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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046167
Ensembl Protein ID ENSP00000366748.3
UniProt Accession Q9Y679; C0H5W8; Q9H866; Q9UNQ6; Q9Y685; AUP1_HUMAN
Genbank Protein ID AAD43018.1; AAD43017.1; AAD43010.1; AAF86645.1; BAB14753.1; EAW99623.1; AAH01658.1; AAH33646.2
Protein Name Ancient ubiquitous protein 1
Genbank Nucleotide ID AF100754; AF100753; AF100746; AF165515; AK023983; CH471053; BC001658; BC033646
Gene Name AUP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000115307.16 ENST00000425118.5 ENSP00000403430.1
ENSG00000115307.16 ENST00000377526.3 ENSP00000366748.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/CUE CUE 24039768
Classification
Family E-value Score Start End
UBD/Alpha-Helix/CUE 3.50e-10 41.3 296 337
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+t+++++ke++P+++  viq++L a+tg+++ +++nLLeg+
   Q: 296  QLATLAQRVKEVLPHVPLGVIQRDL-AKTGCVDLTITNLLEGA 337
           689**********************.***************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
 May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Protein Sequence
(Fasta)
MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV 60
LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046167|UBD,CUE|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAGTAGGAC GCGGGGCACG CCGGTACCTG AAGTCCTTCA GAAGTGCACG CCGGGACCAG 60
GATTCCGGGA GGCCGACTCC TCCCTGCCCC ACGAATGCCG GGAATTGTGG TCTCCGCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046167|UBD,CUE|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
Interpro

IPR003892--CUE
PROSITE

PS51140--CUE
Pfam

PF02845--CUE
SMART

SM00546--CUE
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:550
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002330 Ailuropoda melanoleuca 96.84 3.00e-177 614.00
IUUC-Apl-003946 Anas platyrhynchos 56.25 2.00e-102 365.00
IUUC-Aca-004676 Anolis carolinensis 57.02 2.00e-27 114.00
IUUC-Acl-008157 Aspergillus clavatus 31.34 2.80e-01 28.90
IUUC-Bta-012397 Bos taurus 94.88 0.00e+00 722.00
IUUC-Bdi-014890 Brachypodium distachyon 31.73 1.00e-04 41.20
IUUC-Cel-018644 Caenorhabditis elegans 34.46 2.00e-43 170.00
IUUC-Cja-018775 Callithrix jacchus 80.68 0.00e+00 642.00
IUUC-Cfa-020710 Canis familiaris 96.63 0.00e+00 673.00
IUUC-Cpo-022111 Cavia porcellus 93.41 0.00e+00 697.00
IUUC-Csa-023411 Chlorocebus sabaeus 99.27 0.00e+00 745.00
IUUC-Cin-025458 Ciona intestinalis 38.32 4.00e-14 69.30
IUUC-Dre-027938 Danio rerio 53.62 2.00e-117 416.00
IUUC-Dno-028873 Dasypus novemcinctus 93.90 0.00e+00 705.00
IUUC-Dor-030537 Dipodomys ordii 81.49 4.00e-179 620.00
IUUC-Ete-032422 Echinops telfairi 64.49 1.00e-129 456.00
IUUC-Eca-033757 Equus caballus 94.39 0.00e+00 706.00
IUUC-Eeu-034556 Erinaceus europaeus 76.17 0.00e+00 630.00
IUUC-Fca-035438 Felis catus 95.12 0.00e+00 709.00
IUUC-Fal-036911 Ficedula albicollis 54.70 1.00e-95 343.00
IUUC-Gmo-039147 Gadus morhua 50.73 2.00e-103 369.00
IUUC-Gga-041239 Gallus gallus 57.51 2.00e-116 412.00
IUUC-Gac-041814 Gasterosteus aculeatus 52.30 3.00e-108 385.00
IUUC-Ggo-044745 Gorilla gorilla 99.33 6.00e-152 530.00
IUUC-Itr-048661 Ictidomys tridecemlineatus 96.08 0.00e+00 663.00
IUUC-Lch-050576 Latimeria chalumnae 53.00 1.00e-102 366.00
IUUC-Lpe-051312 Leersia perrieri 33.01 1.00e-03 38.10
IUUC-Loc-052028 Lepisosteus oculatus 53.79 1.00e-114 406.00
IUUC-Laf-053886 Loxodonta africana 92.52 0.00e+00 635.00
IUUC-Mcc-055399 Macaca mulatta 93.17 0.00e+00 671.00
IUUC-Meu-056355 Macropus eugenii 63.64 2.00e-122 432.00
IUUC-Mga-060065 Meleagris gallopavo 53.78 1.00e-94 340.00
IUUC-Mmu-064080 Mus musculus 91.45 5.00e-157 547.00
IUUC-Mpu-066233 Mustela putorius furo 96.77 0.00e+00 711.00
IUUC-Mlu-067489 Myotis lucifugus 94.88 0.00e+00 711.00
IUUC-Nle-070040 Nomascus leucogenys 99.00 5.00e-152 531.00
IUUC-Ont-071616 Oreochromis niloticus 51.98 1.00e-107 382.00
IUUC-Ocu-074618 Oryctolagus cuniculus 94.01 0.00e+00 696.00
IUUC-Obr-076127 Oryza brachyantha 34.95 8.00e-05 42.40
IUUC-Ogl-077799 Oryza glaberrima 34.29 5.00e-03 36.20
IUUC-Ola-086583 Oryzias latipes 43.97 1.00e-90 327.00
IUUC-Oga-089100 Otolemur garnettii 94.88 0.00e+00 716.00
IUUC-Oar-089813 Ovis aries 94.63 0.00e+00 719.00
IUUC-Ptr-091436 Pan troglodytes 99.76 0.00e+00 749.00
IUUC-Pan-092755 Papio anubis 99.02 0.00e+00 745.00
IUUC-Psi-093736 Pelodiscus sinensis 67.30 2.00e-55 208.00
IUUC-Pma-094429 Petromyzon marinus 49.60 5.00e-90 324.00
IUUC-Pfo-097015 Poecilia formosa 49.88 3.00e-102 365.00
IUUC-Pab-098382 Pongo abelii 99.51 0.00e+00 747.00
IUUC-Pca-100900 Procavia capensis 90.05 4.00e-87 315.00
IUUC-Pva-103248 Pteropus vampyrus 74.00 3.00e-163 568.00
IUUC-Rno-105755 Rattus norvegicus 91.82 4.00e-171 593.00
IUUC-Sha-107434 Sarcophilus harrisii 79.21 5.00e-106 377.00
IUUC-Stu-112774 Solanum tuberosum 28.04 6.00e-03 35.80
IUUC-Sar-113104 Sorex araneus 73.74 2.00e-100 358.00
IUUC-Ssc-116047 Sus scrofa 91.23 9.00e-172 595.00
IUUC-Tgu-117436 Taeniopygia guttata 56.92 8.00e-112 397.00
IUUC-Tru-118227 Takifugu rubripes 48.57 3.00e-102 365.00
IUUC-Tni-120873 Tetraodon nigroviridis 48.55 3.00e-103 369.00
IUUC-Ttr-128895 Tursiops truncatus 78.09 0.00e+00 633.00
IUUC-Xtr-131917 Xenopus tropicalis 55.56 3.00e-58 218.00
Created Date 25-Jun-2017

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