PTM - dbPAF Gene Name UniProt ID Position Type Species RFFL; RNF189; RNF34L Q8WZ73 149 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 150 T Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 152 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 211 Y Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 224 T Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 226 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 229 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 232 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 240 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 242 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 245 T Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 29 Y Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 30 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 34 Y Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 36 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 39 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 46 S Homo sapiens(Human) RFFL; RNF189; RNF34L Q8WZ73 57 T Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type RFFL; RNF189; RNF34L rs1058574 CCT->CTT P->L 34 Y QAYSNPGYSSFPSPT 34 Phosphorylation TypeIII- RFFL; RNF189; RNF34L rs34747500 CGT->CAT R->H 150 T EDRTRASTLSPDFPE 150 Phosphorylation TypeIII- RFFL; RNF189; RNF34L rs1058574 CCT->CTT P->L 34 Y QAYSNPGYSSFPSPT 34 Phosphorylation TypeIII- RFFL; RNF189; RNF34L rs34747500 CGT->CAT R->H 150 T EDRTRASTLSPDFPE 150 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8WZ73 K105-ac Acetylation REELMKMkVKDLRDY Q8WZ73 Y29-p Phosphorylation QGARMQAysNPGySs Q8WZ73 S30-p Phosphorylation GARMQAysNPGySsF Q8WZ73 Y34-p Phosphorylation QAysNPGySsFPsPT Q8WZ73 S36-p Phosphorylation ysNPGySsFPsPTGL Q8WZ73 S39-p Phosphorylation PGySsFPsPTGLEPS Q8WZ73 T57-p Phosphorylation CGAHFANtARKQTCL Q8WZ73 S149-p Phosphorylation QEDRTRAstLsPDFP Q8WZ73 T150-p Phosphorylation EDRTRAstLsPDFPE Q8WZ73 S152-p Phosphorylation RTRAstLsPDFPEQQ Q8WZ73 Y211-p Phosphorylation QDQEEPVyLESVARV Q8WZ73 T224-p Phosphorylation RVPAEDEtQsIDsED Q8WZ73 S226-p Phosphorylation PAEDEtQsIDsEDsF Q8WZ73 S229-p Phosphorylation DEtQsIDsEDsFVPG Q8WZ73 S232-p Phosphorylation QsIDsEDsFVPGRRA Q8WZ73 S240-p Phosphorylation FVPGRRAsLsDLtDL Q8WZ73 S242-p Phosphorylation PGRRAsLsDLtDLED Q8WZ73 T245-p Phosphorylation RAsLsDLtDLEDIEG Q8WZ73 K126-ub Ubiquitination STEMCREkEELVLLV

PTM - dbPTM UniProt ID Position Code Type Resources References Q8WZ73 34 Y Phosphorylation Swiss-Prot 1010711 18083107 Q8WZ73 226 S Phosphorylation Swiss-Prot 1010711 19690332 Q8WZ73 229 S Phosphorylation Swiss-Prot 1010711 15302935;19690332 Q8WZ73 240 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q8WZ73 242 S Phosphorylation Swiss-Prot 1010711 19690332 Q8WZ73 229 S Phosphorylation PhosphoELM.10011 15302935 Q8WZ73 240 S Phosphorylation PhosphoELM.10011 18669648 Q8WZ73 245 T Phosphorylation PhosphoELM.10011 18669648 Q8WZ73 34 Y Phosphorylation PhosphoELM.10011 18083107 Q8WZ73 149 S Phosphorylation Phosphositeplus.1010730 20736484 Q8WZ73 226 S Phosphorylation Phosphositeplus.1010730 19690332;20166139;20393185;22115753 Q8WZ73 229 S Phosphorylation Phosphositeplus.1010730 15302935;19415658;19690332;20166139;20363803;20393185;22115753 Q8WZ73 240 S Phosphorylation Phosphositeplus.1010730 18578522;18669648;19690332;20058876;20166139;20815410;21659604;22115753 Q8WZ73 242 S Phosphorylation Phosphositeplus.1010730 18578522;19690332;20058876;20166139;20815410 Q8WZ73 150 T Phosphorylation Phosphositeplus.1010730 20736484 Q8WZ73 245 T Phosphorylation Phosphositeplus.1010730 18578522;20166139 Q8WZ73 211 Y Phosphorylation Phosphositeplus.1010730 20736484 Q8WZ73 29 Y Phosphorylation Phosphositeplus.1010730 18083107 Q8WZ73 34 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19901323;20007894;20090780;20736484;21253578 Q8WZ73 226 S Phosphorylation HPRD 9.0 19651622,20166139 Q8WZ73 229 S Phosphorylation HPRD 9.0 15302935,19415658,19651622,20166139 Q8WZ73 240 S Phosphorylation HPRD 9.0 18669648,19651622,18452278,18578522,20166139,20068231,20058876 Q8WZ73 242 S Phosphorylation HPRD 9.0 17081983,18578522,20166139,20058876 Q8WZ73 245 T Phosphorylation HPRD 9.0 18669648,19651622,18578522,20166139 Q8WZ73 34 Y Phosphorylation HPRD 9.0 18083107,19901323 Q8WZ73 240 S Phosphorylation SysPTM 1.1 18669648 Q8WZ73 242 S Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References RFFL 226 S Phosphorylation 19651622,20166139 RFFL 229 S Phosphorylation 15302935,19415658,19651622,20166139 RFFL 240 S Phosphorylation 18669648,19651622,18452278,18578522,20166139,20068231,20058876 RFFL 242 S Phosphorylation 17081983,18578522,20166139,20058876 RFFL 245 T Phosphorylation 18669648,19651622,18578522,20166139 RFFL 34 Y Phosphorylation 18083107,19901323

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8WZ73 245 T 18669648 HTP Phosphorylation Q8WZ73 229 S 15302935 HTP Phosphorylation Q8WZ73 34 Y 18083107 HTP Phosphorylation Q8WZ73 240 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8WZ73 226 Phosphoserine 19690332 Q8WZ73 229 Phosphoserine 19690332;24275569

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 117584 125593 - K Ubiquitination 21963094 117584 125593 - K Ubiquitination 25147182