iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089838

Ensembl Protein ID

ENSOARP00000008513.1

UniProt Accession

W5PDK0; W5PDK0_SHEEP

Genbank Protein ID

ENSOARP00000008513

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01017585

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000007928.1	ENSOART00000008637.1	ENSOARP00000008513.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.50	1.00e-177	620.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ovis aries

Protein Sequence
(Fasta)

PSSPCLWRQI SDLIMWAACC NWFCLDGQPE EAPPPQGART QAYSNPGYSS FPSPTGSEPS 60
CKACGAHFAS MARKQTCLDC KKNFCTNCSS QVGAGPRLCL LCQRFRATAF RREELMKMKV 120

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Nucleotide Sequence
(Fasta)

GGGAAAAACT GCCTGTGTAA TCAAGGAAGA GTGCACTATG CTCCTCCCCG TCTACCCCAG 60
GGAAGAATAA CTGTTAGCTC CGATAGAGGG CTTCACCCAC AACTGTCACT TTGCTCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	85.83	1.00e-180	625.00
IUUC-Apl-004124	Anas platyrhynchos	63.56	1.00e-119	422.00
IUUC-Aly-005548	Arabidopsis lyrata	36.84	2.00e-08	54.30
IUUC-Ame-011616	Astyanax mexicanus	59.00	3.00e-105	375.00
IUUC-Bta-012374	Bos taurus	96.49	0.00e+00	704.00
IUUC-Cja-019780	Callithrix jacchus	86.54	0.00e+00	627.00
IUUC-Cfa-021252	Canis familiaris	89.07	6.00e-180	623.00
IUUC-Cpo-022047	Cavia porcellus	85.33	0.00e+00	626.00
IUUC-Csa-023161	Chlorocebus sabaeus	88.15	0.00e+00	664.00
IUUC-Cho-024316	Choloepus hoffmanni	85.48	1.00e-146	511.00
IUUC-Dre-028596	Danio rerio	56.02	2.00e-110	391.00
IUUC-Dno-029333	Dasypus novemcinctus	88.71	0.00e+00	640.00
IUUC-Ete-033163	Echinops telfairi	83.99	1.00e-161	562.00
IUUC-Eca-033994	Equus caballus	89.34	0.00e+00	650.00
IUUC-Eeu-035162	Erinaceus europaeus	81.00	2.00e-121	428.00
IUUC-Fca-036418	Felis catus	88.80	0.00e+00	668.00
IUUC-Fal-037427	Ficedula albicollis	66.48	4.00e-129	454.00
IUUC-Gga-041053	Gallus gallus	67.04	1.00e-127	449.00
IUUC-Ggo-045436	Gorilla gorilla	87.88	0.00e+00	661.00
IUUC-Hsa-045798	Homo sapiens	87.88	0.00e+00	661.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	80.73	6.00e-177	613.00
IUUC-Lch-050639	Latimeria chalumnae	61.16	2.00e-122	431.00
IUUC-Laf-053355	Loxodonta africana	80.22	6.00e-169	586.00
IUUC-Mcc-055222	Macaca mulatta	87.05	0.00e+00	629.00
IUUC-Meu-056692	Macropus eugenii	74.38	5.00e-152	530.00
IUUC-Mga-059298	Meleagris gallopavo	66.39	7.00e-127	446.00
IUUC-Mmr-061792	Microcebus murinus	86.74	2.00e-179	621.00
IUUC-Mdo-062986	Monodelphis domestica	76.99	2.00e-162	565.00
IUUC-Mmu-063356	Mus musculus	85.56	3.00e-178	617.00
IUUC-Mpu-066273	Mustela putorius furo	88.80	0.00e+00	669.00
IUUC-Mlu-066953	Myotis lucifugus	88.52	0.00e+00	656.00
IUUC-Nle-070075	Nomascus leucogenys	86.89	0.00e+00	662.00
IUUC-Opr-070838	Ochotona princeps	85.67	2.00e-179	620.00
IUUC-Ont-071967	Oreochromis niloticus	73.43	8.00e-55	207.00
IUUC-Ocu-074807	Oryctolagus cuniculus	86.89	0.00e+00	650.00
IUUC-Obr-076159	Oryza brachyantha	39.29	1.00e-07	48.90
IUUC-Ola-086903	Oryzias latipes	49.60	2.00e-91	328.00
IUUC-Oga-088536	Otolemur garnettii	85.64	8.00e-172	595.00
IUUC-Ptr-090962	Pan troglodytes	87.60	0.00e+00	660.00
IUUC-Pan-092853	Papio anubis	87.33	0.00e+00	659.00
IUUC-Psi-093164	Pelodiscus sinensis	68.32	4.00e-123	434.00
IUUC-Pma-094104	Petromyzon marinus	43.85	2.00e-55	209.00
IUUC-Pno-094968	Phaeosphaeria nodorum	38.78	1.00e-08	56.60
IUUC-Ppa-095285	Physcomitrella patens	29.60	2.00e-02	33.10
IUUC-Pab-098304	Pongo abelii	87.70	0.00e+00	665.00
IUUC-Pca-100316	Procavia capensis	83.20	8.00e-171	592.00
IUUC-Ppe-101490	Prunus persica	36.59	2.00e-08	53.90
IUUC-Pva-102612	Pteropus vampyrus	73.83	1.00e-150	525.00
IUUC-Rno-105449	Rattus norvegicus	85.64	9.00e-177	612.00
IUUC-Sha-107578	Sarcophilus harrisii	75.20	1.00e-149	522.00
IUUC-Sar-113638	Sorex araneus	84.30	7.00e-171	592.00
IUUC-Ssc-116401	Sus scrofa	89.76	0.00e+00	684.00
IUUC-Tru-118765	Takifugu rubripes	49.86	2.00e-82	298.00
IUUC-Tsy-118850	Tarsius syrichta	84.16	3.00e-144	504.00
IUUC-Tbe-128086	Tupaia belangeri	79.06	1.00e-167	582.00
IUUC-Ttr-128249	Tursiops truncatus	74.72	1.00e-143	502.00
IUUC-Vpa-130816	Vicugna pacos	89.53	2.00e-41	162.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence