iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-08	36.4	231	272

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+   + ++ lpC+H+fh +C+  w        ++++CP+Cr
   Q: 231  CPVCKEDYalGESVRQLPCNHLFHDSCIVPW------LEQHDSCPVCR 272
           ********88555******************......**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (PubMed:23418353). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity). Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (By similarity). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (By similarity). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (By similarity). May monoubiquitinate AICDA (By similarity).

Protein Sequence
(Fasta)

MAEASPQPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRNTENG SAPSTAPTDQ 60
NRQPFENVDQ HLFTLPQGYS QFAFGIFDDS FEIPTFPPGA QADDGRDPES RREREHQSRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGCCGTG CGTGCCGTGC GTGCCATGCG TGAGCGTGCG CGGGCGCGTC GGCCGGCGAG 60
GGAGCAGCAA ACGGCCGGCG GCAGGCGCCG CGCGGGGGGC GGGCGGCGCG GAGGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005154--F:epidermal growth factor receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042127--P:regulation of cell proliferation
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

mmu:70294

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000551	Aegilops tauschii	45.79	1.00e-24	106.00
IUUC-Aml-002001	Ailuropoda melanoleuca	92.65	5.00e-146	509.00
IUUC-Atr-002522	Amborella trichopoda	48.42	2.00e-26	112.00
IUUC-Apl-003778	Anas platyrhynchos	79.60	6.00e-100	356.00
IUUC-Aca-005166	Anolis carolinensis	78.49	6.00e-110	390.00
IUUC-Ath-007616	Arabidopsis thaliana	31.60	3.00e-29	122.00
IUUC-Acl-008247	Aspergillus clavatus	41.96	1.00e-18	87.80
IUUC-Afl-008423	Aspergillus flavus	42.42	1.00e-17	84.70
IUUC-Afu-008920	Aspergillus fumigatus	44.44	1.00e-17	84.30
IUUC-Ani-009396	Aspergillus nidulans	40.82	2.00e-16	80.50
IUUC-Ang-009638	Aspergillus niger	45.19	2.00e-17	83.60
IUUC-Aor-009896	Aspergillus oryzae	42.00	1.00e-17	84.30
IUUC-Ame-010626	Astyanax mexicanus	72.76	2.00e-117	415.00
IUUC-Bgr-012144	Blumeria graminis	34.62	6.00e-18	85.90
IUUC-Bta-012808	Bos taurus	92.10	6.00e-137	479.00
IUUC-Bdi-014137	Brachypodium distachyon	31.00	2.00e-26	112.00
IUUC-Cel-018216	Caenorhabditis elegans	40.79	2.00e-14	73.20
IUUC-Cja-019575	Callithrix jacchus	87.94	1.00e-132	465.00
IUUC-Cfa-020142	Canis familiaris	92.51	4.00e-129	454.00
IUUC-Cpo-022451	Cavia porcellus	92.58	3.00e-140	491.00
IUUC-Csa-023433	Chlorocebus sabaeus	92.31	3.00e-161	560.00
IUUC-Cgl-026759	Colletotrichum gloeosporioides	36.36	1.00e-16	81.30
IUUC-Cne-026837	Cryptococcus neoformans	39.76	2.00e-15	77.40
IUUC-Cme-027122	Cyanidioschyzon merolae	54.00	2.00e-13	70.90
IUUC-Dre-027400	Danio rerio	73.57	1.00e-118	419.00
IUUC-Dno-029349	Dasypus novemcinctus	91.57	2.00e-108	385.00
IUUC-Dor-030103	Dipodomys ordii	94.06	2.00e-122	431.00
IUUC-Eca-034240	Equus caballus	90.75	3.00e-103	367.00
IUUC-Fal-037027	Ficedula albicollis	81.85	1.00e-106	379.00
IUUC-Fox-037736	Fusarium oxysporum	37.08	1.00e-13	70.90
IUUC-Fso-038447	Fusarium solani	36.46	2.00e-15	77.80
IUUC-Gmo-039694	Gadus morhua	71.91	7.00e-126	443.00
IUUC-Gga-040682	Gallus gallus	84.25	1.00e-128	452.00
IUUC-Gac-041364	Gasterosteus aculeatus	69.42	3.00e-114	404.00
IUUC-Gma-043643	Glycine max	31.73	1.00e-26	113.00
IUUC-Ggo-045421	Gorilla gorilla	90.74	8.00e-134	469.00
IUUC-Hsa-046723	Homo sapiens	93.45	6.00e-151	526.00
IUUC-Hvu-047602	Hordeum vulgare	29.58	1.00e-24	107.00
IUUC-Itr-048435	Ictidomys tridecemlineatus	95.13	6.00e-128	449.00
IUUC-Lch-050071	Latimeria chalumnae	82.43	5.00e-130	456.00
IUUC-Lpe-051427	Leersia perrieri	48.62	2.00e-26	112.00
IUUC-Loc-052470	Lepisosteus oculatus	64.86	2.00e-95	342.00
IUUC-Lma-053066	Leptosphaeria maculans	43.00	9.00e-21	95.10
