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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046204
UUCD1 version UUC-HoS-01163
Ensembl Protein ID ENSP00000285679.6
UniProt Accession Q9UHP3; C0LSZ0; Q6DHZ9; Q9H9W1; UBP25_HUMAN
Genbank Protein ID AAF32263.1; AAF24998.1; ACN76567.1; EAX10041.1; AAH75792.1; BAB14107.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; USP on chromosome 21; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25
Genbank Nucleotide ID AF170562; AF134213; FJ763652; CH471079; BC075792; AK022574
Gene Name USP25; USP21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000155313.15 ENST00000285679.10 ENSP00000285679.6
ENSG00000155313.15 ENST00000351097.9 ENSP00000299574.6
ENSG00000155313.15 ENST00000285681.6 ENSP00000285681.2
ENSG00000155313.15 ENST00000453553.1 ENSP00000404086.1
ENSG00000155313.15 ENST00000449491.1 ENSP00000402354.1
ENSG00000155313.15 ENST00000400183.6 ENSP00000383044.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 23754700
UBD/Alpha-Helix/UIM UIM 23754700
DUB/USP USP 18538659; 19615732
Classification
Family E-value Score Start End
DUB/USP 1.00e-62 214.0 169 655
UBD/Alpha-Helix/DUIM 0.018 16.7 97 115
UBD/Alpha-Helix/UBA 0.00018 23.2 19 54
Active Site
Position(s) Description Evidence
178 N/A {ECO:0000269|PubMed:19440361}
599 {ECO:0000250}
607 {ECO:0000250}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ + ++
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-NDSQ 259
           6******************************99988889999999999999*******************************99997.9*** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
           qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l+v+g +
   Q: 260  QQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPLQVNGFK 331
           *******************33..................123456788999************777664..444556899************ PP
   S: 181  etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts..... 267
                +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++++++     
   Q: 332  -----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRnreit 412
           .....9**************96...999998865...589***********************************************88888 PP
   S: 268  .........................................................................................pee 270
                                                                                                    p  
   Q: 413  rikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstteqqgalsselP-- 502
           888888888888888888888888888888888888888877777777777777777777777777777777777665555555555550.. PP
   S: 271  kqke....................................................................................kkkY 278
              +                                                                                    ++ Y
   Q: 503  ---StspssvaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrtielmysdksmiQVPY 591
           ...0555555556666666666666666666666666666666666667777777777777777777788888888888888888888**** PP
   S: 279  eLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
           +L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 592  RLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 655
           **********************966556***************99997779************6 PP
   

   UBD/Alpha-Helix/DUIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           d+ ++Lq+A+alSl E ++
   Q: 97   DDKDDLQRAIALSLAESNR 115
           6889************875 PP
   

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlve.MGF.dreealqaLraannnleaAveyL 38
             l+ql+e +G+ d++  +qaL ++n+nle Av++L
   Q: 19   TFLNQLREiTGInDTQILQQALKDSNGNLELAVAFL 54
           569*******************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Homodimer or oligomer. Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels.
 Homodimer or oligomer. Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels.
Protein Sequence
(Fasta)
MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046204|UBD,UBA;UBD,UIM;DUB,USP;UBD,DUIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGCAGCCCG CGGACCGGCA GCAAAGGAAC GTGCGAACGC GTGACGCCGC CCGACTGGCT 60
CGCGCTCTCC CGTGCCCCGG CGTCCTCCGC CCGCTCATGG CCCGGGCCGC CGCGGACGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046204|UBD,UBA;UBD,UIM;DUB,USP;UBD,DUIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
PF02809--UIM
SMART

SM00726--UIM
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0051117--F:ATPase binding
GO:0008233--F:peptidase activity
GO:0032183--F:SUMO binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1904455--F:ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
GO:0006464--P:cellular protein modification process
GO:1904293--P:negative regulation of ERAD pathway
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006508--P:proteolysis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:29761
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001340 Ailuropoda melanoleuca 94.01 0.00e+00 1976.00
IUUC-Apl-004030 Anas platyrhynchos 83.35 0.00e+00 1815.00
IUUC-Aca-004753 Anolis carolinensis 64.86 0.00e+00 992.00
IUUC-Ani-009503 Aspergillus nidulans 33.02 9.00e-11 63.20
IUUC-Ame-010624 Astyanax mexicanus 70.69 0.00e+00 1076.00
IUUC-Bta-013166 Bos taurus 96.39 0.00e+00 1969.00
IUUC-Cel-018346 Caenorhabditis elegans 28.61 2.00e-29 125.00
IUUC-Cja-019150 Callithrix jacchus 99.36 0.00e+00 1467.00
IUUC-Cfa-020649 Canis familiaris 96.79 0.00e+00 1454.00
IUUC-Cpo-021807 Cavia porcellus 93.65 0.00e+00 2056.00
IUUC-Csa-023388 Chlorocebus sabaeus 99.35 0.00e+00 1469.00
IUUC-Cho-024343 Choloepus hoffmanni 83.60 0.00e+00 970.00
IUUC-Cin-025302 Ciona intestinalis 37.50 3.00e-96 345.00
IUUC-Cgl-026575 Colletotrichum gloeosporioides 53.19 6.00e-10 60.50
IUUC-Dre-028016 Danio rerio 77.01 0.00e+00 1190.00
IUUC-Dno-029495 Dasypus novemcinctus 93.56 0.00e+00 1439.00
IUUC-Dor-030948 Dipodomys ordii 82.04 0.00e+00 1427.00
IUUC-Fca-035876 Felis catus 96.92 0.00e+00 1994.00
IUUC-Fal-036762 Ficedula albicollis 84.41 0.00e+00 1115.00
IUUC-Gmo-039490 Gadus morhua 72.52 0.00e+00 1528.00
IUUC-Gga-040817 Gallus gallus 85.22 0.00e+00 1348.00
IUUC-Gac-042473 Gasterosteus aculeatus 72.39 0.00e+00 1565.00
IUUC-Ggo-044939 Gorilla gorilla 95.12 0.00e+00 1959.00
IUUC-Kpa-049349 Komagataella pastoris 28.12 3.00e-10 61.60
IUUC-Lch-049572 Latimeria chalumnae 79.27 0.00e+00 1218.00
IUUC-Loc-052070 Lepisosteus oculatus 76.18 0.00e+00 1222.00
IUUC-Lma-053078 Leptosphaeria maculans 30.56 5.00e-12 67.40
IUUC-Laf-054426 Loxodonta africana 96.90 0.00e+00 1831.00
IUUC-Mcc-055858 Macaca mulatta 99.49 0.00e+00 1499.00
IUUC-Mga-059808 Meleagris gallopavo 85.61 0.00e+00 1827.00
IUUC-Mmr-060987 Microcebus murinus 98.07 0.00e+00 1450.00
IUUC-Mmu-064245 Mus musculus 93.66 0.00e+00 1984.00
IUUC-Mpu-066304 Mustela putorius furo 96.35 0.00e+00 1428.00
IUUC-Mlu-067139 Myotis lucifugus 96.06 0.00e+00 2001.00
IUUC-Nle-069075 Nomascus leucogenys 99.62 0.00e+00 2022.00
IUUC-Ont-072150 Oreochromis niloticus 76.14 0.00e+00 1200.00
IUUC-Oan-073054 Ornithorhynchus anatinus 80.20 0.00e+00 1690.00
IUUC-Ocu-074102 Oryctolagus cuniculus 94.30 0.00e+00 1446.00
IUUC-Ola-086529 Oryzias latipes 69.93 0.00e+00 1503.00
IUUC-Oga-088939 Otolemur garnettii 95.94 0.00e+00 1993.00
IUUC-Oar-090266 Ovis aries 97.25 0.00e+00 1430.00
IUUC-Ptr-090546 Pan troglodytes 99.62 0.00e+00 2023.00
IUUC-Pan-092311 Papio anubis 99.36 0.00e+00 1498.00
IUUC-Psi-093459 Pelodiscus sinensis 91.03 0.00e+00 1175.00
IUUC-Pfo-096726 Poecilia formosa 74.91 0.00e+00 1182.00
IUUC-Pab-097608 Pongo abelii 96.64 0.00e+00 1979.00
IUUC-Pca-100718 Procavia capensis 91.90 0.00e+00 1236.00
IUUC-Pva-103150 Pteropus vampyrus 92.60 0.00e+00 1463.00
IUUC-Rno-105727 Rattus norvegicus 94.22 0.00e+00 1953.00
IUUC-Sha-107051 Sarcophilus harrisii 89.71 0.00e+00 1858.00
IUUC-Ssl-108532 Sclerotinia sclerotiorum 28.85 8.00e-09 56.60
IUUC-Sar-113097 Sorex araneus 86.66 0.00e+00 1819.00
IUUC-Ssc-115877 Sus scrofa 94.26 0.00e+00 1961.00
IUUC-Tgu-117473 Taeniopygia guttata 78.23 0.00e+00 1682.00
IUUC-Tru-118135 Takifugu rubripes 67.46 0.00e+00 1419.00
IUUC-Tsy-119471 Tarsius syrichta 89.99 0.00e+00 1792.00
IUUC-Tni-120139 Tetraodon nigroviridis 67.71 0.00e+00 1340.00
IUUC-Tbe-127549 Tupaia belangeri 90.58 0.00e+00 1868.00
IUUC-Ttr-128896 Tursiops truncatus 90.06 0.00e+00 1890.00
IUUC-Vpa-130500 Vicugna pacos 93.58 0.00e+00 1333.00
IUUC-Xtr-132896 Xenopus tropicalis 81.17 0.00e+00 1727.00
IUUC-Xma-133349 Xiphophorus maculatus 74.72 0.00e+00 1605.00
Created Date 25-Jun-2017

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