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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064097
UUCD1 version UUC-MuM-01022
Ensembl Protein ID ENSMUSP00000076160.5
UniProt Accession Q9R1A8; RFWD2_MOUSE
Genbank Protein ID AAD51094.2; AAH82804.1
Protein Name E3 ubiquitin-protein ligase RFWD2; Constitutive photomorphogenesis protein 1 homolog; RING finger and WD repeat domain protein 2; RING-type E3 ubiquitin transferase RFWD2
Genbank Nucleotide ID AF151110; BC082804
Gene Name Rfwd2; Cop1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040782.12 ENSMUST00000195800.5 ENSMUSP00000141941.1
ENSMUSG00000040782.12 ENSMUST00000076894.10 ENSMUSP00000076160.5
ENSMUSG00000040782.12 ENSMUST00000192215.5 ENSMUSP00000141285.1
ENSMUSG00000040782.12 ENSMUST00000195554.5 ENSMUSP00000141561.1
ENSMUSG00000040782.12 ENSMUST00000192762.5 ENSMUSP00000142031.1
ENSMUSG00000040782.12 ENSMUST00000192044.1 ENSMUSP00000141490.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.50e-06 28.2 138 176
E3 adaptor/Cullin RING/DCX/DWD 3.50e-23 81.8 472 501
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++++  + + CgH f+ +C+++          + rCP C+
   Q: 138  CPICFDMIEE-AYMTKCGHSFCYKCIHQS------LEDNNRCPKCN 176
           ********99.888***********9555......999999****6 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWD 29
           +++++c+++     +ll+s+ + gt+ +WD
   Q: 472  NSKISCISWssYHkNLLASSDYEGTVILWD 501
           689******9622599************** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif.
Protein Sequence
(Fasta)
MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AASAATLVSG GVAPAAGSGG 60
LGGPGRPVLV AAAVSGSASA GGAVSAGQSR LSCAARPSAG VGGSSSSLGS SSRKRPLLVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064097|E3,RING;E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGCCCGTC TCCCGGCGCG TCCTCAGGAT GCTCGGGAGC TGAGCGCCGG GGGCGGCGGA 60
GGGTCGCGGT CTGTCCGGGC CCTCGCCTCG GAGCGCAGGG CCAAGGGAGG GAGTCACGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064097|E3,RING;E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00400--WD40
SMART

SM00184--RING
SM00320--WD40
Gene Ontology

GO:0000139--C:Golgi membrane
GO:0016607--C:nuclear speck
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010212--P:response to ionizing radiation
KEGG mmu:26374
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000885 Aegilops tauschii 39.94 2.00e-126 446.00
IUUC-Aml-001265 Ailuropoda melanoleuca 99.35 0.00e+00 1247.00
IUUC-Atr-002460 Amborella trichopoda 38.52 9.00e-125 441.00
IUUC-Apl-003796 Anas platyrhynchos 97.93 0.00e+00 1156.00
IUUC-Aca-005078 Anolis carolinensis 97.58 0.00e+00 1214.00
IUUC-Aly-006014 Arabidopsis lyrata 40.03 2.00e-130 459.00
IUUC-Ath-007636 Arabidopsis thaliana 39.94 3.00e-130 459.00