IUUC-Laf-054249	Loxodonta africana	70.77	2.00e-70	258.00
IUUC-Mcc-055739	Macaca mulatta	93.29	3.00e-153	534.00
IUUC-Mor-057098	Magnaporthe oryzae	34.72	3.00e-12	67.00
IUUC-Mpo-057470	Magnaporthe poae	32.54	3.00e-12	66.60
IUUC-Mtr-057697	Medicago truncatula	26.20	2.00e-24	105.00
IUUC-Mga-059349	Meleagris gallopavo	80.14	2.00e-115	409.00
IUUC-Mvi-060434	Microbotryum violaceum	37.12	3.00e-19	90.10
IUUC-Mmr-060653	Microcebus murinus	94.57	5.00e-157	546.00
IUUC-Mdo-062442	Monodelphis domestica	89.04	1.00e-148	518.00
IUUC-Mac-065133	Musa acuminata	30.26	2.00e-27	115.00
IUUC-Mpu-065917	Mustela putorius furo	89.40	7.00e-131	459.00
IUUC-Mlu-067495	Myotis lucifugus	93.15	9.00e-146	509.00
IUUC-Nfi-068352	Neosartorya fischeri	44.44	9.00e-18	84.70
IUUC-Nle-069274	Nomascus leucogenys	93.45	8.00e-142	496.00
IUUC-Opr-070359	Ochotona princeps	83.61	1.00e-91	329.00
IUUC-Ont-071505	Oreochromis niloticus	74.56	3.00e-121	427.00
IUUC-Oan-073225	Ornithorhynchus anatinus	82.26	1.00e-117	415.00
IUUC-Oba-075047	Oryza barthii	49.09	5.00e-27	114.00
IUUC-Obr-076829	Oryza brachyantha	50.91	9.00e-28	117.00
IUUC-Ogl-077378	Oryza glaberrima	49.09	6.00e-27	114.00
IUUC-Ogu-078709	Oryza glumaepatula	49.09	5.00e-27	114.00
IUUC-Oin-079595	Oryza indica	50.00	8.00e-22	99.40
IUUC-Olo-080762	Oryza longistaminata	49.09	5.00e-27	114.00
IUUC-Ome-081151	Oryza meridionalis	50.51	5.00e-24	105.00
IUUC-Oni-083090	Oryza nivara	49.09	5.00e-27	114.00
IUUC-Opu-083898	Oryza punctata	50.96	1.00e-26	113.00
IUUC-Oru-084267	Oryza rufipogon	49.09	5.00e-27	114.00
IUUC-Osa-086229	Oryza sativa	49.09	5.00e-27	114.00
IUUC-Ola-086315	Oryzias latipes	68.73	2.00e-116	411.00
IUUC-Oga-088067	Otolemur garnettii	94.48	4.00e-142	497.00
IUUC-Ptr-091404	Pan troglodytes	92.89	9.00e-112	395.00
IUUC-Pan-092424	Papio anubis	90.32	2.00e-151	528.00
IUUC-Psi-093171	Pelodiscus sinensis	84.01	3.00e-117	414.00
IUUC-Pma-094408	Petromyzon marinus	45.32	4.00e-63	234.00
IUUC-Ppa-095873	Physcomitrella patens	42.42	2.00e-25	110.00
IUUC-Pfo-097402	Poecilia formosa	69.62	4.00e-119	421.00
IUUC-Pab-097834	Pongo abelii	90.71	4.00e-108	383.00
IUUC-Pop-099462	Populus trichocarpa	29.96	1.00e-25	110.00
IUUC-Pca-100442	Procavia capensis	92.41	3.00e-101	361.00
IUUC-Ppe-101324	Prunus persica	48.62	2.00e-25	109.00
IUUC-Pva-103240	Pteropus vampyrus	92.01	3.00e-157	547.00
IUUC-Pgr-103273	Puccinia graminis	38.33	8.00e-18	84.70
IUUC-Ptt-103768	Puccinia triticina	39.81	7.00e-16	79.00
IUUC-Pte-104223	Pyrenophora teres	40.98	5.00e-21	96.30
IUUC-Pyt-104653	Pyrenophora triticirepentis	40.16	5.00e-21	95.90
IUUC-Rno-105203	Rattus norvegicus	98.97	1.00e-152	532.00
IUUC-Sha-107638	Sarcophilus harrisii	87.27	1.00e-133	469.00
IUUC-Ssl-108600	Sclerotinia sclerotiorum	31.75	2.00e-12	67.40
IUUC-Smo-109651	Selaginella moellendorffii	51.69	2.00e-23	99.80
IUUC-Sit-110648	Setaria italica	52.25	4.00e-29	121.00
IUUC-Sly-111407	Solanum lycopersicum	28.48	4.00e-26	112.00
IUUC-Stu-112467	Solanum tuberosum	30.82	3.00e-26	112.00
IUUC-Sbi-114297	Sorghum bicolor	50.45	5.00e-28	117.00
IUUC-Tgu-117502	Taeniopygia guttata	83.22	1.00e-123	435.00
IUUC-Tru-117681	Takifugu rubripes	69.62	2.00e-116	411.00
IUUC-Tni-120092	Tetraodon nigroviridis	66.90	1.00e-111	395.00
IUUC-Tca-121480	Theobroma cacao	47.12	1.00e-25	110.00
IUUC-Tre-122013	Trichoderma reesei	33.12	2.00e-16	80.90
IUUC-Tvi-122598	Trichoderma virens	31.65	2.00e-16	80.90
IUUC-Tae-124679	Triticum aestivum	45.79	1.00e-24	107.00
IUUC-Ttr-128843	Tursiops truncatus	92.76	5.00e-144	503.00
IUUC-Vda-129671	Verticillium dahliae	32.14	5.00e-15	76.60
IUUC-Vvi-131691	Vitis vinifera	31.32	4.00e-27	115.00
IUUC-Xtr-132815	Xenopus tropicalis	58.13	1.00e-96	345.00
IUUC-Xma-133481	Xiphophorus maculatus	69.30	9.00e-119	419.00
IUUC-Zma-135326	Zea mays	50.93	2.00e-26	112.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence