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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064373
UUCD1 version UUC-MuM-00179
Ensembl Protein ID ENSMUSP00000044801.6
UniProt Accession E9PZP8; E9PZP8_MOUSE
Genbank Protein ID ENSMUSP00000044801
Protein Name HECT and RLD domain-containing E3 ubiquitin protein ligase family member 1
Genbank Nucleotide ID AC161382
Gene Name Herc1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038664.16 ENSMUST00000042824.12 ENSMUSP00000044801.6
ENSMUSG00000038664.16 ENSMUST00000135159.1 ENSMUSP00000119991.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.60e-91 307.2 4506 4840
E3 adaptor/Cullin RING/DCX/DWD 1.20e-14 54.9 3426 3456
Active Site
Position(s) Description Evidence
4809 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4506 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4592
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4593 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4679
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei v+ lkk  +y++ + e+++ +qw+w++leefs+
   Q: 4680 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYRE-VDEQHQLVQWLWRTLEEFSN 4764
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4765 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4840
           *****************6.899999.679999956666***********************************99987 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3426 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3456
           55416677.*9778****************97 PP
   
Organism Mus musculus
Protein Sequence
(Fasta)
MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVTVLYSK LISNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064373|E3,HECT;E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGCCGCCG TCGCTGCCGC CGCTGCCGCC GCCGCCTCTT ACGTCTTTCC CTTTGACAAG 60
TCGCCGCCGC TGCAGCAAAA ATATAAAGGA CGCGGCTAGC GCGGCCGCTG GCCAGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064373|E3,HECT;E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development
KEGG mmu:235439
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001830 Ailuropoda melanoleuca 97.22 0.00e+00 8787.00
IUUC-Apl-003461 Anas platyrhynchos 92.81 0.00e+00 8403.00
IUUC-Aca-004452 Anolis carolinensis 85.21 0.00e+00 7436.00
IUUC-Aly-006545 Arabidopsis lyrata 36.36 1.00e-48 188.00
IUUC-Ame-011268 Astyanax mexicanus 60.89 0.00e+00 2243.00
IUUC-Bta-013213 Bos taurus 97.49 0.00e+00 8765.00
IUUC-Bdi-014791 Brachypodium distachyon 34.99 2.00e-52 200.00
IUUC-Bra-017584 Brassica rapa 34.72 2.00e-50 194.00
IUUC-Cja-019298 Callithrix jacchus 97.24 0.00e+00 8805.00
IUUC-Cfa-021213 Canis familiaris 97.24 0.00e+00 8855.00
IUUC-Cpo-021674 Cavia porcellus 96.29 0.00e+00 5949.00
IUUC-Cre-023014 Chlamydomonas reinhardtii 38.76 3.00e-50 192.00
IUUC-Csa-023341 Chlorocebus sabaeus 96.98 0.00e+00 8771.00
IUUC-Cho-024567 Choloepus hoffmanni 95.90 0.00e+00 1808.00
IUUC-Dre-028289 Danio rerio 78.96 0.00e+00 7112.00
IUUC-Dno-029988 Dasypus novemcinctus 96.73 0.00e+00 8727.00
IUUC-Dor-030636 Dipodomys ordii 94.98 0.00e+00 2154.00
IUUC-Ete-032598 Echinops telfairi 85.19 0.00e+00 1372.00
IUUC-Eca-033754 Equus caballus 97.41 0.00e+00 8805.00
IUUC-Eeu-034702 Erinaceus europaeus 92.03 0.00e+00 1510.00
IUUC-Fca-035900 Felis catus 97.76 0.00e+00 8854.00
IUUC-Fal-037034 Ficedula albicollis 90.92 0.00e+00 7235.00
IUUC-Gmo-039260 Gadus morhua 75.33 0.00e+00 1272.00
IUUC-Gga-040321 Gallus gallus 92.95 0.00e+00 8483.00
IUUC-Gac-042444 Gasterosteus aculeatus 57.35 0.00e+00 2227.00
IUUC-Gma-043808 Glycine max 33.68 2.00e-46 181.00
IUUC-Ggo-045134 Gorilla gorilla 92.28 0.00e+00 4741.00
IUUC-Hsa-046516 Homo sapiens 97.12 0.00e+00 8762.00
IUUC-Itr-048914 Ictidomys tridecemlineatus 97.83 0.00e+00 2574.00
IUUC-Lch-049903 Latimeria chalumnae 87.11 0.00e+00 7926.00
IUUC-Lpe-051165 Leersia perrieri 34.08 7.00e-51 194.00
IUUC-Loc-052149 Lepisosteus oculatus 85.07 0.00e+00 5455.00
IUUC-Laf-053426 Loxodonta africana 97.02 0.00e+00 8820.00
IUUC-Mcc-055826 Macaca mulatta 97.28 0.00e+00 8823.00
IUUC-Meu-056521 Macropus eugenii 85.50 0.00e+00 2261.00
IUUC-Mga-059567 Meleagris gallopavo 95.68 0.00e+00 2117.00
IUUC-Mmr-061512 Microcebus murinus 97.12 0.00e+00 8736.00
IUUC-Mdo-062177 Monodelphis domestica 92.29 0.00e+00 8328.00
IUUC-Mpu-066148 Mustela putorius furo 96.91 0.00e+00 8775.00
IUUC-Mlu-067680 Myotis lucifugus 96.93 0.00e+00 8730.00
IUUC-Nle-069633 Nomascus leucogenys 97.00 0.00e+00 8742.00
IUUC-Opr-070609 Ochotona princeps 95.70 0.00e+00 1459.00
IUUC-Ont-071249 Oreochromis niloticus 81.62 0.00e+00 7497.00
IUUC-Oan-073157 Ornithorhynchus anatinus 93.55 0.00e+00 8425.00
IUUC-Ocu-074841 Oryctolagus cuniculus 97.37 0.00e+00 8866.00
IUUC-Oba-075262 Oryza barthii 33.92 7.00e-49 188.00
IUUC-Obr-076115 Oryza brachyantha 34.10 1.00e-48 187.00
IUUC-Ogl-077586 Oryza glaberrima 33.92 7.00e-49 187.00
IUUC-Ogu-078796 Oryza glumaepatula 33.67 3.00e-48 186.00
IUUC-Oin-079298 Oryza indica 33.67 3.00e-48 186.00
IUUC-Oni-082049 Oryza nivara 33.67 3.00e-48 186.00
IUUC-Opu-083608 Oryza punctata 33.75 4.00e-49 188.00
IUUC-Oru-084712 Oryza rufipogon 33.67 3.00e-48 186.00
IUUC-Osa-086078 Oryza sativa 33.67 3.00e-48 186.00
IUUC-Ola-086889 Oryzias latipes 80.25 0.00e+00 7328.00
IUUC-Oga-088459 Otolemur garnettii 96.69 0.00e+00 8748.00
IUUC-Oar-089888 Ovis aries 97.51 0.00e+00 8737.00
IUUC-Ptr-091114 Pan troglodytes 97.14 0.00e+00 8795.00
IUUC-Pan-092442 Papio anubis 97.16 0.00e+00 8801.00
IUUC-Psi-093833 Pelodiscus sinensis 92.51 0.00e+00 5531.00
IUUC-Pma-094275 Petromyzon marinus 77.39 0.00e+00 1738.00
IUUC-Ppa-095790 Physcomitrella patens 35.80 7.00e-55 207.00
IUUC-Pfo-097262 Poecilia formosa 80.35 0.00e+00 7187.00
IUUC-Pab-097760 Pongo abelii 97.10 0.00e+00 4998.00
IUUC-Pop-099121 Populus trichocarpa 36.63 8.00e-52 199.00
IUUC-Pca-100465 Procavia capensis 95.97 0.00e+00 4605.00
IUUC-Ppe-101345 Prunus persica 34.02 4.00e-52 200.00
IUUC-Pva-102950 Pteropus vampyrus 96.39 0.00e+00 4116.00
IUUC-Rno-104892 Rattus norvegicus 99.14 0.00e+00 8854.00
IUUC-Sha-106633 Sarcophilus harrisii 93.68 0.00e+00 8329.00
IUUC-Smo-108827 Selaginella moellendorffii 35.14 2.00e-51 198.00
IUUC-Sly-111155 Solanum lycopersicum 36.24 2.00e-53 204.00
IUUC-Stu-112166 Solanum tuberosum 31.97 3.00e-49 190.00
IUUC-Sar-113251 Sorex araneus 87.57 0.00e+00 2510.00
IUUC-Ssc-116391 Sus scrofa 97.45 0.00e+00 8801.00
IUUC-Tgu-116554 Taeniopygia guttata 92.32 0.00e+00 8398.00
IUUC-Tru-118695 Takifugu rubripes 81.05 0.00e+00 7462.00
IUUC-Tsy-119647 Tarsius syrichta 90.98 0.00e+00 5678.00
IUUC-Tni-120707 Tetraodon nigroviridis 81.09 0.00e+00 7432.00
IUUC-Tbe-127346 Tupaia belangeri 90.01 0.00e+00 2608.00
IUUC-Ttr-128542 Tursiops truncatus 93.72 0.00e+00 5969.00
IUUC-Vpa-130611 Vicugna pacos 97.04 0.00e+00 4013.00
IUUC-Xtr-131933 Xenopus tropicalis 85.17 0.00e+00 7687.00
Created Date 25-Jun-2017

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