00
IUUC-Cfa-020236	Canis familiaris	88.09	0.00e+00	732.00
IUUC-Cpo-021841	Cavia porcellus	84.00	9.00e-180	622.00
IUUC-Cre-022684	Chlamydomonas reinhardtii	41.86	1.20e-01	31.20
IUUC-Csa-023548	Chlorocebus sabaeus	91.25	0.00e+00	778.00
IUUC-Cho-024526	Choloepus hoffmanni	82.96	8.00e-176	609.00
IUUC-Dre-028434	Danio rerio	49.87	6.00e-100	357.00
IUUC-Dno-030026	Dasypus novemcinctus	93.00	0.00e+00	759.00
IUUC-Ete-032223	Echinops telfairi	89.86	4.00e-73	268.00
IUUC-Eca-033274	Equus caballus	92.42	0.00e+00	686.00
IUUC-Eeu-035160	Erinaceus europaeus	64.11	1.00e-88	319.00
IUUC-Fca-036405	Felis catus	93.81	0.00e+00	756.00
IUUC-Fal-037025	Ficedula albicollis	68.22	4.00e-158	550.00
IUUC-Gmo-038877	Gadus morhua	50.26	1.00e-106	379.00
IUUC-Gga-041274	Gallus gallus	67.70	4.00e-155	540.00
IUUC-Gac-042032	Gasterosteus aculeatus	51.30	1.00e-108	386.00
IUUC-Gma-044381	Glycine max	41.86	4.00e-04	40.00
IUUC-Ggo-045390	Gorilla gorilla	99.50	0.00e+00	825.00
IUUC-Hvu-047063	Hordeum vulgare	30.61	4.00e-03	36.20
IUUC-Itr-048696	Ictidomys tridecemlineatus	94.31	0.00e+00	783.00
IUUC-Lch-049717	Latimeria chalumnae	59.59	1.00e-130	459.00
IUUC-Lpe-051707	Leersia perrieri	61.54	1.00e-03	37.70
IUUC-Loc-052463	Lepisosteus oculatus	55.98	1.00e-125	443.00
IUUC-Laf-054467	Loxodonta africana	93.85	0.00e+00	755.00
IUUC-Mcc-055596	Macaca mulatta	99.04	0.00e+00	637.00
IUUC-Mpo-057515	Magnaporthe poae	42.86	4.60e-02	30.00
IUUC-Mtr-058238	Medicago truncatula	30.77	6.00e-04	39.30
IUUC-Mga-059974	Meleagris gallopavo	68.27	7.00e-127	446.00
IUUC-Mmr-061349	Microcebus murinus	92.33	0.00e+00	764.00
IUUC-Mdo-062898	Monodelphis domestica	67.48	2.00e-160	558.00
IUUC-Mmu-063154	Mus musculus	92.31	0.00e+00	763.00
IUUC-Mpu-066283	Mustela putorius furo	92.58	0.00e+00	753.00
IUUC-Mlu-067324	Myotis lucifugus	78.21	2.00e-136	478.00
IUUC-Nle-069629	Nomascus leucogenys	99.01	0.00e+00	820.00
IUUC-Opr-071177	Ochotona princeps	84.95	0.00e+00	666.00
IUUC-Ont-072531	Oreochromis niloticus	50.13	2.00e-108	385.00
IUUC-Oan-072774	Ornithorhynchus anatinus	66.56	6.00e-115	407.00
IUUC-Ocu-074384	Oryctolagus cuniculus	86.60	0.00e+00	647.00
IUUC-Oba-075218	Oryza barthii	31.67	6.90e-02	34.30
IUUC-Olo-080717	Oryza longistaminata	40.48	3.30e-02	34.30
IUUC-Ome-081396	Oryza meridionalis	34.88	2.00e-03	37.40
IUUC-Oni-082080	Oryza nivara	33.33	1.40e-02	36.60
IUUC-Oru-085179	Oryza rufipogon	40.48	5.50e-02	34.70
IUUC-Ola-086930	Oryzias latipes	50.78	2.00e-107	382.00
IUUC-Oga-087924	Otolemur garnettii	92.82	0.00e+00	776.00
IUUC-Oar-089765	Ovis aries	88.66	0.00e+00	712.00
IUUC-Ptr-090695	Pan troglodytes	99.50	0.00e+00	826.00
IUUC-Pan-092209	Papio anubis	97.28	0.00e+00	804.00
IUUC-Psi-093751	Pelodiscus sinensis	67.09	3.00e-155	541.00
IUUC-Pno-094786	Phaeosphaeria nodorum	36.36	2.10e-02	33.10
IUUC-Ppa-095563	Physcomitrella patens	55.56	2.00e-03	37.40
IUUC-Pfo-097170	Poecilia formosa	50.26	2.00e-108	385.00
IUUC-Pab-098587	Pongo abelii	98.76	0.00e+00	819.00
IUUC-Pop-099427	Populus trichocarpa	36.59	9.00e-06	45.10
IUUC-Pca-100536	Procavia capensis	80.65	2.00e-148	518.00
IUUC-Ppe-101327	Prunus persica	52.27	2.00e-06	47.80
IUUC-Pva-102535	Pteropus vampyrus	88.33	0.00e+00	651.00
IUUC-Rno-105972	Rattus norvegicus	92.06	0.00e+00	761.00
IUUC-Sha-106865	Sarcophilus harrisii	64.07	3.00e-145	508.00
IUUC-Sly-111465	Solanum lycopersicum	41.82	3.00e-04	40.00
IUUC-Stu-112413	Solanum tuberosum	47.73	1.00e-04	41.60
IUUC-Sar-113081	Sorex araneus	90.00	4.00e-168	583.00
IUUC-Sbi-114741	Sorghum bicolor	40.91	5.20e-02	33.50
IUUC-Ssc-115861	Sus scrofa	88.48	6.00e-112	396.00
IUUC-Tgu-117324	Taeniopygia guttata	68.75	2.00e-157	548.00
IUUC-Tru-118740	Takifugu rubripes	48.96	8.00e-98	350.00
IUUC-Tsy-118948	Tarsius syrichta	95.83	0.00e+00	751.00
IUUC-Tni-120182	Tetraodon nigroviridis	46.84	4.00e-97	348.00
IUUC-Tca-121806	Theobroma cacao	36.49	2.00e-05	44.30
IUUC-Tae-124206	Triticum aestivum	42.86	6.00e-03	35.40
IUUC-Tur-126607	Triticum urartu	32.65	1.00e-03	38.10
IUUC-Tbe-127382	Tupaia belangeri	85.64	0.00e+00	647.00
IUUC-Ttr-128894	Tursiops truncatus	94.82	5.00e-107	380.00
IUUC-Vpa-130065	Vicugna pacos	92.03	2.00e-74	272.00
IUUC-Vvi-130950	Vitis vinifera	29.87	3.00e-04	40.00
IUUC-Xtr-131922	Xenopus tropicalis	53.00	7.00e-115	407.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence