iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132817

UUCD1 version

UUC-XeT-00889

Ensembl Protein ID

ENSXETP00000049206.2

UniProt Accession

Q28DL3; Q28DL3_XENTR

Genbank Protein ID

AAI61341.1; CAJ83263.1

Protein Name

Suppressor of cytokine signaling 5; Suppressor of cytokine-signaling 5

Genbank Nucleotide ID

AAMC01011701; CR855450

Gene Name

socs5; TNeu050n02.1-001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000022744.2	ENSXETT00000049206.2	ENSXETP00000049206.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-14	53.7	473	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            +l r+ p+SLq++CR +I+r+++++++   d LPLP++L+d+L++++y+
   Q: 473  VPLNRTFPFSLQYICRAVICRSTTYDGI---DLLPLPSMLQDFLKEYHYK 519
           5678999*********************...****************985 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MDKVEKMWNT FKYRCQNLFS HDDEANQNDT VDVNANRCLG GIDKNENASG QSAMLSIGPL 60
QQNITSELSP SSSSSRRNQN CVSEMPQLVE ISVERDNDSG LSAGTRLARR DSYTRHAPWG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGCAGCGG GCCAATTTCT ATCAGAATCG GAGAGATTTC ATCTTTTCGG CACTCAATCT 60
TGTGATCCTG TTGCCTTGGA ACCGGAATGT TCGCATCGCT TACAGGCATC CCTGCACTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

xtr:549598

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	32.65	9.80e-02	29.60
IUUC-Apl-003815	Anas platyrhynchos	79.70	0.00e+00	868.00
IUUC-Aca-004504	Anolis carolinensis	75.84	0.00e+00	776.00
IUUC-Ame-010677	Astyanax mexicanus	60.81	2.00e-180	625.00
IUUC-Bta-012338	Bos taurus	80.07	0.00e+00	856.00
IUUC-Cja-019828	Callithrix jacchus	80.26	0.00e+00	847.00
IUUC-Cfa-020369	Canis familiaris	79.33	0.00e+00	855.00
IUUC-Cpo-021397	Cavia porcellus	79.52	0.00e+00	869.00
IUUC-Csa-023856	Chlorocebus sabaeus	80.45	0.00e+00	861.00
IUUC-Dre-028262	Danio rerio	59.19	7.00e-166	577.00
IUUC-Dno-029019	Dasypus novemcinctus	80.45	0.00e+00	877.00
IUUC-Dme-031965	Drosophila melanogaster	66.86	9.00e-70	258.00
IUUC-Eca-033867	Equus caballus	79.70	0.00e+00	872.00
IUUC-Fca-035806	Felis catus	79.52	0.00e+00	855.00
IUUC-Fal-037117	Ficedula albicollis	78.96	0.00e+00	855.00
IUUC-Gmo-039066	Gadus morhua	83.89	8.00e-108	384.00
IUUC-Gga-040876	Gallus gallus	79.70	0.00e+00	849.00
IUUC-Gac-042149	Gasterosteus aculeatus	64.56	1.00e-180	625.00
IUUC-Ggo-045169	Gorilla gorilla	79.52	0.00e+00	853.00
IUUC-Hsa-045805	Homo sapiens	80.63	0.00e+00	862.00
IUUC-Hvu-047122	Hordeum vulgare	38.89	2.10e-01	29.30
IUUC-Itr-049048	Ictidomys tridecemlineatus	79.70	0.00e+00	870.00
IUUC-Lch-049686	Latimeria chalumnae	75.56	0.00e+00	789.00
IUUC-Lpe-051639	Leersia perrieri	32.31	7.40e-01	28.90
IUUC-Loc-051745	Lepisosteus oculatus	67.31	0.00e+00	679.00
IUUC-Laf-054124	Loxodonta africana	79.00	0.00e+00	861.00
IUUC-Mcc-055175	Macaca mulatta	80.45	0.00e+00	861.00
IUUC-Meu-056557	Macropus eugenii	78.89	0.00e+00	861.00
IUUC-Mga-059214	Meleagris gallopavo	79.70	0.00e+00	867.00
IUUC-Mvi-060418	Microbotryum violaceum	29.36	2.10e-02	32.30
IUUC-Mmr-060613	Microcebus murinus	65.55	0.00e+00	642.00
IUUC-Mdo-062788	Monodelphis domestica	78.15	0.00e+00	828.00
IUUC-Mmu-064333	Mus musculus	79.14	0.00e+00	851.00
IUUC-Mpu-066048	Mustela putorius furo	79.89	0.00e+00	858.00
IUUC-Mlu-067430	Myotis lucifugus	79.70	0.00e+00	844.00
IUUC-Nle-069086	Nomascus leucogenys	80.45	0.00e+00	879.00
IUUC-Opr-070312	Ochotona princeps	78.21	0.00e+00	833.00
IUUC-Ont-072299	Oreochromis niloticus	62.46	0.00e+00	630.00
IUUC-Ocu-074123	Oryctolagus cuniculus	77.65	0.00e+00	823.00
IUUC-Ola-086934	Oryzias latipes	64.76	0.00e+00	636.00
IUUC-Oga-088535	Otolemur garnettii	80.26	0.00e+00	878.00
IUUC-Oar-089875	Ovis aries	79.70	0.00e+00	856.00
IUUC-Ptr-090541	Pan troglodytes	80.63	0.00e+00	862.00
IUUC-Pan-092416	Papio anubis	80.45	0.00e+00	861.00
IUUC-Psi-092960	Pelodiscus sinensis	77.84	0.00e+00	847.00
IUUC-Pma-094222	Petromyzon marinus	51.47	2.00e-133	468.00
IUUC-Pfo-096930	Poecilia formosa	62.59	0.00e+00	635.00
IUUC-Pab-098659	Pongo abelii	80.26	0.00e+00	860.00
IUUC-Pca-100222	Procavia capensis	78.81	0.00e+00	856.00
IUUC-Pva-102387	Pteropus vampyrus	80.26	0.00e+00	858.00
IUUC-Rno-105698	Rattus norvegicus	80.07	0.00e+00	857.00
IUUC-Sha-107234	Sarcophilus harrisii	77.22	0.00e+00	830.00
IUUC-Sar-113698	Sorex araneus	74.49	0.00e+00	754.00
IUUC-Ssc-115985	Sus scrofa	79.52	0.00e+00	871.00
IUUC-Tgu-116676	Taeniopygia guttata	79.33	0.00e+00	860.00
IUUC-Tru-118441	Takifugu rubripes	57.33	2.00e-146	512.00
IUUC-Tsy-119163	Tarsius syrichta	75.23	0.00e+00	814.00
IUUC-Tni-120436	Tetraodon nigroviridis	63.87	0.00e+00	631.00
IUUC-Tae-124846	Triticum aestivum	32.65	1.40e-01	29.30
IUUC-Tbe-127353	Tupaia belangeri	80.63	0.00e+00	862.00
IUUC-Ttr-128907	Tursiops truncatus	80.26	0.00e+00	850.00
IUUC-Vpa-130140	Vicugna pacos	80.26	0.00e+00	861.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence