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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046772
UUCD1 version UUC-HoS-00141
Ensembl Protein ID ENSP00000378624.3
UniProt Accession Q5GLZ8; Q5GC98; Q5GC99; Q5GCA0; Q8IXP9; Q9HCH9; HERC4_HUMAN
Genbank Protein ID AAO65480.1; AAV66578.1; AAV66579.1; AAV66580.1; BAB13419.1; CAH74148.1; CAH74148.1; CAH74148.1; CAI16032.1; CAI16032.1; CAI16032.1; AAH39600.1
Protein Name Probable E3 ubiquitin-protein ligase HERC4; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4
Genbank Nucleotide ID AY221963; AY650032; AY650033; AY650034; AB046813; AL356741; AC024258; AL133551; AL133551; AC024258; AL356741; BC039600
Gene Name HERC4; KIAA1593
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000148634.15 ENST00000277817.10 ENSP00000277817.6
ENSG00000148634.15 ENST00000412272.6 ENSP00000416504.2
ENSG00000148634.15 ENST00000395198.7 ENSP00000378624.3
ENSG00000148634.15 ENST00000427635.6 ENSP00000406171.2
ENSG00000148634.15 ENST00000473533.6 ENSP00000423671.1
ENSG00000148634.15 ENST00000373700.8 ENSP00000362804.4
ENSG00000148634.15 ENST00000513996.5 ENSP00000427191.1
ENSG00000148634.15 ENST00000492996.6 ENSP00000422383.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20133869
Classification
Family E-value Score Start End
E3 activity/HECT 6.90e-101 339.7 733 1056
Active Site
Position(s) Description Evidence
1025 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl+++
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNCTIVDLHFP 817
           78999***********************************************88877.....689************************* PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
            ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++v+y+++
   Q: 818  LALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFN 906
           ************************************9**998.*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssr 273
           +++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+fL F+Tgs+r
   Q: 907  KSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDR 996
           ****************************************************************************************** PP
   S: 274  lPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 997  IPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
           **********...7777758889**************************************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
 Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
Protein Sequence
(Fasta)
MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046772|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTCCGGCC AGCCCCTCCC CCGCCTCCCT CGCGTGGCCA CCTCCCCCTC TGCCTTCTCC 60
TACCCAGTCT CTTCCCCAAC TCTCCCCACC CCTGGTGCTC TCCGCCCCGC TTGCCTCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046772|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0007283--P:spermatogenesis
KEGG hsa:26091
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001666 Ailuropoda melanoleuca 97.92 0.00e+00 2008.00
IUUC-Apl-003295 Anas platyrhynchos 88.28 0.00e+00 1875.00
IUUC-Aca-004336 Anolis carolinensis 86.13 0.00e+00 1820.00
IUUC-Ame-010768 Astyanax mexicanus 73.16 0.00e+00 1573.00
IUUC-Bta-013279 Bos taurus 97.54 0.00e+00 2002.00
IUUC-Cja-019023 Callithrix jacchus 98.39 0.00e+00 2018.00
IUUC-Cfa-021074 Canis familiaris 98.11 0.00e+00 2014.00
IUUC-Cpo-021461 Cavia porcellus 95.75 0.00e+00 1956.00
IUUC-Csa-024261 Chlorocebus sabaeus 98.86 0.00e+00 2028.00
IUUC-Cho-024513 Choloepus hoffmanni 77.77 0.00e+00 1486.00
IUUC-Cin-025232 Ciona intestinalis 42.72 0.00e+00 814.00
IUUC-Dre-028829 Danio rerio 74.72 0.00e+00 1561.00
IUUC-Dno-029445 Dasypus novemcinctus 94.82 0.00e+00 1620.00
IUUC-Dor-030158 Dipodomys ordii 97.14 0.00e+00 878.00
IUUC-Dme-032103 Drosophila melanogaster 45.07 0.00e+00 894.00
IUUC-Ete-033072 Echinops telfairi 86.38 0.00e+00 1722.00
IUUC-Eca-033317 Equus caballus 95.74 0.00e+00 1959.00
IUUC-Fca-035682 Felis catus 97.54 0.00e+00 1994.00
IUUC-Fal-036969 Ficedula albicollis 87.13 0.00e+00 1848.00
IUUC-Gmo-038671 Gadus morhua 74.04 0.00e+00 1571.00
IUUC-Gga-041174 Gallus gallus 88.17 0.00e+00 1875.00
IUUC-Gac-042600 Gasterosteus aculeatus 73.87 0.00e+00 1512.00
IUUC-Ggo-044589 Gorilla gorilla 99.62 0.00e+00 2070.00
IUUC-Lch-050147 Latimeria chalumnae 80.57 0.00e+00 1432.00
IUUC-Loc-052684 Lepisosteus oculatus 80.70 0.00e+00 1704.00
IUUC-Laf-053844 Loxodonta africana 97.26 0.00e+00 1990.00
IUUC-Mcc-055531 Macaca mulatta 96.58 0.00e+00 2013.00
IUUC-Mga-060151 Meleagris gallopavo 87.56 0.00e+00 1561.00
IUUC-Mmr-060954 Microcebus murinus 98.20 0.00e+00 2013.00
IUUC-Mdo-062246 Monodelphis domestica 92.16 0.00e+00 1773.00
IUUC-Mmu-063369 Mus musculus 96.22 0.00e+00 1985.00
IUUC-Mpu-065936 Mustela putorius furo 97.35 0.00e+00 1845.00
IUUC-Mlu-067326 Myotis lucifugus 97.35 0.00e+00 1968.00
IUUC-Nle-069453 Nomascus leucogenys 98.49 0.00e+00 2009.00
IUUC-Ont-071720 Oreochromis niloticus 74.62 0.00e+00 1567.00
IUUC-Oan-073464 Ornithorhynchus anatinus 92.67 0.00e+00 1793.00
IUUC-Ocu-074207 Oryctolagus cuniculus 95.85 0.00e+00 1852.00
IUUC-Ola-086762 Oryzias latipes 74.24 0.00e+00 1532.00
IUUC-Oga-088435 Otolemur garnettii 98.20 0.00e+00 2014.00
IUUC-Oar-089233 Ovis aries 97.54 0.00e+00 2001.00
IUUC-Ptr-091368 Pan troglodytes 99.62 0.00e+00 2067.00
IUUC-Pan-092300 Papio anubis 98.86 0.00e+00 2028.00
IUUC-Psi-093406 Pelodiscus sinensis 89.59 0.00e+00 1892.00
IUUC-Pma-094113 Petromyzon marinus 71.41 0.00e+00 1137.00
IUUC-Ppa-095354 Physcomitrella patens 32.29 1.00e-146 514.00
IUUC-Pfo-097021 Poecilia formosa 73.23 0.00e+00 1574.00
IUUC-Pab-098327 Pongo abelii 99.43 0.00e+00 2063.00
IUUC-Pca-101075 Procavia capensis 96.04 0.00e+00 821.00
IUUC-Pva-102909 Pteropus vampyrus 86.38 0.00e+00 1694.00
IUUC-Rno-105457 Rattus norvegicus 96.97 0.00e+00 2006.00
IUUC-Sha-106632 Sarcophilus harrisii 93.47 0.00e+00 1949.00
IUUC-Sar-113679 Sorex araneus 87.90 0.00e+00 1146.00
IUUC-Tgu-116849 Taeniopygia guttata 83.25 0.00e+00 1739.00
IUUC-Tru-118206 Takifugu rubripes 72.89 0.00e+00 1472.00
IUUC-Tsy-119521 Tarsius syrichta 83.63 0.00e+00 1620.00
IUUC-Tni-120233 Tetraodon nigroviridis 72.14 0.00e+00 1462.00
IUUC-Tbe-127941 Tupaia belangeri 81.03 0.00e+00 1370.00
IUUC-Ttr-128926 Tursiops truncatus 97.60 0.00e+00 1182.00
IUUC-Vpa-130448 Vicugna pacos 96.97 0.00e+00 1989.00
IUUC-Xtr-132719 Xenopus tropicalis 70.60 0.00e+00 1384.00
Created Date 25-Jun-2017

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