iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143801.16	ENST00000422240.6	ENSP00000403737.2
ENSG00000143801.16	ENST00000366782.5	ENSP00000355746.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWAS Central	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	25796185

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	1.10e-07	33.3	311	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 311  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 349
           89********************************99986 PP

Organism

Homo sapiens

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Protein Sequence
(Fasta)

MLAGTVRFAR HCLKFFPAQK PACVDFGASR GRAMLTFMAS DSEEEVCDER TSLMSAESPT 60
PRSCQEGRQG PEDGENTAQW RSQENEEDGE EDPDRYVCSG VPGRPPGLEE ELTLKYGAKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTTTATGC AGAGCTCCTG GTGGCTCTGA AGCGCCCTAG GGAACAGACC AGGAACATTC 60
TCATGGTGTT AGCTCACATT GGGCCATTAG TGCTCCTTTA ATGTGAGAAC AACCGGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0026--Alzheimer disease
KW-1008--Amyloidosis
KW-0122--Cardiomyopathy
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0048013--P:ephrin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0031293--P:membrane protein intracellular domain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0001666--P:response to hypoxia

KEGG

hsa:5664

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	89.23	0.00e+00	644.00
IUUC-Apl-003959	Anas platyrhynchos	77.02	2.00e-163	568.00
IUUC-Aca-005160	Anolis carolinensis	74.35	2.00e-160	558.00
IUUC-Ang-009768	Aspergillus niger	51.85	1.40e-01	32.00
IUUC-Ame-010686	Astyanax mexicanus	79.43	3.00e-147	514.00
IUUC-Bta-013097	Bos taurus	96.66	0.00e+00	729.00
IUUC-Cja-018824	Callithrix jacchus	96.47	0.00e+00	805.00
IUUC-Cfa-020253	Canis familiaris	95.98	0.00e+00	743.00
IUUC-Cpo-021401	Cavia porcellus	93.09	0.00e+00	743.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	4.00e-30	126.00
IUUC-Csa-023369	Chlorocebus sabaeus	99.78	0.00e+00	776.00
IUUC-Dre-028526	Danio rerio	70.29	2.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	91.76	0.00e+00	690.00
IUUC-Ete-033081	Echinops telfairi	84.04	4.00e-94	338.00
IUUC-Eca-034387	Equus caballus	95.82	0.00e+00	714.00
IUUC-Eeu-034846	Erinaceus europaeus	82.03	2.00e-154	538.00
IUUC-Fca-035396	Felis catus	94.92	0.00e+00	764.00
IUUC-Fal-037457	Ficedula albicollis	76.52	6.00e-161	560.00
IUUC-Gga-040706	Gallus gallus	77.46	2.00e-157	548.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.04	8.00e-130	457.00
IUUC-Ggo-045338	Gorilla gorilla	99.79	0.00e+00	847.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	97.32	0.00e+00	756.00
IUUC-Lch-049638	Latimeria chalumnae	69.11	4.00e-147	514.00
IUUC-Loc-052427	Lepisosteus oculatus	75.28	5.00e-158	550.00
IUUC-Laf-053758	Loxodonta africana	89.20	0.00e+00	738.00
IUUC-Mcc-054755	Macaca mulatta	98.13	0.00e+00	828.00
IUUC-Mmr-060890	Microcebus murinus	96.43	0.00e+00	751.00
IUUC-Mdo-062197	Monodelphis domestica	81.00	9.00e-178	616.00
IUUC-Mmu-063823	Mus musculus	95.98	0.00e+00	750.00
IUUC-Mac-064858	Musa acuminata	43.27	9.00e-22	97.40
IUUC-Mpu-066181	Mustela putorius furo	95.54	0.00e+00	740.00
IUUC-Nle-069596	Nomascus leucogenys	100.00	0.00e+00	726.00
IUUC-Opr-070344	Ochotona princeps	95.15	0.00e+00	762.00
IUUC-Ont-071867	Oreochromis niloticus	70.79	2.00e-133	469.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.61	1.00e-156	545.00
IUUC-Ocu-074652	Oryctolagus cuniculus	94.73	0.00e+00	723.00
IUUC-Obr-076302	Oryza brachyantha	37.68	3.00e-17	83.60
IUUC-Osa-085602	Oryza sativa	37.43	2.00e-17	84.00
IUUC-Ola-086707	Oryzias latipes	71.15	8.00e-107	380.00
IUUC-Oga-088560	Otolemur garnettii	96.90	0.00e+00	719.00
IUUC-Oar-089200	Ovis aries	96.21	0.00e+00	706.00
IUUC-Ptr-090569	Pan troglodytes	99.78	0.00e+00	775.00
IUUC-Pan-091742	Papio anubis	99.78	0.00e+00	775.00
IUUC-Psi-093297	Pelodiscus sinensis	77.10	2.00e-133	468.00
IUUC-Pma-094612	Petromyzon marinus	77.75	2.00e-128	452.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	9.00e-28	118.00
IUUC-Pab-098531	Pongo abelii	99.78	0.00e+00	776.00
IUUC-Pca-101120	Procavia capensis	90.44	0.00e+00	746.00
IUUC-Pva-102934	Pteropus vampyrus	83.78	0.00e+00	717.00
IUUC-Rno-106052	Rattus norvegicus	95.31	0.00e+00	763.00
IUUC-Sha-106876	Sarcophilus harrisii	79.96	3.00e-174	604.00
IUUC-Ssc-115380	Sus scrofa	97.99	0.00e+00	783.00
IUUC-Tgu-117280	Taeniopygia guttata	77.17	7.00e-162	563.00
IUUC-Tbe-127632	Tupaia belangeri	97.98	0.00e+00	651.00
IUUC-Ttr-129008	Tursiops truncatus	92.78	0.00e+00	743.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence