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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047002
UUCD1 version UUC-HoS-00433
Ensembl Protein ID ENSP00000265651.3
UniProt Accession Q9UK99; B3KY16; D3DR05; Q86X90; Q9H0V2; Q9NUX2; FBX3_HUMAN
Genbank Protein ID BAA91991.1; BAG54678.1; CAB66560.1; EAW68186.1; EAW68188.1; EAW68189.1; AAH46110.1; AAF03702.1
Protein Name F-box only protein 3
Genbank Nucleotide ID AK001943; AK128454; AL136625; AC113192; CH471064; CH471064; BC046110; AF176702
Gene Name FBXO3; FBX3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110429.13 ENST00000265651.7 ENSP00000265651.3
ENSG00000110429.13 ENST00000530401.5 ENSP00000433781.1
ENSG00000110429.13 ENST00000534136.5 ENSP00000431745.1
ENSG00000110429.13 ENST00000448981.6 ENSP00000408836.2
ENSG00000110429.13 ENST00000532927.5 ENSP00000434099.1
ENSG00000110429.13 ENST00000529137.1 ENSP00000431502.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18809579
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.046 15.4 7 56
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 97   gpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++   +l++lp++ l+ il++ld ++l+++  v+rr+++l+s++ lw++ 
   Q: 7    ETAPLTLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRH 56
           556677899*********************************9***9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
 Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Protein Sequence
(Fasta)
MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY 60
WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047002|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGGGGCGGGG CCAGGGCGGG GCCAGACCTG CACCGGGCCA GGCAAGATGG CGGCCATGGA 60
GACCGAGACG GCGCCGCTGA CCCTAGAGTC GCTGCCCACC GATCCCCTGC TCCTCATCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047002|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007474--ApaG_domain
IPR001810--F-box_dom
IPR018958--SMI1/KNR4-like_dom
PROSITE

PS51087--APAG
PS50181--FBOX
Pfam

PF04379--DUF525
PF12937--F-box-like
PF09346--SMI1_KNR4
SMART

SM00256--FBOX
SM00860--SMI1_KNR4
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006508--P:proteolysis
KEGG hsa:26273
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001541 Ailuropoda melanoleuca 99.75 0.00e+00 785.00
IUUC-Afl-008734 Aspergillus flavus 29.69 4.00e-03 36.60
IUUC-Ani-009404 Aspergillus nidulans 29.69 3.00e-03 36.60
IUUC-Ang-009604 Aspergillus niger 31.03 9.00e-04 38.50
IUUC-Aor-009932 Aspergillus oryzae 29.69 3.00e-03 37.00
IUUC-Bta-013260 Bos taurus 98.80 0.00e+00 808.00
IUUC-Bdi-014986 Brachypodium distachyon 23.96 1.00e-13 71.20
IUUC-Bol-015263 Brassica oleracea 26.10 4.00e-20 92.80
IUUC-Cja-019627 Callithrix jacchus 99.52 0.00e+00 814.00
IUUC-Cfa-020598 Canis familiaris 99.28 0.00e+00 813.00
IUUC-Cpo-021355 Cavia porcellus 99.50 0.00e+00 783.00
IUUC-Csa-023967 Chlorocebus sabaeus 99.76 0.00e+00 816.00
IUUC-Cin-025228 Ciona intestinalis 33.75 2.00e-47 182.00
IUUC-Csv-026017 Ciona savignyi 31.11 1.00e-49 190.00
IUUC-Dno-029157 Dasypus novemcinctus 99.67 2.00e-166 578.00
IUUC-Dor-030275 Dipodomys ordii 96.86 0.00e+00 727.00
IUUC-Ete-032638 Echinops telfairi 96.65 5.00e-158 550.00
IUUC-Eca-034324 Equus caballus 96.21 0.00e+00 746.00
IUUC-Eeu-034676 Erinaceus europaeus 84.75 0.00e+00 657.00
IUUC-Fca-035703 Felis catus 99.28 0.00e+00 813.00
IUUC-Fso-038271 Fusarium solani 34.48 5.00e-05 42.70
IUUC-Ggo-044501 Gorilla gorilla 100.00 0.00e+00 817.00
IUUC-Itr-048749 Ictidomys tridecemlineatus 99.67 2.00e-166 578.00
IUUC-Laf-054310 Loxodonta africana 99.52 0.00e+00 814.00
IUUC-Mcc-055406 Macaca mulatta 99.52 0.00e+00 813.00
IUUC-Mmr-061614 Microcebus murinus 98.79 0.00e+00 801.00
IUUC-Mmu-063540 Mus musculus 95.92 0.00e+00 789.00
IUUC-Mpu-066040 Mustela putorius furo 99.28 0.00e+00 813.00
IUUC-Mlu-067763 Myotis lucifugus 94.29 0.00e+00 805.00
IUUC-Nfi-068290 Neosartorya fischeri 31.25 8.00e-04 38.90
IUUC-Nle-069186 Nomascus leucogenys 100.00 0.00e+00 817.00
IUUC-Opr-070860 Ochotona princeps 83.92 1.00e-79 290.00
IUUC-Ocu-074378 Oryctolagus cuniculus 77.50 3.00e-66 244.00
IUUC-Oba-075362 Oryza barthii 24.42 1.00e-12 67.80
IUUC-Ogl-077469 Oryza glaberrima 23.26 6.00e-12 65.90
IUUC-Oin-079080 Oryza indica 23.26 3.00e-11 63.20
IUUC-Ome-081119 Oryza meridionalis 23.68 1.00e-12 67.80
IUUC-Opu-084117 Oryza punctata 23.40 2.00e-11 63.90
IUUC-Osa-085783 Oryza sativa 23.26 3.00e-11 63.50
IUUC-Oga-088925 Otolemur garnettii 97.36 0.00e+00 799.00
IUUC-Oar-090074 Ovis aries 99.04 0.00e+00 811.00
IUUC-Ptr-091462 Pan troglodytes 100.00 0.00e+00 817.00
IUUC-Pan-092326 Papio anubis 99.52 0.00e+00 813.00
IUUC-Psi-093898 Pelodiscus sinensis 87.38 3.00e-146 511.00
IUUC-Pab-097597 Pongo abelii 100.00 0.00e+00 817.00
IUUC-Pva-102622 Pteropus vampyrus 99.28 0.00e+00 812.00
IUUC-Pte-104405 Pyrenophora teres 37.88 8.00e-04 39.70
IUUC-Rno-105168 Rattus norvegicus 96.16 0.00e+00 793.00
IUUC-Sce-106220 Saccharomyces cerevisiae 31.58 1.00e-03 38.90
IUUC-Sit-110738 Setaria italica 23.59 2.00e-08 53.50
IUUC-Stu-112725 Solanum tuberosum 34.67 1.00e-04 40.80
IUUC-Ssc-115881 Sus scrofa 99.26 3.00e-162 563.00
IUUC-Tca-121476 Theobroma cacao 26.26 4.00e-19 89.40
IUUC-Tur-126848 Triticum urartu 24.43 3.00e-13 70.10
IUUC-Ttr-128934 Tursiops truncatus 98.82 0.00e+00 704.00
IUUC-Uma-129413 Ustilago maydis 34.09 8.70e-02 33.10
IUUC-Vpa-130081 Vicugna pacos 99.74 0.00e+00 746.00
IUUC-Vvi-131081 Vitis vinifera 32.94 1.00e-04 42.00
Created Date 25-Jun-2017

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