iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046280

UUCD1 version

UUC-HoS-00469

Ensembl Protein ID

ENSP00000244061.2

UniProt Accession

Q9Y508; B2RDQ9; B4DWY5; E1P627; Q6N0B0; RN114_HUMAN

Genbank Protein ID

AAF75763.1; CAE45709.1; AAP35441.1; BAG38006.1; BAG63197.1; CAB46028.1; EAW75641.1; EAW75643.1; AAH13695.1; AAH66919.1

Protein Name

E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313

Genbank Nucleotide ID

AF265215; BX640603; BT006795; AK315638; AK301731; AL031685; CH471077; CH471077; BC013695; BC066919

Gene Name

RNF114; ZNF228; ZNF313

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000124226.10	ENST00000623528.3	ENSP00000485136.1
ENSG00000124226.10	ENST00000244061.5	ENSP00000244061.2
ENSG00000124226.10	ENST00000622999.3	ENSP00000485203.1
ENSG00000124226.10	ENST00000623732.3	ENSP00000485575.1
ENSG00000124226.10	ENST00000625177.3	ENSP00000485239.1
ENSG00000124226.10	ENST00000622920.1	ENSP00000485317.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18364390; 23645206

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	6.00e-07	31.1	26	72
E3 activity/RING/RING	5.90e-06	28.4	29	68

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplt 51
            f Cp+ le+ + Pv +p+G+++  ++++++l+ ++  c v+r+ l+
   Q: 26   RFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALA 72
           69*****************************************9986 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle +++ p+ +pCgHvf+  Clq       ++ k+  C +Cr
   Q: 29   CPVCLEVYEK-PVQVPCGHVFCSACLQEC-----LKPKKPVCGVCR 68
           **********.999************555.....499999*****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Protein Sequence
(Fasta)

MAAQQRDCGG AAQLAGPAAE ADPLGRFTCP VCLEVYEKPV QVPCGHVFCS ACLQECLKPK 60
KPVCGVCRSA LAPGVRAVEL ERQIESTETS CHGCRKNFFL SKIRSHVATC SKYQNYIMEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCACCGCC CCGCGAGCCC CGCCCCCTCG GCCTCCTCCT CATCGGCCGC CGTTGCGCGG 60
CGCAGAGCGG CAGCAAGATG GCGGCGCAAC AGCGGGACTG CGGGGGTGCT GCGCAGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis

KEGG

hsa:55905

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002315	Ailuropoda melanoleuca	94.30	2.00e-128	451.00
IUUC-Apl-004036	Anas platyrhynchos	76.80	2.00e-82	298.00
IUUC-Aca-004569	Anolis carolinensis	71.56	1.00e-96	345.00
IUUC-Bta-013345	Bos taurus	92.67	1.00e-125	442.00
IUUC-Cja-019919	Callithrix jacchus	96.05	2.00e-130	457.00
IUUC-Cfa-021164	Canis familiaris	94.30	1.00e-127	448.00
IUUC-Cpo-022051	Cavia porcellus	86.36	1.00e-114	405.00
IUUC-Csa-023956	Chlorocebus sabaeus	99.52	3.00e-123	434.00
IUUC-Dre-027499	Danio rerio	53.23	8.00e-66	243.00
IUUC-Dno-029437	Dasypus novemcinctus	93.91	3.00e-123	434.00
IUUC-Dor-030428	Dipodomys ordii	78.51	8.00e-103	366.00
IUUC-Ete-032855	Echinops telfairi	77.83	3.00e-94	337.00
IUUC-Eca-034236	Equus caballus	96.13	1.00e-102	365.00
IUUC-Eeu-034875	Erinaceus europaeus	96.28	2.00e-107	381.00
IUUC-Fca-036017	Felis catus	97.17	4.00e-123	433.00
IUUC-Fal-037133	Ficedula albicollis	75.69	1.00e-83	302.00
IUUC-Gga-040752	Gallus gallus	72.27	6.00e-96	343.00
IUUC-Ggo-044654	Gorilla gorilla	100.00	1.00e-77	281.00
IUUC-Itr-048594	Ictidomys tridecemlineatus	94.62	6.00e-103	366.00
IUUC-Lch-050028	Latimeria chalumnae	62.86	1.00e-79	289.00
IUUC-Loc-051797	Lepisosteus oculatus	59.90	3.00e-70	258.00
IUUC-Laf-054248	Loxodonta africana	95.03	2.00e-103	367.00
IUUC-Mcc-054724	Macaca mulatta	99.52	3.00e-123	434.00
IUUC-Meu-056464	Macropus eugenii	59.12	8.00e-52	196.00
IUUC-Mga-059403	Meleagris gallopavo	73.57	2.00e-61	227.00
IUUC-Mmr-061582	Microcebus murinus	96.69	3.00e-104	370.00
IUUC-Mdo-062106	Monodelphis domestica	79.00	7.00e-100	356.00
IUUC-Mmu-064176	Mus musculus	89.87	7.00e-113	399.00
IUUC-Mpu-066083	Mustela putorius furo	95.18	2.00e-129	454.00
IUUC-Mlu-067060	Myotis lucifugus	94.20	5.00e-116	410.00
IUUC-Nle-069353	Nomascus leucogenys	99.52	6.00e-114	402.00
IUUC-Opr-070916	Ochotona princeps	88.60	1.00e-121	428.00
IUUC-Ont-072284	Oreochromis niloticus	56.73	1.00e-71	262.00
IUUC-Oan-072858	Ornithorhynchus anatinus	76.80	4.00e-82	296.00
IUUC-Ocu-074471	Oryctolagus cuniculus	93.86	6.00e-118	416.00
IUUC-Oin-079762	Oryza indica	52.17	5.00e-09	55.80
IUUC-Ola-087569	Oryzias latipes	53.88	7.00e-73	266.00
IUUC-Olu-087618	Ostreococcus lucimarinus	40.35	1.00e-07	50.40
IUUC-Oga-089164	Otolemur garnettii	96.68	8.00e-122	429.00
IUUC-Oar-089436	Ovis aries	94.22	7.00e-126	442.00
IUUC-Ptr-090945	Pan troglodytes	100.00	2.00e-127	447.00
IUUC-Pan-092765	Papio anubis	99.52	3.00e-123	434.00
IUUC-Psi-093593	Pelodiscus sinensis	75.35	4.00e-64	236.00
IUUC-Pfo-096157	Poecilia formosa	54.72	2.00e-69	255.00
IUUC-Pab-098509	Pongo abelii	99.04	4.00e-124	436.00
IUUC-Pca-100293	Procavia capensis	90.59	4.00e-107	380.00
IUUC-Pva-102556	Pteropus vampyrus	92.11	2.00e-124	437.00
IUUC-Rno-105634	Rattus norvegicus	88.99	6.00e-111	393.00
IUUC-Sha-107052	Sarcophilus harrisii	78.37	2.00e-92	331.00
IUUC-Sar-113680	Sorex araneus	92.27	5.00e-91	326.00
IUUC-Ssc-115451	Sus scrofa	95.58	1.00e-103	368.00
IUUC-Tgu-116515	Taeniopygia guttata	75.41	4.00e-83	300.00
IUUC-Tru-117712	Takifugu rubripes	54.05	1.00e-71	262.00
IUUC-Tsy-119419	Tarsius syrichta	96.13	3.00e-103	367.00
IUUC-Tni-119774	Tetraodon nigroviridis	55.50	3.00e-71	261.00
IUUC-Tbe-127924	Tupaia belangeri	89.87	2.00e-115	407.00
IUUC-Ttr-128721	Tursiops truncatus	93.86	3.00e-128	450.00
IUUC-Vpa-130175	Vicugna pacos	69.83	2.00e-85	308.00
IUUC-Xtr-131851	Xenopus tropicalis	57.77	7.00e-73	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence