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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018476
UUCD1 version UUC-CaE-00292
Ensembl Protein ID C32E8.11
UniProt Accession P91133; UBR1_CAEEL
Genbank Protein ID CCD66417.1
Protein Name E3 ubiquitin-protein ligase ubr-1; N-recognin-1; RING-type E3 ubiquitin transferase ubr-1; Ubiquitin-protein ligase E3-alpha
Genbank Nucleotide ID FO080749
Gene Name ubr-1; C32E8.11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00016326 C32E8.11 C32E8.11
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBasemicroRNARAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/N-recognin/UBR-box 5.20e-22 78.4 94 163
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/N-recognin/UBR-box
   S: 2    lCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
            Cg+vfk ge +y+C +C++d t+v+C +Cf+ ++Hk H+yk++ s+g+g+CdCGd+ Aw +g  C +++
   Q: 94   ICGHVFKNGELTYTCLDCATDGTCVMCLQCFEVSIHKSHKYKMHSSSGSGYCDCGDADAWTEGYACANHE 163
           7*******************************************************************97 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Protein Sequence
(Fasta)
MIVDLIQSAR QGEWAQVRQL LLKHWLVQVP EVFEVNSDLP WDNTAANERI LGSQGEILLA 60
PLVSAFVLDV RNTKSTLEAM NGIAGVDPAR RGQICGHVFK NGELTYTCLD CATDGTCVMC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018476|E3,UBR-box|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGATTGTCG ATTTAATACA ATCAGCTCGA CAGGGTGAAT GGGCCCAAGT ACGCCAGCTG 60
CTGCTCAAGC ACTGGCTTGT ACAGGTCCCA GAGGTGTTCG AAGTGAATTC GGATTTGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018476|E3,UBR-box|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02617--ClpS
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway
KEGG cel:CELE_C32E8.11
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000838 Aegilops tauschii 22.25 2.00e-11 64.30
IUUC-Aml-001354 Ailuropoda melanoleuca 28.84 1.00e-90 327.00
IUUC-Atr-002501 Amborella trichopoda 22.85 2.00e-16 81.60
IUUC-Apl-003828 Anas platyrhynchos 27.79 1.00e-97 350.00
IUUC-Aca-005189 Anolis carolinensis 29.26 4.00e-102 365.00
IUUC-Aly-005901 Arabidopsis lyrata 28.90 3.00e-13 70.90
IUUC-Ath-007148 Arabidopsis thaliana 24.57 1.00e-15 78.60
IUUC-Ago-007752 Ashbya gossypii 24.49 4.00e-11 63.50
IUUC-Acl-008055 Aspergillus clavatus 22.20 4.00e-27 116.00
IUUC-Afl-008479 Aspergillus flavus 21.68 3.00e-26 114.00
IUUC-Afu-008929 Aspergillus fumigatus 22.35 6.00e-27 116.00
IUUC-Ani-009334 Aspergillus nidulans 29.55 3.00e-25 110.00
IUUC-Ang-009550 Aspergillus niger 22.22 6.00e-29 122.00
IUUC-Aor-010124 Aspergillus oryzae 21.85 8.00e-27 115.00
IUUC-Ate-010550 Aspergillus terreus 22.03 8.00e-27 115.00
IUUC-Ame-011917 Astyanax mexicanus 30.69 2.00e-100 360.00
IUUC-Bgr-011999 Blumeria graminis 20.09 1.00e-21 98.60
IUUC-Bta-012768 Bos taurus 29.84 3.00e-105 376.00
IUUC-Bci-013834 Botrytis cinerea 30.62 4.00e-23 103.00
IUUC-Bdi-014635 Brachypodium distachyon 29.37 2.00e-19 91.30
IUUC-Cja-019797 Callithrix jacchus 29.58 2.00e-93 336.00
IUUC-Cfa-020950 Canis familiaris 28.61 4.00e-98 352.00
IUUC-Cpo-022385 Cavia porcellus 30.00 2.00e-101 363.00
IUUC-Csa-024082 Chlorocebus sabaeus 29.26 5.00e-100 358.00
IUUC-Cho-025029 Choloepus hoffmanni 32.06 3.00e-71 263.00
IUUC-Cin-025148 Ciona intestinalis 27.69 2.00e-57 216.00
IUUC-Cgl-026605 Colletotrichum gloeosporioides 32.09 4.00e-26 113.00
IUUC-Cne-026823 Cryptococcus neoformans 28.96 3.00e-17 84.00
IUUC-Dre-028343 Danio rerio 30.02 4.00e-106 379.00
IUUC-Dno-029427 Dasypus novemcinctus 28.78 7.00e-95 341.00
IUUC-Dor-030207 Dipodomys ordii 28.57 2.00e-60 227.00
IUUC-Dse-031531 Dothistroma septosporum 30.80 2.00e-22 101.00
IUUC-Dme-031910 Drosophila melanogaster 29.24 5.00e-95 342.00
IUUC-Ete-033162 Echinops telfairi 27.90 8.00e-67 248.00
IUUC-Eca-033454 Equus caballus 29.15 6.00e-98 352.00
IUUC-Eeu-034664 Erinaceus europaeus 39.45 6.00e-49 189.00
IUUC-Fca-036588 Felis catus 28.68 2.00e-98 353.00
IUUC-Fal-036919 Ficedula albicollis 27.19 6.00e-97 348.00
IUUC-Fox-037984 Fusarium oxysporum 32.06 2.00e-24 107.00
IUUC-Fso-038463 Fusarium solani 32.06 3.00e-25 110.00
IUUC-Gmo-039698 Gadus morhua 33.21 1.00e-76 280.00
IUUC-Ggr-040070 Gaeumannomyces graminis 34.74 7.00e-27 116.00
IUUC-Gga-041123 Gallus gallus 28.27 1.00e-100 360.00
IUUC-Gac-042622 Gasterosteus aculeatus 30.58 6.00e-104 371.00
IUUC-Gma-043622 Glycine max 28.43 4.00e-18 87.00
IUUC-Ggo-045583 Gorilla gorilla 29.15 2.00e-100 360.00
IUUC-Hsa-046343 Homo sapiens 29.39 2.00e-101 363.00
IUUC-Itr-048410 Ictidomys tridecemlineatus 28.75 2.00e-90 326.00
IUUC-Kpa-049088 Komagataella pastoris 29.15 5.00e-19 89.70
IUUC-Lch-049904 Latimeria chalumnae 30.64 5.00e-94 338.00
IUUC-Lpe-051516 Leersia perrieri 36.42 2.00e-19 91.30
IUUC-Loc-052818 Lepisosteus oculatus 28.16 7.00e-97 348.00
IUUC-Lma-053059 Leptosphaeria maculans 20.62 3.00e-29 124.00
IUUC-Laf-054142 Loxodonta africana 29.09 2.00e-99 357.00
IUUC-Mcc-055677 Macaca mulatta 29.26 4.00e-100 358.00
IUUC-Meu-056858 Macropus eugenii 30.63 1.00e-37 151.00
IUUC-Mor-057051 Magnaporthe oryzae 35.76 4.00e-25 110.00
IUUC-Mpo-057372 Magnaporthe poae 30.98 1.00e-20 94.70
IUUC-Mtr-058538 Medicago truncatula 22.55 3.00e-14 73.90
IUUC-Mla-058963 Melampsora laricipopulina 36.92 7.00e-24 106.00
IUUC-Mga-059698 Meleagris gallopavo 28.31 3.00e-99 355.00
IUUC-Mvi-060535 Microbotryum violaceum 23.64 5.00e-23 103.00
IUUC-Mmr-060901 Microcebus murinus 29.59 6.00e-101 361.00
IUUC-Mdo-062014 Monodelphis domestica 29.03 1.00e-100 360.00
IUUC-Mmu-063699 Mus musculus 29.50 2.00e-98 353.00
IUUC-Mpu-066153 Mustela putorius furo 29.08 2.00e-98 353.00
IUUC-Mlu-068151 Myotis lucifugus 29.77 2.00e-100 360.00
IUUC-Nfi-068403 Neosartorya fischeri 22.30 8.00e-27 115.00
IUUC-Ncr-068864 Neurospora crassa 28.63 2.00e-21 97.80
IUUC-Nle-069529 Nomascus leucogenys 29.36 2.00e-100 360.00
IUUC-Opr-071107 Ochotona princeps 30.00 1.00e-56 214.00
IUUC-Ont-072189 Oreochromis niloticus 30.48 5.00e-99 355.00
IUUC-Oan-072893 Ornithorhynchus anatinus 29.66 7.00e-102 365.00
IUUC-Ocu-074082 Oryctolagus cuniculus 27.86 1.00e-101 363.00
IUUC-Oba-075295 Oryza barthii 45.07 2.00e-11 65.10
IUUC-Obr-076117 Oryza brachyantha 29.15 4.00e-20 93.60
IUUC-Ogl-077571 Oryza glaberrima 37.11 9.00e-20 92.40
IUUC-Ogu-078497 Oryza glumaepatula 45.07 2.00e-11 65.10
IUUC-Oin-079343 Oryza indica 45.07 2.00e-11 65.10