IUUC-Ame-011176 Astyanax mexicanus 74.73 8.00e-70 258.00
IUUC-Bta-012595 Bos taurus 98.91 0.00e+00 1261.00
IUUC-Bdi-014152 Brachypodium distachyon 39.08 4.00e-129 455.00
IUUC-Bol-016380 Brassica oleracea 40.21 1.00e-131 464.00
IUUC-Bra-017690 Brassica rapa 39.24 2.00e-126 446.00
IUUC-Cja-018926 Callithrix jacchus 98.76 0.00e+00 1256.00
IUUC-Cfa-021088 Canis familiaris 98.61 0.00e+00 1263.00
IUUC-Cpo-022442 Cavia porcellus 97.78 0.00e+00 1222.00
IUUC-Cre-022579 Chlamydomonas reinhardtii 33.45 3.00e-33 135.00
IUUC-Csa-024119 Chlorocebus sabaeus 97.08 0.00e+00 1247.00
IUUC-Cho-024883 Choloepus hoffmanni 66.23 2.00e-105 376.00
IUUC-Cin-025375 Ciona intestinalis 55.96 0.00e+00 684.00
IUUC-Cme-027350 Cyanidioschyzon merolae 41.62 1.00e-79 291.00
IUUC-Dre-028453 Danio rerio 87.56 0.00e+00 1083.00
IUUC-Dno-029887 Dasypus novemcinctus 98.44 0.00e+00 1249.00
IUUC-Dor-031110 Dipodomys ordii 89.73 0.00e+00 875.00
IUUC-Ete-033016 Echinops telfairi 84.50 0.00e+00 1044.00
IUUC-Eca-034403 Equus caballus 98.96 0.00e+00 1159.00
IUUC-Eeu-034690 Erinaceus europaeus 82.02 0.00e+00 961.00
IUUC-Fca-036475 Felis catus 98.62 0.00e+00 1162.00
IUUC-Fal-037189 Ficedula albicollis 98.49 0.00e+00 1191.00
IUUC-Gmo-039245 Gadus morhua 86.79 0.00e+00 1058.00
IUUC-Gga-040806 Gallus gallus 98.39 0.00e+00 1240.00
IUUC-Gac-042177 Gasterosteus aculeatus 88.16 0.00e+00 1102.00
IUUC-Gma-044187 Glycine max 40.58 4.00e-127 448.00
IUUC-Ggo-044430 Gorilla gorilla 98.09 0.00e+00 932.00
IUUC-Hsa-045853 Homo sapiens 98.76 0.00e+00 1256.00
IUUC-Hvu-047750 Hordeum vulgare 38.97 4.00e-95 343.00
IUUC-Itr-048238 Ictidomys tridecemlineatus 100.00 6.00e-145 506.00
IUUC-Lch-050420 Latimeria chalumnae 92.52 0.00e+00 1156.00
IUUC-Lpe-051219 Leersia perrieri 38.82 2.00e-124 439.00
IUUC-Loc-052728 Lepisosteus oculatus 91.13 0.00e+00 1107.00
IUUC-Laf-053775 Loxodonta africana 97.97 0.00e+00 1256.00
IUUC-Meu-056595 Macropus eugenii 77.93 1.00e-177 616.00
IUUC-Mtr-058555 Medicago truncatula 40.80 8.00e-134 471.00
IUUC-Mga-059646 Meleagris gallopavo 97.60 0.00e+00 1154.00
IUUC-Mmr-060990 Microcebus murinus 98.75 0.00e+00 1256.00
IUUC-Mdo-062287 Monodelphis domestica 98.71 0.00e+00 1247.00
IUUC-Mac-065240 Musa acuminata 41.22 4.00e-136 478.00
IUUC-Mpu-066612 Mustela putorius furo 98.63 0.00e+00 1166.00
IUUC-Mlu-067967 Myotis lucifugus 96.82 0.00e+00 1165.00
IUUC-Nle-069543 Nomascus leucogenys 98.91 0.00e+00 1261.00
IUUC-Opr-070366 Ochotona princeps 84.11 0.00e+00 717.00
IUUC-Ont-071522 Oreochromis niloticus 87.84 0.00e+00 1091.00
IUUC-Oan-073409 Ornithorhynchus anatinus 98.45 0.00e+00 1160.00
IUUC-Ocu-073756 Oryctolagus cuniculus 98.88 0.00e+00 1229.00
IUUC-Oba-075149 Oryza barthii 39.75 5.00e-127 449.00
