iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.50e-16	58.8	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFS HEGGSRSENV DMNANRCLSV KEKSVSLGEA APRQQSSPLR 60
ENIALQLGLS PSKTFSRRNQ NCAAEIPQVV EISIEKDSDS SATPGTRLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGGCCGG GCAGGAGCGG AGGACGGGAC GCGCGGGCGG TCGCCCTCGC CCTGTCGCTG 60
ACTGCGCCGC CCCGGCCCAT CCTGCCTGGC CGCAGGTGCC CTGGATGAGG CCGCCGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

rno:500616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.30e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	90.30	0.00e+00	998.00
IUUC-Aca-004504	Anolis carolinensis	84.89	0.00e+00	877.00
IUUC-Ame-010677	Astyanax mexicanus	63.41	0.00e+00	640.00
IUUC-Bta-012338	Bos taurus	95.15	0.00e+00	1028.00
IUUC-Cja-019828	Callithrix jacchus	94.96	0.00e+00	1009.00
IUUC-Cfa-020369	Canis familiaris	94.22	0.00e+00	1021.00
IUUC-Cpo-021397	Cavia porcellus	93.10	0.00e+00	1035.00
IUUC-Csa-023856	Chlorocebus sabaeus	94.78	0.00e+00	1025.00
IUUC-Dre-028262	Danio rerio	64.18	4.00e-174	604.00
IUUC-Dno-029019	Dasypus novemcinctus	94.59	0.00e+00	1049.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	9.00e-70	258.00
IUUC-Eca-033867	Equus caballus	94.22	0.00e+00	1042.00
IUUC-Fca-035806	Felis catus	94.22	0.00e+00	1023.00
IUUC-Fal-037117	Ficedula albicollis	89.55	0.00e+00	986.00
IUUC-Fso-038185	Fusarium solani	32.81	2.20e-01	29.30
IUUC-Gmo-039066	Gadus morhua	84.91	5.00e-109	388.00
IUUC-Gga-040876	Gallus gallus	89.74	0.00e+00	974.00
IUUC-Gac-042149	Gasterosteus aculeatus	67.59	0.00e+00	647.00
IUUC-Ggo-045169	Gorilla gorilla	94.03	0.00e+00	1019.00
IUUC-Hsa-045805	Homo sapiens	95.15	0.00e+00	1027.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.90e-02	32.70
IUUC-Itr-049048	Ictidomys tridecemlineatus	94.78	0.00e+00	1045.00
IUUC-Lch-049686	Latimeria chalumnae	78.85	0.00e+00	840.00
IUUC-Lpe-051639	Leersia perrieri	30.77	3.00e-01	30.40
IUUC-Loc-051745	Lepisosteus oculatus	73.32	0.00e+00	719.00
IUUC-Lma-053042	Leptosphaeria maculans	27.63	3.00e+00	29.60
IUUC-Laf-054124	Loxodonta africana	92.36	0.00e+00	1013.00
IUUC-Mcc-055175	Macaca mulatta	94.78	0.00e+00	1025.00
IUUC-Meu-056557	Macropus eugenii	90.72	0.00e+00	1006.00
IUUC-Mga-059214	Meleagris gallopavo	89.18	0.00e+00	985.00
IUUC-Mmr-060613	Microcebus murinus	79.48	0.00e+00	797.00
IUUC-Mdo-062788	Monodelphis domestica	90.35	0.00e+00	971.00
IUUC-Mmu-064333	Mus musculus	97.57	0.00e+00	1046.00
IUUC-Mpu-066048	Mustela putorius furo	94.96	0.00e+00	1026.00
IUUC-Mlu-067430	Myotis lucifugus	94.59	0.00e+00	1001.00
IUUC-Nle-069086	Nomascus leucogenys	94.78	0.00e+00	1050.00
IUUC-Opr-070312	Ochotona princeps	91.79	0.00e+00	992.00
IUUC-Ont-072299	Oreochromis niloticus	65.19	0.00e+00	646.00
IUUC-Ocu-074123	Oryctolagus cuniculus	90.11	0.00e+00	966.00
IUUC-Ola-086934	Oryzias latipes	68.39	0.00e+00	673.00
IUUC-Oga-088535	Otolemur garnettii	94.59	0.00e+00	1047.00
IUUC-Oar-089875	Ovis aries	95.15	0.00e+00	1030.00
IUUC-Ptr-090541	Pan troglodytes	95.15	0.00e+00	1027.00
IUUC-Pan-092416	Papio anubis	94.78	0.00e+00	1025.00
IUUC-Psi-092960	Pelodiscus sinensis	87.69	0.00e+00	975.00
IUUC-Pma-094222	Petromyzon marinus	52.16	2.00e-138	486.00
IUUC-Pfo-096930	Poecilia formosa	64.72	0.00e+00	658.00
IUUC-Pab-098659	Pongo abelii	94.78	0.00e+00	1026.00
IUUC-Pca-100222	Procavia capensis	91.25	0.00e+00	1005.00
IUUC-Pva-102387	Pteropus vampyrus	94.59	0.00e+00	1018.00
IUUC-Sha-107234	Sarcophilus harrisii	89.24	0.00e+00	971.00
IUUC-Sar-113698	Sorex araneus	87.87	0.00e+00	902.00
IUUC-Ssc-115985	Sus scrofa	94.78	0.00e+00	1048.00
IUUC-Tgu-116676	Taeniopygia guttata	89.74	0.00e+00	989.00
IUUC-Tru-118441	Takifugu rubripes	59.71	8.00e-153	533.00
IUUC-Tsy-119163	Tarsius syrichta	89.55	0.00e+00	986.00
IUUC-Tni-120436	Tetraodon nigroviridis	67.47	0.00e+00	654.00
IUUC-Tae-124846	Triticum aestivum	36.73	2.70e-02	32.00
IUUC-Tbe-127353	Tupaia belangeri	94.40	0.00e+00	1023.00
IUUC-Ttr-128907	Tursiops truncatus	95.15	0.00e+00	1011.00
IUUC-Vpa-130140	Vicugna pacos	95.15	0.00e+00	1028.00
IUUC-Xtr-132817	Xenopus tropicalis	80.07	0.00e+00	875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence