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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045834
UUCD1 version UUC-HoS-00424
Ensembl Protein ID ENSP00000366886.4
UniProt Accession Q9UJP4; B3KQP2; O75057; Q5SY26; Q5SY28; Q8N4I6; Q8NF10; KLH21_HUMAN
Genbank Protein ID BAA32314.2; BAG52104.1; CAI16080.1; CAI16082.1; EAW71559.1; AAH34039.3; AAH91648.1; BAC03453.1
Protein Name Kelch-like protein 21
Genbank Nucleotide ID AB007938; AK075305; AL591866; AL591866; CH471130; BC034039; BC091648; AK090472
Gene Name KLHL21; KIAA0469
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162413.16 ENST00000377658.8 ENSP00000366886.4
ENSG00000162413.16 ENST00000377663.3 ENSP00000366891.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 19995937
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.40e-19 69.8 36 100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.70e-09 35.0 136 164
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    Dvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           Dv+l+ + g+ f+ah++vLaa+S++F+a+f ++l+es+  ++v +++v p+ ++ ll+F+Ytg++ 
   Q: 36   DVTLEAAgGRDFPAHRAVLAAASPYFRAMFAGQLRESR-AERVRLHGVPPDMLQLLLDFSYTGRVA 100
           9*****99******************************.************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkh 30
            Ncl++ +fA++++c+ L++aa++fil+h
   Q: 136  ANCLDMQDFAEAFSCSGLASAAQRFILRH 164
           6***************************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Protein Sequence
(Fasta)
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH RAVLAAASPY 60
FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA VSGDNAEPLL RAADLLQFPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045834|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGGGCGGG GCGCGGGCCA CCGGGCCCGG GGGATCGGGG GAGCAGCCGG GGGCCTCGGG 60
AGCCGACCCC GGTCCGAGGG GGGCCTAAAA CTCCTCGAGA GCAACCGGAG CCAGGGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045834|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0035853--P:chromosome passenger complex localization to spindle midzone
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0032465--P:regulation of cytokinesis
KEGG hsa:9903
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001782 Ailuropoda melanoleuca 88.17 0.00e+00 911.00
IUUC-Apl-003189 Anas platyrhynchos 84.91 3.00e-141 494.00
IUUC-Ame-011774 Astyanax mexicanus 66.11 8.00e-137 479.00
IUUC-Bta-012367 Bos taurus 97.15 0.00e+00 1136.00
IUUC-Cja-019501 Callithrix jacchus 91.08 0.00e+00 1033.00
IUUC-Cfa-020550 Canis familiaris 97.15 0.00e+00 1137.00
IUUC-Cpo-022072 Cavia porcellus 97.42 0.00e+00 1112.00
IUUC-Csa-023364 Chlorocebus sabaeus 99.25 0.00e+00 1030.00
IUUC-Cin-025253 Ciona intestinalis 43.73 3.00e-148 518.00
IUUC-Csv-025871 Ciona savignyi 45.37 5.00e-154 538.00
IUUC-Dre-028694 Danio rerio 72.36 0.00e+00 858.00
IUUC-Dno-029082 Dasypus novemcinctus 93.96 0.00e+00 941.00
IUUC-Dor-030680 Dipodomys ordii 96.48 0.00e+00 1130.00
IUUC-Ete-032315 Echinops telfairi 96.33 0.00e+00 950.00
IUUC-Eca-033570 Equus caballus 96.73 0.00e+00 681.00
IUUC-Eeu-035067 Erinaceus europaeus 94.53 3.00e-141 495.00
IUUC-Fca-035663 Felis catus 91.91 3.00e-121 427.00
IUUC-Fal-037103 Ficedula albicollis 83.72 0.00e+00 898.00
IUUC-Gmo-039420 Gadus morhua 69.78 0.00e+00 841.00
IUUC-Ggr-039811 Gaeumannomyces graminis 38.36 5.00e-08 52.40
IUUC-Gga-040161 Gallus gallus 83.04 0.00e+00 862.00
IUUC-Gac-041755 Gasterosteus aculeatus 71.33 0.00e+00 861.00
IUUC-Ggo-044899 Gorilla gorilla 99.66 0.00e+00 1157.00
IUUC-Itr-048413 Ictidomys tridecemlineatus 96.82 0.00e+00 1133.00
IUUC-Lch-050338 Latimeria chalumnae 70.93 0.00e+00 872.00
IUUC-Loc-051780 Lepisosteus oculatus 74.52 0.00e+00 876.00
IUUC-Laf-053725 Loxodonta africana 94.25 0.00e+00 783.00
IUUC-Mcc-055032 Macaca mulatta 99.60 0.00e+00 987.00
IUUC-Meu-056661 Macropus eugenii 94.32 0.00e+00 768.00
IUUC-Mpo-057626 Magnaporthe poae 31.67 5.00e-07 49.30
IUUC-Mga-059821 Meleagris gallopavo 84.81 3.00e-125 440.00
IUUC-Mdo-062095 Monodelphis domestica 94.66 0.00e+00 958.00
IUUC-Mmu-063138 Mus musculus 96.65 0.00e+00 1138.00
IUUC-Mpu-066386 Mustela putorius furo 95.34 6.00e-180 623.00
IUUC-Mlu-067807 Myotis lucifugus 96.76 0.00e+00 688.00
IUUC-Nle-069181 Nomascus leucogenys 98.32 0.00e+00 1136.00
IUUC-Opr-070658 Ochotona princeps 96.82 0.00e+00 1157.00
IUUC-Ont-072209 Oreochromis niloticus 71.48 0.00e+00 850.00
IUUC-Oan-072861 Ornithorhynchus anatinus 90.23 5.00e-118 416.00
IUUC-Ocu-074631 Oryctolagus cuniculus 87.54 0.00e+00 984.00
IUUC-Ola-087553 Oryzias latipes 70.25 0.00e+00 837.00
IUUC-Oga-088782 Otolemur garnettii 96.82 0.00e+00 1140.00
IUUC-Oar-089634 Ovis aries 96.82 0.00e+00 1132.00
IUUC-Ptr-091259 Pan troglodytes 99.78 0.00e+00 862.00
IUUC-Pan-091734 Papio anubis 99.33 0.00e+00 1156.00
IUUC-Psi-092979 Pelodiscus sinensis 82.83 0.00e+00 920.00
IUUC-Pma-094459 Petromyzon marinus 52.86 3.00e-124 438.00
IUUC-Pfo-097446 Poecilia formosa 71.30 0.00e+00 848.00
IUUC-Pab-098765 Pongo abelii 99.33 0.00e+00 1155.00
IUUC-Pca-101018 Procavia capensis 99.42 4.00e-94 338.00
IUUC-Pva-102730 Pteropus vampyrus 94.14 0.00e+00 1091.00
IUUC-Rno-104972 Rattus norvegicus 97.42 0.00e+00 1134.00
IUUC-Ssc-115869 Sus scrofa 97.81 0.00e+00 979.00
IUUC-Tgu-116562 Taeniopygia guttata 83.57 0.00e+00 930.00
IUUC-Tru-118490 Takifugu rubripes 70.77 0.00e+00 843.00
IUUC-Tni-119898 Tetraodon nigroviridis 69.01 0.00e+00 810.00
IUUC-Ttr-128976 Tursiops truncatus 94.53 8.00e-141 494.00
IUUC-Xtr-132876 Xenopus tropicalis 74.39 0.00e+00 905.00
IUUC-Xma-133540 Xiphophorus maculatus 71.83 0.00e+00 852.00
Created Date 25-Jun-2017

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