IUUC-Olo-081056 Oryza longistaminata 45.07 2.00e-11 65.10
IUUC-Ome-081738 Oryza meridionalis 34.69 3.00e-08 53.90
IUUC-Oni-083099 Oryza nivara 45.07 2.00e-11 65.10
IUUC-Opu-083202 Oryza punctata 37.11 7.00e-20 92.80
IUUC-Oru-084471 Oryza rufipogon 45.07 2.00e-11 64.70
IUUC-Osa-085336 Oryza sativa 37.18 9.00e-20 91.30
IUUC-Ola-087460 Oryzias latipes 30.58 3.00e-104 372.00
IUUC-Oga-088432 Otolemur garnettii 29.49 8.00e-103 368.00
IUUC-Oar-090206 Ovis aries 29.19 2.00e-96 347.00
IUUC-Ptr-091180 Pan troglodytes 28.78 3.00e-98 353.00
IUUC-Pan-092375 Papio anubis 29.36 2.00e-100 360.00
IUUC-Psi-093049 Pelodiscus sinensis 29.36 1.00e-97 350.00
IUUC-Pma-094116 Petromyzon marinus 36.18 2.00e-66 245.00
IUUC-Pno-094877 Phaeosphaeria nodorum 35.71 6.00e-26 112.00
IUUC-Ppa-095715 Physcomitrella patens 28.65 1.00e-19 92.00
IUUC-Pfo-097124 Poecilia formosa 30.75 6.00e-106 378.00
IUUC-Pab-097989 Pongo abelii 29.18 2.00e-99 357.00
IUUC-Pca-100673 Procavia capensis 28.00 1.00e-62 234.00
IUUC-Ppe-101802 Prunus persica 23.37 6.00e-16 79.70
IUUC-Pva-102724 Pteropus vampyrus 29.40 9.00e-89 321.00
IUUC-Pgr-103372 Puccinia graminis 34.69 1.00e-24 108.00
IUUC-Ptt-103878 Puccinia triticina 20.88 4.00e-22 100.00
IUUC-Pte-104174 Pyrenophora teres 21.75 4.00e-30 126.00
IUUC-Pyt-104431 Pyrenophora triticirepentis 34.71 2.00e-26 115.00
IUUC-Rno-105567 Rattus norvegicus 29.82 6.00e-98 352.00
IUUC-Sce-106272 Saccharomyces cerevisiae 39.74 1.00e-13 72.00
IUUC-Sha-106980 Sarcophilus harrisii 29.12 8.00e-101 361.00
IUUC-Sja-107980 Schizosaccharomyces japonicus 23.24 7.00e-27 115.00
IUUC-Spo-108183 Schizosaccharomyces pombe 24.95 6.00e-20 92.80
IUUC-Smo-108719 Selaginella moellendorffii 24.17 6.00e-17 83.20
IUUC-Sit-110716 Setaria italica 30.18 3.00e-21 97.40
IUUC-Sly-111701 Solanum lycopersicum 31.82 8.00e-17 82.40
IUUC-Sar-113447 Sorex araneus 28.42 4.00e-91 329.00
IUUC-Sbi-114577 Sorghum bicolor 36.73 1.00e-15 79.00
IUUC-Sre-115045 Sporisorium reilianum 25.94 2.00e-36 147.00
IUUC-Ssc-115525 Sus scrofa 29.57 5.00e-103 368.00
IUUC-Tgu-116943 Taeniopygia guttata 28.06 9.00e-99 354.00
IUUC-Tru-117673 Takifugu rubripes 30.38 4.00e-99 355.00
IUUC-Tsy-119032 Tarsius syrichta 32.68 8.00e-78 285.00
IUUC-Tni-119987 Tetraodon nigroviridis 29.90 2.00e-97 350.00
IUUC-Tre-122137 Trichoderma reesei 37.18 3.00e-25 110.00
IUUC-Tvi-122272 Trichoderma virens 23.38 1.00e-28 121.00
IUUC-Tae-125358 Triticum aestivum 30.52 2.00e-19 91.30
IUUC-Tur-126562 Triticum urartu 21.97 9.00e-12 65.50
IUUC-Tme-127156 Tuber melanosporum 23.02 2.00e-21 98.20
IUUC-Tbe-128088 Tupaia belangeri 35.71 2.00e-44 174.00
IUUC-Ttr-128253 Tursiops truncatus 29.68 6.00e-91 328.00
IUUC-Uma-129344 Ustilago maydis 25.45 1.00e-36 148.00
IUUC-Vda-129778 Verticillium dahliae 29.63 1.00e-24 108.00
IUUC-Vpa-130540 Vicugna pacos 28.54 2.00e-100 360.00
IUUC-Xtr-132690 Xenopus tropicalis 30.21 1.00e-95 344.00
IUUC-Xma-134112 Xiphophorus maculatus 30.30 3.00e-104 372.00
IUUC-Yli-134662 Yarrowia lipolytica 22.93 1.00e-23 105.00
IUUC-Zma-135553 Zea mays 34.69 2.00e-08 54.70
Created Date 25-Jun-2017

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