IUUC-Obr-076563 Oryza brachyantha 39.63 2.00e-127 449.00
IUUC-Ogl-077701 Oryza glaberrima 39.78 1.00e-127 450.00
IUUC-Ogu-078383 Oryza glumaepatula 39.78 1.00e-127 450.00
IUUC-Oin-079965 Oryza indica 37.56 7.00e-114 404.00
IUUC-Olo-080639 Oryza longistaminata 39.31 2.00e-125 442.00
IUUC-Ome-081821 Oryza meridionalis 38.70 2.00e-115 410.00
IUUC-Oni-082622 Oryza nivara 39.78 1.00e-127 450.00
IUUC-Opu-083295 Oryza punctata 39.48 2.00e-127 449.00
IUUC-Oru-084661 Oryza rufipogon 39.78 1.00e-127 450.00
IUUC-Osa-085766 Oryza sativa 39.78 1.00e-127 450.00
IUUC-Ola-086727 Oryzias latipes 87.66 0.00e+00 1108.00
IUUC-Olu-087702 Ostreococcus lucimarinus 42.99 3.00e-69 255.00
IUUC-Oga-088215 Otolemur garnettii 96.89 0.00e+00 1234.00
IUUC-Oar-089880 Ovis aries 98.88 0.00e+00 1229.00
IUUC-Ptr-090597 Pan troglodytes 98.76 0.00e+00 1256.00
IUUC-Pan-091987 Papio anubis 98.91 0.00e+00 1261.00
IUUC-Psi-094033 Pelodiscus sinensis 97.97 0.00e+00 1167.00
IUUC-Pma-094587 Petromyzon marinus 70.38 0.00e+00 803.00
IUUC-Ppa-095256 Physcomitrella patens 39.73 3.00e-133 469.00
IUUC-Pfo-097388 Poecilia formosa 87.00 0.00e+00 1072.00
IUUC-Pab-098029 Pongo abelii 98.76 0.00e+00 1258.00
IUUC-Pop-099319 Populus trichocarpa 38.92 4.00e-131 462.00
IUUC-Pca-100846 Procavia capensis 90.48 0.00e+00 1143.00
IUUC-Ppe-101250 Prunus persica 38.89 7.00e-121 427.00
IUUC-Pva-102407 Pteropus vampyrus 98.45 0.00e+00 1249.00
IUUC-Rno-105312 Rattus norvegicus 99.53 0.00e+00 1266.00
IUUC-Sha-106514 Sarcophilus harrisii 98.66 0.00e+00 768.00
IUUC-Smo-109418 Selaginella moellendorffii 39.94 9.00e-131 460.00
IUUC-Sit-110248 Setaria italica 38.77 3.00e-128 452.00
IUUC-Sly-110964 Solanum lycopersicum 40.64 4.00e-132 465.00
IUUC-Stu-112882 Solanum tuberosum 40.89 2.00e-133 469.00
IUUC-Sar-113230 Sorex araneus 71.86 0.00e+00 799.00
IUUC-Sbi-113962 Sorghum bicolor 37.19 7.00e-124 437.00
IUUC-Ssc-115987 Sus scrofa 98.52 0.00e+00 627.00
IUUC-Tgu-116471 Taeniopygia guttata 98.06 0.00e+00 1233.00
IUUC-Tru-118231 Takifugu rubripes 87.84 0.00e+00 1057.00
IUUC-Tsy-119415 Tarsius syrichta 98.66 0.00e+00 1173.00
IUUC-Tni-120893 Tetraodon nigroviridis 88.01 0.00e+00 1065.00
IUUC-Tca-121703 Theobroma cacao 41.05 9.00e-130 457.00
IUUC-Tae-125317 Triticum aestivum 40.92 2.00e-134 473.00
IUUC-Tur-126557 Triticum urartu 40.62 1.00e-129 456.00
IUUC-Tbe-127253 Tupaia belangeri 71.32 0.00e+00 848.00
IUUC-Ttr-129100 Tursiops truncatus 97.48 0.00e+00 1145.00
IUUC-Vpa-130613 Vicugna pacos 92.61 0.00e+00 1097.00
IUUC-Vvi-130880 Vitis vinifera 40.90 2.00e-123 436.00
IUUC-Xtr-132033 Xenopus tropicalis 95.33 0.00e+00 1236.00
IUUC-Xma-133421 Xiphophorus maculatus 86.84 0.00e+00 1071.00
Created Date 25-Jun-2017

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